Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Michael, F.A."'
Autor:
Michael, F.A., Hessz, D., Graf, C., Zimmer, C., Nour, S., Jung, M., Kloka, J., Knabe, M., Welsch, C., Blumenstein, I., Dultz, G., Finkelmeier, F., Walter, D., Mihm, U., Lingwal, N., Zeuzem, S., Bojunga, J., Friedrich-Rust, M.
Publikováno v:
In Journal of Clinical Anesthesia June 2024 94
Autor:
Varghese, Teena M., Dudas, Paul L., Allen, Samantha J., Schneeweis, Jonathan E., Finley, Michael F.A. *
Publikováno v:
In SLAS Discovery January 2021 26(1):122-129
Publikováno v:
In Biochemical Engineering Journal 15 January 2017 117 Part A:218-225
Autor:
Solly, Kelli, Klein, Rebecca, Rudd, Michael, Holloway, M. Katharine, Johnson, Eric N. *, Henze, Darrell, Finley, Michael F.A. **
Publikováno v:
In SLAS Discovery July 2015 20(6):708-719
Publikováno v:
ACS Chemical Biology. 14:567-578
Autor:
Ning Qin, Michael F.A. Finley, Christopher M. Flores, Michael P. Neeper, Michael P. Winters, Michael R. Brandt, Wall Mark, Nalin L. Subasinghe, Raymond W. Colburn, Zhihua Sui, Craig R. Schneider, Mary Lou Lubin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3780-3783
A novel series of pyrazolyltetrahydropyran N-type calcium channel blockers are described. Structural modifications of the series led to potent compounds in both a cell-based fluorescent calcium influx assay and a patch clamp electrophysiology assay.
Autor:
Teena M Varghese, Michael F.A. Finley, Samantha J Allen, Paul L. Dudas, Jonathan E Schneeweis
Publikováno v:
SLAS discovery : advancing life sciences RD. 26(1)
Interleukin-23 (IL-23) is a key cytokine implicated in the pathogenesis of autoimmune disorders, including psoriasis and ulcerative colitis. Although targeted IL-23 antibody therapeutics are used clinically, there are no small-molecule therapeutics t
Autor:
Douglas C. Beshore, Stephen Day, Jason Cassaday, Michelle F. Homsher, Brian Squadroni, David Pechter, Michelle Smith, Lei Ma, Jeffrey D. Hermes, Elizabeth Mohammed, Michelle Hartnett, Paul Zuck, Michael F.A. Finley, Victor N. Uebele, Fredrick Monsma
Publikováno v:
SLAS Discovery. 22:1060-1066
Agonist shift assays feature cross-titrations of allosteric modulators and orthosteric ligands. Information generated in agonist shift assays can include a modulator's effect on the orthosteric agonist's potency (alpha) and efficacy (beta), as well a
Autor:
Michelle F. Homsher, Louis Locco, Shannon L. Stahler, Michael Weber, Jennifer E. Nothstein, Eleftheria N. Finger, Evelyn Boots, Mee Ra Heo, Amita Patel, Gregory O'Donnell, Alex Wolicki, Michael F.A. Finley, J. Christopher Culberson, Paul Zuck, Juncai Meng, Kenneth Roberts, David J. Bell, Peter S. Kutchukian, Gregory C. Adam, Carissa Quinn, Patrick Cocchiarella, Meir Glick, S. Alex May, Victor N. Uebele, Edward Hudak, Brian Squadroni, Daniel Riley, Andrew Rusinko, Kelli Solly, Michelle Hartnett, Dante A. Pertusi, Adam Amoss, Anthony Kreamer, Tara White, Anne Mai Wassermann
Publikováno v:
SLAS Discovery. 22:995-1006
High-throughput screening (HTS) is a widespread method in early drug discovery for identifying promising chemical matter that modulates a target or phenotype of interest. Because HTS campaigns involve screening millions of compounds, it is often desi
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.