Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Michael, Haertlein"'
Autor:
Lukas Gajdos, Matthew P. Blakeley, Michael Haertlein, V. Trevor Forsyth, Juliette M. Devos, Anne Imberty
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Pseudomonas aeruginosa employs lectins to bind to its host cells, and is known to be the major cause of lung infections. Lectin B (LecB) from Pseudomonas aeruginosa binds specifically to galactose and fucose and is important for pathogenicity, adhesi
Externí odkaz:
https://doaj.org/article/29c58929de124566b81fc6c4f5644b06
Autor:
Luke A. Perera, Steffen Preissler, Nathan R. Zaccai, Sylvain Prévost, Juliette M. Devos, Michael Haertlein, David Ron
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The ER chaperone BiP is regulated by FICD-mediated AMPylation and deAMPylation. Here, the authors characterise the structure of mammalian AMPylated BiP bound to FICD, by X-ray crystallography and neutron scattering, providing insights into the mechan
Externí odkaz:
https://doaj.org/article/b1546d211ae74008933f9a4fd1200d65
Autor:
Khushboo Borah, Tom A Mendum, Nathaniel D Hawkins, Jane L Ward, Michael H Beale, Gerald Larrouy‐Maumus, Apoorva Bhatt, Martine Moulin, Michael Haertlein, Gernot Strohmeier, Harald Pichler, V Trevor Forsyth, Stephan Noack, Celia W Goulding, Johnjoe McFadden, Dany J V Beste
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 5, Pp 1-16 (2021)
Abstract The co‐catabolism of multiple host‐derived carbon substrates is required by Mycobacterium tuberculosis (Mtb) to successfully sustain a tuberculosis infection. However, the metabolic plasticity of this pathogen and the complexity of the m
Externí odkaz:
https://doaj.org/article/1069c34eaaa04423b4e6683142460c70
Autor:
Joao Ramos, Valerie Laux, Michael Haertlein, Elisabetta Boeri Erba, Katherine E. McAuley, V. Trevor Forsyth, Estelle Mossou, Sine Larsen, Annette E. Langkilde
Publikováno v:
IUCrJ, Vol 8, Iss 3, Pp 372-386 (2021)
This structural and biophysical study exploited a method of perdeuterating hen egg-white lysozyme based on the expression of insoluble protein in Escherichia coli followed by in-column chemical refolding. This allowed detailed comparisons with perdeu
Externí odkaz:
https://doaj.org/article/3565e0046ecf4d2c85988c7aeffa2ba0
Autor:
Delaram Ahmadi, Katherine C. Thompson, Victoria García Sakai, Ralf Schweins, Martine Moulin, Michael Haertlein, Gernot A. Strohmeier, Harald Pichler, V. Trevor Forsyth, David J. Barlow, M. Jayne Lawrence, Fabrizia Foglia
Publikováno v:
Frontiers in Physics, Vol 10 (2022)
Quasi-elastic neutron scattering (QENS) and small angle neutron scattering (SANS), in combination with isotopic contrast variation, have been used to determine the structure and dynamics of three-component lipid membranes, in the form of vesicles, co
Externí odkaz:
https://doaj.org/article/fee38fd2cb2544db8225233244a8fdf8
Autor:
Marija Dubackic, Ilaria Idini, Veronica Lattanzi, Yun Liu, Anne Martel, Ann Terry, Michael Haertlein, Juliette M. Devos, Andrew Jackson, Emma Sparr, Sara Linse, Ulf Olsson
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
The dense accumulation of α-Synuclein fibrils in neurons is considered to be strongly associated with Parkinson’s disease. These intracellular inclusions, called Lewy bodies, also contain significant amounts of lipids. To better understand such ac
Externí odkaz:
https://doaj.org/article/a70ac20dcd964258a94530f9bd60ccae
Autor:
Yubexi Correa, Rita Del Giudice, Sarah Waldie, Michel Thépaut, Samantha Micciula, Yuri Gerelli, Martine Moulin, Clara Delaunay, Franck Fieschi, Harald Pichler, Michael Haertlein, V. Trevor Forsyth, Anton Le Brun, Michael Moir, Robert A. Russell, Tamim Darwish, Jonas Brinck, Tigist Wodaje, Martin Jansen, César Martín, Felix Roosen - Runge, Marité Cárdenas
Publikováno v:
Journal of Colloid and Interface Science. 645:627-638
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2aea781bf564f1a4d54c24d23529173
https://doi.org/10.1016/j.jcis.2023.04.137
https://doi.org/10.1016/j.jcis.2023.04.137
Autor:
Ai Woon Yee, Matteo Aldeghi, Matthew P. Blakeley, Andreas Ostermann, Philippe J. Mas, Martine Moulin, Daniele de Sanctis, Matthew W. Bowler, Christoph Mueller-Dieckmann, Edward P. Mitchell, Michael Haertlein, Bert L. de Groot, Elisabetta Boeri Erba, V. Trevor Forsyth
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
A number of disease-causing human transthyretin (TTR) mutations are known to lead to amyloid formation. Here the authors combine neutron crystallography, native mass spectrometry and modelling studies to characterize the T119M and S52P-TTR mutants, p
Externí odkaz:
https://doaj.org/article/d3204d9671444e838d043f4321cfd3bb
Autor:
Sarah Waldie, Federica Sebastiani, Martine Moulin, Rita Del Giudice, Nicolò Paracini, Felix Roosen-Runge, Yuri Gerelli, Sylvain Prevost, John C. Voss, Tamim A. Darwish, Nageshwar Yepuri, Harald Pichler, Selma Maric, V. Trevor Forsyth, Michael Haertlein, Marité Cárdenas
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Apolipoprotein E (ApoE), an important mediator of lipid transportation in plasma and the nervous system, plays a large role in diseases such as atherosclerosis and Alzheimer's. The major allele variants ApoE3 and ApoE4 differ only by one amino acid.
Externí odkaz:
https://doaj.org/article/9633a3e54bf542e08dd5a894dd1ccae2
Autor:
Alessandra Luchini, Giacomo Corucci, Krishna Chaithanya Batchu, Valerie Laux, Michael Haertlein, Viviana Cristiglio, Giovanna Fragneto
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Eukaryotic and prokaryotic cell membranes are difficult to characterize directly with biophysical methods. Membrane model systems, that include fewer molecular species, are therefore often used to reproduce their fundamental chemical and physical pro
Externí odkaz:
https://doaj.org/article/25a67be5beea4d65a9616c5fc278d5af