Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Michael, Beekes"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Since the beginning prion research has been largely dependent on animal models for deciphering the disease, drug development or prion detection and quantification. Thereby, ethical as well as cost and labour-saving aspects call for alternati
Externí odkaz:
https://doaj.org/article/75890684a65d44119a1311e6828b8d8b
Autor:
Jan P. M. Langeveld, Anne Balkema-Buschmann, Dieter Becher, Achim Thomzig, Romolo Nonno, Olivier Andréoletti, Aart Davidse, Michele A. Di Bari, Laura Pirisinu, Umberto Agrimi, Martin H. Groschup, Michael Beekes, Jason Shih
Publikováno v:
Veterinary Research, Vol 52, Iss 1, Pp 1-12 (2021)
Abstract The unconventional infectious agents of transmissible spongiform encephalopathies (TSEs) are prions. Their infectivity co-appears with PrPSc, aberrant depositions of the host’s cellular prion protein (PrPC). Successive heat treatment in th
Externí odkaz:
https://doaj.org/article/aa07eb6e1137425a916e8bff065d7284
Preserving prion strain identity upon replication of prions in vitro using recombinant prion protein
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract Last decade witnessed an enormous progress in generating authentic infectious prions or PrPSc in vitro using recombinant prion protein (rPrP). Previous work established that rPrP that lacks posttranslational modification is able to support r
Externí odkaz:
https://doaj.org/article/9f8d973d32fc44b3adf47260e4a51a43
Publikováno v:
Pathogens, Vol 10, Iss 8, p 1060 (2021)
There are various existing cell models for the propagation of animal prions. However, in vitro propagation of human prions has been a long-standing challenge. This study presents the establishment of a long-term primary murine glia culture expressing
Externí odkaz:
https://doaj.org/article/15f120081eb24105b09d6f5ca34ebf00
Autor:
Michael Beekes
Publikováno v:
Viruses, Vol 13, Iss 7, p 1394 (2021)
A neuropathological hallmark of Parkinson’s disease (PD) is the cerebral deposition of abnormally aggregated α-synuclein (αSyn). PD-associated αSyn (αSynPD) aggregates are assumed to act, in a prion-like manner, as proteinaceous nuclei (“seed
Externí odkaz:
https://doaj.org/article/47737876330242489c91874b87db5c08
Autor:
Maria I. Arifin, Lech Kaczmarczyk, Doris Zeng, Samia Hannaoui, Chi Lee, Sheng Chun Chang, Gordon Mitchell, Debbie McKenzie, Michael Beekes, Walker Jackson, Sabine Gilch
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Prions are proteinaceous infectious particles that replicate by structural conversion of the host-encoded cellular prion protein (PrP C ), causing fatal neurodegenerative diseases in mammals. Species-specific amino acid substitutions (AAS) arising fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0100b5e3a4b7d3717b5386ceb267a535
https://doi.org/10.1073/pnas.2221060120
https://doi.org/10.1073/pnas.2221060120
Autor:
Steffen Halbgebauer, Samir Abu-Rumeileh, Patrick Oeckl, Petra Steinacker, Francesco Roselli, Diana Wiesner, Angela Mammana, Michael Beekes, Izaro Kortazar-Zubizarreta, Guiomar Perez de Nanclares, Sabina Capellari, Armin Giese, Joaquin Castilla, Albert C. Ludolph, Dana Žáková, Piero Parchi, Markus Otto
Publikováno v:
Neurology. 98:e1434-e1445
Background and ObjectivesFor early diagnosis and disease monitoring of neurodegenerative diseases (NDs), reliable blood biomarkers are needed. Elevated levels of neurofilament light chain protein (NfL), an axonal damage marker, have been described ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceacf12e84f251c194cc1296fc5bcfe4
https://doi.org/10.1212/wnl.0000000000200002
https://doi.org/10.1212/wnl.0000000000200002
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-2 (2018)
Figure 6 of the original publication [1] contained an error in the Wavenumber in panels B and C. The wavenumbers 1616 (Cm-1) in panels B and C should have been 1516 (cm-1). The updated figure has been published in this correction article; the origina
Externí odkaz:
https://doaj.org/article/43eef34836dd4808a07e6c928ce2b9da
Publikováno v:
Journal of Hospital Infection. 108:25-32
Summary Background Cerebral deposition of abnormally misfolded and aggregated alpha-synuclein (αSyn) is a neuropathological hallmark of Parkinson's disease (PD). Pathologically aggregated αSyn species of PD (αSynPD) can act, in a ‘prion-like’
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11cd8d219f06da5a18250ba3e88e31e
https://doi.org/10.1016/j.jhin.2020.10.018
https://doi.org/10.1016/j.jhin.2020.10.018
Autor:
Susanne Krasemann, Giulia Mearini, Elisabeth Krämer, Katja Wagenführ, Walter Schulz-Schaeffer, Melanie Neumann, Walter Bodemer, Franz-Josef Kaup, Michael Beekes, Lucie Carrier, Adriano Aguzzi, Markus Glatzel
Publikováno v:
Emerging Infectious Diseases, Vol 19, Iss 6, Pp 985-988 (2013)
Prion amyloidosis occurred in the heart of 1 of 3 macaques intraperitoneally inoculated with bovine spongiform encephalopathy prions. This macaque had a remarkably long duration of disease and signs of cardiac distress. Variant Creutzfeldt-Jakob dise
Externí odkaz:
https://doaj.org/article/1c7595f00e8d455ea2b620483742f955