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of 1 238
pro vyhledávání: '"Michael, Dean"'
Autor:
Bonnita Werner, Elyse Powell, Jennifer Duggan, Marilisa Cortesi, Yeh Chen Lee, Vivek Arora, Ramanand Athavale, Michael Dean, Kristina Warton, Caroline E. Ford
Publikováno v:
Molecular Oncology, Vol 18, Iss 11, Pp 2668-2683 (2024)
The emergence of targeted therapies has transformed ovarian cancer treatment. However, biomarker profiling for precision medicine is limited by access to quality, tumour‐enriched tissue samples. The use of cell‐free DNA (cfDNA) in ascites present
Externí odkaz:
https://doaj.org/article/a862393c1ac74143b9221afef01ea9a5
Autor:
Mita Manna, Michelle Brabant, Rowen Greene, Michael Dean Chamberlain, Aalok Kumar, Nimira Alimohamed, Christine Brezden-Masley
Publikováno v:
Current Oncology, Vol 31, Iss 9, Pp 5694-5708 (2024)
Sacituzumab Govitecan (SG) is an antibody-drug conjugate (ADC) comprised of an anti-Trop-2 IgG1 molecule conjugated to SN-38, the active metabolite of irinotecan, via a pH-sensitive hydrolysable linker. As a result of recent Canadian funding for SG i
Externí odkaz:
https://doaj.org/article/7a6dcf3b67f148be83e018770a5a46ad
Somatic mutations in 3929 HPV positive cervical cells associated with infection outcome and HPV type
Autor:
Maisa Pinheiro, Nicolas Wentzensen, Michael Dean, Meredith Yeager, Zigui Chen, Amulya Shastry, Joseph F. Boland, Sara Bass, Laurie Burdett, Thomas Lorey, Sambit Mishra, Philip E. Castle, Mark Schiffman, Robert D. Burk, Bin Zhu, Lisa Mirabello
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Invasive cervical cancers (ICC), caused by HPV infections, have a heterogeneous molecular landscape. We investigate the detection, timing, and HPV type specificity of somatic mutations in 3929 HPV-positive exfoliated cervical cell samples fr
Externí odkaz:
https://doaj.org/article/c1bcd6c690174c39b5a8206f244b5eba
Autor:
María Cecilia Agudelo, Edmundo Torres-González, Samuel Agudelo, Arianis Tatiana Ramírez, Kelly Melisa Castañeda, Connor J. Kinslow, María Rodríguez-Herrera, Lisa Garland, Yi Xie, Carlos Alberto Orozco, Mark Stoler, Michael Dean, Gloria Inés Sánchez
Publikováno v:
Biomédica: revista del Instituto Nacional de Salud, Vol 44, Iss Sp. 1, Pp 101-109 (2024)
Introduction. Low-cost, accurate high-risk HPV tests are needed for cervical cancer screening in limited-resource settings. Objective. To compare the performance of the low-cost Hybribio-H13 test with the Hybrid Capture® 2 to detect cervical intraep
Externí odkaz:
https://doaj.org/article/ca22afbabc9a4896bc9883918120d5f9
Autor:
Zhenziang Fan, Kate F. Kernan, Yidi Qin, Scott Canna, Robert A. Berg, David Wessel, Murray M. Pollack, Kathleen Meert, Mark Hall, Christopher Newth, John C. Lin, Allan Doctor, Tom Shanley, Tim Cornell, Rick E. Harrison, Athena F. Zuppa, Katherine Sward, J. Michael Dean, H. J. Park, Joseph A. Carcillo
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-12 (2023)
Abstract Background One of five global deaths are attributable to sepsis. Hyperferritinemic sepsis (> 500 ng/mL) is associated with increased mortality in single-center studies. Our pediatric research network’s objective was to obtain rationale for
Externí odkaz:
https://doaj.org/article/dc1f2d5909cd4b9fa2e610b7b3a2910d
Autor:
Zinna, Shairbanu S., Morgan, Ryan W., Reeder, Ron W., Ahmed, Tageldin, Bell, Michael J., Bishop, Robert, Bochkoris, Matthew, Burns, Candice, Carcillo, Joseph A., Carpenter, Todd C., Cooper, Kellimarie K., Michael Dean, J., Wesley Diddle, J., Federman, Myke, Fernandez, Richard, Fink, Ericka L., Franzon, Deborah, Frazier, Aisha H., Friess, Stuart H., Graham, Kathryn, Hall, Mark, Harding, Monica L., Hehir, David A., Horvat, Christopher M., Huard, Leanna L., Landis, William P., Maa, Tensing, Manga, Arushi, McQuillen, Patrick S., Meert, Kathleen L., Mourani, Peter M, Nadkarni, Vinay M., Naim, Maryam Y., Notterman, Daniel, Pollack, Murray M., Sapru, Anil, Schneiter, Carleen, Sharron, Matthew P., Srivastava, Neeraj, Tilford, Bradley, Viteri, Shirley, Wessel, David, Wolfe, Heather A., Yates, Andrew R., Zuppa, Athena F., Berg, Robert A., Sutton, Robert M.
Publikováno v:
In Resuscitation January 2024 194
Growing out of recent pedagogical developments in creative writing studies and perceived barriers to teaching the subject in secondary education schools, this book creates conversations between secondary and post-secondary teachers aimed at introduci
Akademický článek
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Spatially resolved gene regulatory and disease-related vulnerability map of the adult Macaque cortex
Autor:
Ying Lei, Mengnan Cheng, Zihao Li, Zhenkun Zhuang, Liang Wu, Yunong sun, Lei Han, Zhihao Huang, Yuzhou Wang, Zifei Wang, Liqin Xu, Yue Yuan, Shang Liu, Taotao Pan, Jiarui Xie, Chuanyu Liu, Giacomo Volpe, Carl Ward, Yiwei Lai, Jiangshan Xu, Mingyue Wang, Hao Yu, Haixi Sun, Qichao Yu, Chunqing Wang, Chi Wai Wong, Wei Liu, Liangzhi Xu, Jingkuan Wei, Dandan Chen, Zhouchun Shang, Guibo Li, Kun Ma, Le Cheng, Fei Ling, Tao Tan, Kai Chen, Bosiljka Tasic, Michael Dean, Weizhi Ji, Huanming Yang, Ying Gu, Miguel A. Esteban, Yuxiang Li, Ao Chen, Yuyu Niu, Hongkui Zeng, Yong Hou, Longqi Liu, Shiping Liu, Xun Xu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Cell type epigenetic and topographic information of primate brain is lacking. Here, authors identified transcriptional regulatory network, gradient expression pattern and disease vulnerability at cell type level in PFC, M1 and V1 of monkey brain by s
Externí odkaz:
https://doaj.org/article/0ab4d766decf4a70b2a80a3a8ff72b4b
Autor:
Gabriel J Starrett, Kelly Yu, Yelena Golubeva, Petra Lenz, Mary L Piaskowski, David Petersen, Michael Dean, Ajay Israni, Brenda Y Hernandez, Thomas C Tucker, Iona Cheng, Lou Gonsalves, Cyllene R Morris, Shehnaz K Hussain, Charles F Lynch, Reuben S Harris, Ludmila Prokunina-Olsson, Paul S Meltzer, Christopher B Buck, Eric A Engels
Publikováno v:
eLife, Vol 12 (2023)
A small percentage of bladder cancers in the general population have been found to harbor DNA viruses. In contrast, up to 25% of tumors of solid organ transplant recipients, who are at an increased risk of developing bladder cancer and have an overal
Externí odkaz:
https://doaj.org/article/276cdac8c65046efa937353d38e5f7ca