Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Michael, Gleimer"'
Autor:
Lisbeth A. Guethlein, Frances M. Brodsky, Amir Horowitz, Peter Parham, Ana Goyos, Michael Gleimer, Hugo G. Hilton
Publikováno v:
The Journal of Immunology. 195:3725-3736
Chimpanzees have orthologs of the six fixed, functional human MHC class I genes. But, in addition, the chimpanzee has a seventh functional gene, Patr-AL, which is not polymorphic but contributes substantially to population diversity by its presence o
Autor:
K. Christopher Garcia, John A. Hammond, William H. Hildebrand, Peter Parham, Monia Draghi, Baback Gharizadeh, Laurent Abi-Rached, Roxana Jalili, Erin J. Adams, Lisbeth A. Guethlein, Angela Wahl, Mostafa Ronaghi, Heather D. Hickman, Michael Gleimer, Paul Norman, Sean Juo
Publikováno v:
The Journal of Immunology. 186:1575-1588
Patr-AL is an expressed, non-polymorphic MHC class I gene carried by ∼50% of chimpanzee MHC haplotypes. Comparing Patr-AL+ and Patr-AL− haplotypes showed Patr-AL defines a unique 125-kb genomic block flanked by blocks containing classical Patr-A
Publikováno v:
Immunological Reviews. 238:169-181
Both αβ and γδ T cells develop in the thymus from a common progenitor. Historically distinguished by their T-cell receptor (TCR), these lineages are now defined on the basis of distinct molecular programs. Intriguingly, in many transgenic and kno
Publikováno v:
Current Opinion in Immunology. 22:185-192
αβ and γδ T cells develop in the thymus from a common precursor. Although lineages initially were defined by the type of TCR they express, it soon became clear that the TCR type per se does not play a deterministic role in the lineage decision, s
Autor:
Dolly B. Tyan, Yih Hsin Chang, Siske S. Struik, Kwadwo A. Koram, Daniel S. Korbel, Ming Yuh Shiau, Patricia A. Fraser, Kamran Hameed, Christine V.F. Carrington, Laurent Abi-Rached, Myoung Hee Park, Peter Parham, Ronald W. Davis, Robert Vaughan, Ketevan Gendzekhadze, Güher Saruhan-Direskeneli, Paul Norman, Mostafa Ronaghi, Nuria Matamoros, Dan Bruno, Don Rowley, Giorgi Kamkamidze, Catalina Crespí, D. Dan Ramdath, Henry A.F. Stephens, Dasdayanee Chandanayingyong, Ramasamy Pitchappan, Michael Gleimer, Joan Milà, Eleanor M. Riley, Zulay Layrisse, David H. Verity
Publikováno v:
Nature Genetics. 39:1092-1099
Interactions of killer cell immunoglobulin-like receptors (KIRs) with major histocompatibility complex (MHC) class I ligands diversify natural killer cell responses to infection. By analyzing sequence variation in diverse human populations, we show t
Autor:
Peter Parham, Michael Gleimer
Publikováno v:
Immunity. 19:469-477
The evolutionarily ancient intracellular stress response protects cells from the effects of external and internal forces which perturb cellular metabolism. Members of the major histocompatibility complex (MHC) class I-like superfamily act as cell sur
Autor:
Leonard A. Herzenberg, Li Sheng Lu, Leonore A. Herzenberg, Nicole Baumgarth, James W. Tung, Ometa C. Herman, Michael Gleimer
Publikováno v:
Proceedings of the National Academy of Sciences. 99:3007-3012
Studies presented here show that the expression of CD4, MHC class II (Ia,) and B220 cleanly resolves a major and a minor subset within the earliest pro-B cell population (germ-line pro-B) in adult bone marrow (BM). The major subset expresses intermed
Autor:
Michael Gleimer, Harald von Boehmer
Publikováno v:
Current Biology. 20(7):R316-R318
Summary The development and function of lymphocytes depend upon their precise migration in response to chemoattractant cytokines, or chemokines. Two recent reports suggest that, during thymic β-selection, the binding of the chemokine CXCL12 to the r
Autor:
Cornelis Murre, Taras Kreslavsky, Masaki Miyazaki, Piotr Sicinski, Michael Gleimer, Yoon Jong Choi, Harald von Boehmer, Etienne Gagnon
Publikováno v:
Immunity. 37(5)
SummaryProliferation and differentiation are tightly coordinated to produce an appropriate number of differentiated cells and often exhibit an antagonistic relationship. Developing T cells, which arise in the thymus from a minute number of bone-marro
Publikováno v:
Immunological reviews. 238(1)
Both αβ and γδ T cells develop in the thymus from a common progenitor. Historically distinguished by their T-cell receptor (TCR), these lineages are now defined on the basis of distinct molecular programs. Intriguingly, in many transgenic and kno