Zobrazeno 1 - 10
of 484
pro vyhledávání: '"Michael, Flentje"'
Autor:
Vanessa Rousseau, Elias Einig, Chao Jin, Julia Horn, Mathias Riebold, Tanja Poth, Mohamed-Ali Jarboui, Michael Flentje, Nikita Popov
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Replicative stress promotes genomic instability and tumorigenesis but also presents an effective therapeutic endpoint, rationalizing detailed analysis of pathways that control DNA replication. We show here that the transcription factor E2f4
Externí odkaz:
https://doaj.org/article/c38108c512d843568839ac3820e48a8c
Autor:
Marcus Zimmermann, Anne Richter, Stefan Weick, Florian Exner, Frederick Mantel, Markus Diefenhardt, Emmanouil Fokas, Rebekka Kosmala, Michael Flentje, Bülent Polat
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract In locally advanced rectal cancer (LARC) neoadjuvant chemoradiotherapy is regarded as standard treatment. We assessed acute toxicities in patients receiving conventional 3D-conformal radiotherapy (3D-RT) and correlated them with dosimetric p
Externí odkaz:
https://doaj.org/article/1ab33e795d984928a6c4f5496223ce98
Autor:
Johannes Kraft, Stefan Weick, Kathrin Breuer, Paul Lutyj, Klaus Bratengeier, Florian Exner, Anne Richter, Jörg Tamihardja, Dominik Lisowski, Bülent Polat, Michael Flentje
Publikováno v:
Radiation Oncology, Vol 17, Iss 1, Pp 1-10 (2022)
Externí odkaz:
https://doaj.org/article/74e68e68c3c94e34bcdc0c65702c0600
Autor:
Dominik Lisowski, Jannik Trömel, Paul Lutyj, Victor Lewitzki, Philipp E. Hartrampf, Bülent Polat, Michael Flentje, Jörg Tamihardja
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract This retrospective, single-institutional study investigated long-term outcome, toxicity and health-related quality of life (HRQoL) in meningioma patients after radiotherapy. We analyzed the data of 119 patients who received radiotherapy at o
Externí odkaz:
https://doaj.org/article/fa36ab567e3149fe95222de9460eb988
Autor:
Thomas Fischer, Oliver Hartmann, Michaela Reissland, Cristian Prieto-Garcia, Kevin Klann, Nikolett Pahor, Christina Schülein-Völk, Apoorva Baluapuri, Bülent Polat, Arya Abazari, Elena Gerhard-Hartmann, Hans-Georg Kopp, Frank Essmann, Mathias Rosenfeldt, Christian Münch, Michael Flentje, Markus E. Diefenbacher
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-22 (2022)
Abstract Background Despite advances in treatment of patients with non-small cell lung cancer, carriers of certain genetic alterations are prone to failure. One such factor frequently mutated, is the tumor suppressor PTEN. These tumors are supposed t
Externí odkaz:
https://doaj.org/article/6e2b77747e884b2d9b01fa05018ce46e
Autor:
Bülent Polat, Gisela Wohlleben, Rebekka Kosmala, Dominik Lisowski, Frederick Mantel, Victor Lewitzki, Mario Löhr, Robert Blum, Petra Herud, Michael Flentje, Camelia-Maria Monoranu
Publikováno v:
Cancer Cell International, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Despite of a multimodal approach, recurrences can hardly be prevented in glioblastoma. This may be in part due to so called glioma stem cells. However, there is no established marker to identify these stem cells. Methods Paired sa
Externí odkaz:
https://doaj.org/article/396c37a94c354d918bce3f486945a8f5
Autor:
Anne Richter, Sonja Wegener, Kathrin Breuer, Gary Razinskas, Stefan Weick, Florian Exner, Klaus Bratengeier, Michael Flentje, Otto Sauer, Bülent Polat
Publikováno v:
Radiation Oncology, Vol 16, Iss 1, Pp 1-9 (2021)
Abstract Background To implement a tangential treatment technique for whole breast irradiation using the Varian Halcyon and to compare it with Elekta Synergy Agility plans. Methods For 20 patients two comparable treatment plans with respect to dose c
Externí odkaz:
https://doaj.org/article/7b65f004c87240f1952754e3729a8009
Autor:
Cholpon S. Djuzenova, Thomas Fischer, Astrid Katzer, Dmitri Sisario, Tessa Korsa, Gudrun Steussloff, Vladimir L. Sukhorukov, Michael Flentje
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-20 (2021)
Abstract Background Radiotherapy is routinely used to combat glioblastoma (GBM). However, the treatment efficacy is often limited by the radioresistance of GBM cells. Methods Two GBM lines MO59K and MO59J, differing in intrinsic radiosensitivity and
Externí odkaz:
https://doaj.org/article/375fc4254eaa473e9b05d8942717fc41
Autor:
Jörg Tamihardja, Sinan Cirsi, Patrick Kessler, Gary Razinskas, Florian Exner, Anne Richter, Bülent Polat, Michael Flentje
Publikováno v:
Radiation Oncology, Vol 16, Iss 1, Pp 1-9 (2021)
Abstract Background Evaluation of delivered dose to the dominant intraprostatic lesion (DIL) for moderately hypofractionated radiotherapy of prostate cancer by cone beam computed tomography (CBCT)-based dose accumulation and target coverage analysis.
Externí odkaz:
https://doaj.org/article/4e01da81745e462ba9a687e8b9b83893
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundBoluses are routinely used in radiotherapy to modify surface doses. Nevertheless, considerable dose discrepancies may occur in some cases due to fit inaccuracy of commercially available standard flat boluses. Moreover, due to the simple geo
Externí odkaz:
https://doaj.org/article/ca567111ff1846ba88c1e9d15810a1ff