Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Michael, Calhoun"'
Autor:
Brenda Amaral, Andrew Capacci, Trip Anderson, Ceren Tezer, Bekim Bajrami, Mukesh Lulla, Brian Lucas, Jayanth V. Chodaparambil, Douglas Marcotte, P. Rajesh Kumar, Paramasivam Murugan, Kerri Spilker, Mike Cullivan, Ti Wang, Anton C. Peterson, Istvan Enyedy, Bin Ma, TeYu Chen, Zain Yousaf, Michael Calhoun, Olga Golonzhka, Gregory M. Dillon, Samir Koirala
Publikováno v:
ACS Chemical Neuroscience. 14:1080-1094
Autor:
Gregory M Dillon, Jaclyn L Henderson, Channa Bao, John A Joyce, Michael Calhoun, Brenda Amaral, Kristopher W King, Bekim Bajrami, Dania Rabah
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0228771 (2020)
Hyperphosphorylated tau protein is a pathological hallmark of numerous neurodegenerative diseases and the level of tau pathology is correlated with the degree of cognitive impairment. Tau hyper-phosphorylation is thought to be an early initiating eve
Externí odkaz:
https://doaj.org/article/4ad3843a90eb46f59942329ffdb2df81
Autor:
Elizabeth R. Spencer, Wen Shi, Robert W. Komorowski, James P. Gilbert, Lauren M. Ostrowski, Lynne M. Bird, Ronald Thibert, Channa Bao, Fiona Molloy, Michael Calhoun, Samir Koirala, Paymaan Jafar-nejad, Frank Rigo, Mark A. Kramer, Catherine J. Chu
Publikováno v:
Brain communications. 4(3)
Angelman syndrome is a neurodevelopmental disorder caused by deficiency of the maternally inherited UBE3A gene in neurons. Antisense oligonucleotide therapies are under development to reinstate UBE3A protein production. Non-invasive biomarkers to det
Autor:
Kristopher W King, Brenda Amaral, Eli Schuman, LaiYee Wong, Michael Rooney, Marta Nevalainen, Jun Feng, Paramasivam Murugan, Jayanth V. Chodaparambil, Thomas A. Patterson, Hannah Certo, Martin K Himmelbauer, Rab Gilfillan, Tamara Halkina, Sarah Lamore, J Howard Jones, Douglas Marcotte, Gregory M Dillon, Jaclyn L. Henderson, Thomas Hesson, P Rajesh Kumar, Edward Yin-Shiang Lin, Channa Bao, Felix Gonzalez-Lopez de Turiso, Joshua L Johnson, Michael Calhoun
Publikováno v:
Journal of medicinal chemistry. 64(9)
Structural analysis of the known NIK inhibitor 3 bound to the kinase domain of TTBK1 led to the design and synthesis of a novel class of azaindazole TTBK1 inhibitors exemplified by 8 (cell IC50: 571 nM). Systematic optimization of this series of anal
Autor:
Dania Rabah, Channa Bao, Gregory M Dillon, Jaclyn L. Henderson, Bekim Bajrami, Michael Calhoun, Kristopher W King, Brenda Amaral, John A. Joyce
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0228771 (2020)
PLoS ONE
PLoS ONE
Hyperphosphorylated tau protein is a pathological hallmark of numerous neurodegenerative diseases and the level of tau pathology is correlated with the degree of cognitive impairment. Tau hyper-phosphorylation is thought to be an early initiating eve
Autor:
Barry Smith, Sivaram Arabandi, Mathias Brochhausen, Michael Calhoun, Paolo Ciccarese, Scott Doyle, Bernard Gibaud, Ilya Goldberg, Charles E Kahn, James Overton, John Tomaszewski, Metin Gurcan
Publikováno v:
Journal of Pathology Informatics, Vol 6, Iss 1, Pp 37-37 (2015)
Background: Ontology is one strategy for promoting interoperability of heterogeneous data through consistent tagging. An ontology is a controlled structured vocabulary consisting of general terms (such as "cell" or "image" or "tissue" or "microscope"
Externí odkaz:
https://doaj.org/article/68ced276e34144b38866094c366c8f41
Autor:
Steven M, Grauer, Raul, Sanoja, Dominic, Poulin, Harunor, Rashid, Nina, Jochnowitz, Michael, Calhoun, Daniel, Zwilling, Geoffrey B, Varty, Thomas W, Rosahl, Hamid, Meziane, Christopher, Mittlelhaeuser, Robert, Mazzola, John, Morrow, Sean M, Smith, Darrell, Henze, Jacob, Marcus
Publikováno v:
Brain research. 1737
Analgesic properties of orthosteric agonists of the muscarinic M
Autor:
John A. Morrow, Raul Sanoja, Jacob Marcus, Daniel Zwilling, Darrell A. Henze, Nina Jochnowitz, Christopher Mittlelhaeuser, Robert Mazzola, Michael Calhoun, Hamid Meziane, Harunor Rashid, Dominic Poulin, Sean M. Smith, Thomas W. Rosahl, Geoffrey B. Varty, Steven M. Grauer
Publikováno v:
Brain Research. 1737:146814
Analgesic properties of orthosteric agonists of the muscarinic M4 receptor subtype have been documented in literature reports, with evidence from pharmacological and in vivo receptor knock out (KO) studies. Constitutive M4 receptor KO mice demonstrat
Autor:
Dennis Dalli, Razvan Rusovici, Michael S. Grace, Gary Ganiban, Michael Calhoun, Kunal Mitra, Rudy A. Mazzocchi
Publikováno v:
International Journal for Numerical Methods in Biomedical Engineering. 33
A new retinal reattachment surgical procedure is based on a stent that is deployed to press the retina back in place. An eye-stent finite element model studied the strain induced by the stent on retina. Finite element model simulations were performed
Autor:
Olga Golonzhka, Michael Rooney, Greg Dillon, Christopher Rowbottom, Richard Grater, Kristopher W King, Michael Calhoun
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S31