Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Michael, Costigan"'
Autor:
Yildirim Ozdemir, Kazuo Nakamoto, Bruno Boivin, Daniel Bullock, Nick A. Andrews, Rafael González-Cano, Michael Costigan
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Chronic pain occurs at epidemic levels throughout the population. Hypersensitivity to touch, is a cardinal symptom of chronic pain. Despite dedicated research for over a century, quantifying this hypersensitivity has remained impossible at scale. To
Externí odkaz:
https://doaj.org/article/5d27109358424a11bbe65bcdcb955e54
Autor:
Maya Chopra, Dustin L. Gable, Jamie Love‐Nichols, Alexa Tsao, Shira Rockowitz, Piotr Sliz, Elizabeth Barkoudah, Lucia Bastianelli, David Coulter, Emily Davidson, Claudio DeGusmao, David Fogelman, Kathleen Huth, Paige Marshall, Donna Nimec, Jessica Solomon Sanders, Benjamin J. Shore, Brian Snyder, Scellig S. D. Stone, Ana Ubeda, Colyn Watkins, Charles Berde, Jeffrey Bolton, Catherine Brownstein, Michael Costigan, Darius Ebrahimi‐Fakhari, Abbe Lai, Anne O'Donnell‐Luria, Alex R. Paciorkowski, Anna Pinto, John Pugh, Lance Rodan, Eugene Roe, Lindsay Swanson, Bo Zhang, Michael C. Kruer, Mustafa Sahin, Annapurna Poduri, Siddharth Srivastava
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 2, Pp 193-205 (2022)
Abstract Objectives Cerebral palsy (CP) is the most common childhood motor disability, yet its link to single‐gene disorders is under‐characterized. To explore the genetic landscape of CP, we conducted whole exome sequencing (WES) in a cohort of
Externí odkaz:
https://doaj.org/article/15b21aa620bf4d56a284aca4377297fb
Autor:
Alexandra Latini, Michael Costigan
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/1f92b6e7175c4a31b6d13aebebce2b7b
Autor:
Rafael Gonzalez-Cano, Ángeles Montilla-García, Gloria Perazzoli, Jesús M. Torres, Francisco J. Cañizares, Eduardo Fernández-Segura, Michael Costigan, José M. Baeyens, Enrique J. Cobos
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Both TRPA1 and purinergic P2X receptors have been proposed as potential targets for the treatment of visceral pain. We found that the intracolonic administration of a low dose mustard oil (0.5%), a well-known TRPA1 agonist, produced nociceptive respo
Externí odkaz:
https://doaj.org/article/087deb144f414e6f8565cd3f2e03fe46
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Cytotoxicity and consequent cell death pathways are a critical component of the immune response to infection, disease or injury. While numerous examples of inflammation causing neuronal sensitization and pain have been described, there is a growing a
Externí odkaz:
https://doaj.org/article/7ea83cbfd053454097c2bdc602af5717
Autor:
Enrique J. Cobos, Chelsea A. Nickerson, Fuying Gao, Vijayendran Chandran, Inmaculada Bravo-Caparrós, Rafael González-Cano, Priscilla Riva, Nick A. Andrews, Alban Latremoliere, Corey R. Seehus, Gloria Perazzoli, Francisco R. Nieto, Nicole Joller, Michio W. Painter, Chi Him Eddie Ma, Takao Omura, Elissa J. Chesler, Daniel H. Geschwind, Giovanni Coppola, Manu Rangachari, Clifford J. Woolf, Michael Costigan
Publikováno v:
Cell Reports, Vol 22, Iss 5, Pp 1301-1312 (2018)
Summary: Chronic neuropathic pain is a major morbidity of neural injury, yet its mechanisms are incompletely understood. Hypersensitivity to previously non-noxious stimuli (allodynia) is a common symptom. Here, we demonstrate that the onset of cold h
Externí odkaz:
https://doaj.org/article/13a9fb8f80d74f569011eeba624c7454
Autor:
Véronique Lisi, Bhagat Singh, Michel Giroux, Elmer Guzman, Michio W. Painter, Yung-Chih Cheng, Eric Huebner, Giovanni Coppola, Michael Costigan, Clifford J. Woolf, Kenneth S. Kosik
Publikováno v:
Cell Reports, Vol 20, Iss 5, Pp 1136-1147 (2017)
Summary: Peripheral nerve regeneration after injury requires a broad program of transcriptional changes. We investigated the basis for the enhanced nerve regenerative capacity of the CAST/Ei mouse strain relative to C57BL/6 mice. RNA sequencing of do
Externí odkaz:
https://doaj.org/article/a39f43325083432fa937c1852723fffe
Autor:
Christine B. Sieberg, Caitlin Taras, Aya Gomaa, Chelsea Nickerson, Cindy Wong, Catherine Ward, Georgios Baskozos, David L.H. Bennett, Juan D. Ramirez, Andreas C. Themistocleous, Andrew S.C. Rice, Pallai R. Shillo, Solomon Tesfaye, Robert R. Edwards, Nick A. Andrews, Charles Berde, Michael Costigan
Publikováno v:
PAIN Reports, Vol 3, Iss 3, p e651 (2018)
Abstract. Background:. Epidemiological studies in patients with neuropathic pain demonstrate a strong association with psychiatric conditions such as anxiety; however, the precipitating pathology between these symptoms remains unclear. To investigate
Externí odkaz:
https://doaj.org/article/d796a7371a9c47d1b0d2d26854c89cea
Autor:
Rafael Gonzalez-Cano, Bruno Boivin, Daniel Bullock, Laura Cornelissen, Nick Andrews, Michael Costigan
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Most pathological pain conditions in patients and rodent pain models result in marked alterations in mechanosensation and the gold standard way to measure this is by use of von Frey fibers. These graded monofilaments are used to gauge the level of st
Externí odkaz:
https://doaj.org/article/3a88b33f7d1d41098228ed5bc0c6254c
Autor:
Tomohiro Banno, Takao Omura, Noritaka Masaki, Hideyuki Arima, Dongmin Xu, Ayako Okamoto, Michael Costigan, Alban Latremoliere, Yukihiro Matsuyama, Mitsutoshi Setou
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177595 (2017)
Peripheral nerve injury induces substantial molecular changes in the somatosensory system that leads to maladaptive plasticity and cause neuropathic pain. Understanding the molecular pathways responsible for the development of neuropathic pain is ess
Externí odkaz:
https://doaj.org/article/44fe9518fb7647eebdfe910ceea3a8b4