Dopamine signaling leads to loss of Polycomb repression and aberrant gene activation in experimental parkinsonism.

Autor: Erik Södersten, Michael Feyder, Mads Lerdrup, Ana-Luisa Gomes, Hanna Kryh, Giada Spigolon, Jocelyne Caboche, Gilberto Fisone, Klaus Hansen

Publikováno v: PLoS Genetics, Vol 10, Iss 9, p e1004574 (2014)

Polycomb group (PcG) proteins bind to and repress genes in embryonic stem cells through lineage commitment to the terminal differentiated state. PcG repressed genes are commonly characterized by the presence of the epigenetic histone mark H3K27me3, c

Externí odkaz: https://doaj.org/article/4ca99195eea0416ba9454d2441a1bfc1

Involvement of Autophagy in Levodopa‐Induced Dyskinesia

Autor: Carina Plewnia, Lidia Urbina, David Sulzer, Erwan Bezard, Mikael Altun, Michael Feyder, Benjamin Dehay, Anders Borgkvist, Per Nilsson, Qin Li, Giada Spigolon, Emanuela Santini, Alessandro Piccin, Gilberto Fisone, Ori J. Lieberman

Publikováno v: Movement Disorders
Movement Disorders, Wiley, 2021, Online ahead of print. ⟨10.1002/mds.28480⟩
Movement Disorders, 2021, Online ahead of print. ⟨10.1002/mds.28480⟩

Background Autophagy is intensively studied in cancer, metabolic and neurodegenerative diseases, but little is known about its role in pathological conditions linked to altered neurotransmission. We examined the involvement of autophagy in levodopa (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db06734382d3407f323778ea9b5f0938
https://www.hal.inserm.fr/inserm-03114552/document

Impaired associative fear learning in mice with complete loss or haploinsufficiency of AMPA GluR1 receptors

Autor: Michael Feyder, Lisa Wiedholz, Rolf Sprengel, Andrew Holmes

Publikováno v: Frontiers in Behavioral Neuroscience, Vol 1 (2007)

There is compelling evidence that L-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) glutamate receptors containing the GluR1 subunit contribute to the molecular mechanisms associated with learning. AMPA GluR1 glutamate receptor knockout m

Externí odkaz: https://doaj.org/article/195cfdfd01304ff7b761655ab1fd956d

A Role for Mitogen- and Stress-Activated Kinase 1 in L-DOPA –Induced Dyskinesia and ∆FosB Expression

Autor: Eric J. Nestler, Vincent Vialou, Michael Feyder, Emily L. Watts, Erik Södersten, Quincey LaPlant, Emanuela Santini, Jocelyne Caboche, Giada Spigolon, Gilberto Fisone, Klaus Hansen

Publikováno v: Biological Psychiatry
Biological Psychiatry, Elsevier, 2016, 79 (5), pp.362-371. ⟨10.1016/j.biopsych.2014.07.019⟩
Biological Psychiatry, 2016, 79 (5), pp.362-371. ⟨10.1016/j.biopsych.2014.07.019⟩

International audience; BACKGROUND: Abnormal regulation of extracellular signal-regulated kinases 1 and 2 has been implicated in 3,4-dihydroxy-L-phenylalanine (L-DOPA)-induced dyskinesia (LID), a motor complication affecting Parkinson's disease patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8130fb843800d0f6bb03dd4f842308
https://doi.org/10.1016/j.biopsych.2014.07.019

Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model

Autor: Débora Masini, Giada Spigolon, Enrique M. Toledo, Gilberto Fisone, Marius Wernig, Pia Rivetti di Val Cervo, Roman A. Romanov, Gioele La Manno, Elisa Martín-Montañez, Sten Linnarsson, Michael Feyder, Tibor Harkany, Sara Padrell Sánchez, Yi Han Ng, Ernest Arenas, Christian Pifl

Publikováno v: Nature Biotechnology

Cell replacement therapies for neurodegenerative disease have focused on transplantation of the cell types affected by the pathological process. Here we describe an alternative strategy for Parkinson's disease in which dopamine neurons are generated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dcefbc30ff0169351462595170a387a
https://pubmed.ncbi.nlm.nih.gov/28590561