Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Michael, Baltezor"'
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Pancreatic cancer is a devastating disease with a dismal prognosis and poor treatment outcomes. Searching for new agents for pancreatic cancer treatment is of great significance. We previously identified a novel activity of compound C150 to inhibit p
Externí odkaz:
https://doaj.org/article/d5e370f443d7474b992b7416b07bf444
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Pancreatic cancer cell epithelial-to-mesenchymal transition (EMT) is an important contributor to cell invasion and tumor progression. Therefore, targeting EMT may be beneficial for pancreatic cancer treatment. The aim of the present study was to repo
Externí odkaz:
https://doaj.org/article/9b879f6d38104a6bbce3b648f7625ba8
Publikováno v:
Drug Delivery and Translational Research. 13:503-519
This report describes local administration of large surface area microparticle docetaxel (LSAM-DTX: ~ 3.5- to 7.5-µm-sized particles with high relative surface area) in preclinical oncology models and in a clinical trial in urothelial carcinoma. Red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1612c01a9530364e6fdb17ddd889ad3
https://doi.org/10.1007/s13346-022-01226-2
https://doi.org/10.1007/s13346-022-01226-2
Fosciclopirox suppresses growth of high-grade urothelial cancer by targeting the γ-secretase complex
Autor:
Mehmet Tanol, Scott Weir, William McCulloch, Prasad Dandawate, Shrikant Anant, Parthasarathy Rangarajan, Roy A. Jensen, David Standing, Prabhu Ramamoorthy, Michael Baltezor, Amanda E. Brinker, Michael Dalton, Robyn Wood, Gregory A. Reed, Tammy Ham, Benjamin L. Woolbright, John A. Taylor, Sangita Bhattacharyya
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-20 (2021)
Cell Death & Disease
Cell Death & Disease
Ciclopirox (CPX) is an FDA-approved topical antifungal agent that has demonstrated preclinical anticancer activity in a number of solid and hematologic malignancies. Its clinical utility as an oral anticancer agent, however, is limited by poor oral b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f456beee3cc0052f3b820506a2f38f
https://doaj.org/article/d4bbf6c8245447f1b012189797bdb6c4
https://doaj.org/article/d4bbf6c8245447f1b012189797bdb6c4
Autor:
Xinbo Luo, Bart Lutterbach, Priya Pancholi, Yeon Sook Choi, Xiao Liu, Phillip Munson, Saqib Faisal, David A. Whipple, Robert A. Smith, Warren S. Weiner, David K. Johnson, Myriam Boukhali, Nicole S. Persky, Matthew G. Rees, Shunsuke Kitajima, David Barbie, Anuradha Roy, Michael Baltezor, Lian Rajewski, William McGuinness, John Haslam, Ananthan Sadagopan, Charles H. Yoon, Cory M. Johannessen, Christine G. Lian, Jason L. Hornick, Srinivas R. Viswanathan, David Liu, Vicki Nienaber, Wilhelm Haas, Frank J. Schoenen, David E. Fisher, Rizwan Haq
Publikováno v:
Cancer Research. 83:1706-1706
The transcription factor NRF2 is a master regulator of cellular responses to oxidative stress, contributing to the pathogenesis of autoimmunity, metabolic disorders, and neurodegeneration. Somatic alterations in the NRF2 pathway also contribute to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0e04d0b7c12a4af9fee06850f1e9b16
https://doi.org/10.1158/1538-7445.am2023-1706
https://doi.org/10.1158/1538-7445.am2023-1706
Autor:
Alison Wendt, Sam Campbell, Gere S. diZerega, Marc Iacobucci, Michael Baltezor, Holly Maulhardt, Paul Dorman, Shelagh Verco, Alyson Marin, Emily Williams, James Verco
Publikováno v:
Drug Delivery and Translational Research
This report describes local administration of submicron particle paclitaxel (SPP) (NanoPac®: ~ 800-nm-sized particles with high relative surface area with each particle containing ~ 2 billion molecules of paclitaxel) in preclinical models and clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f1c3dd27f0fa98d945d6a630ab405cf
https://doi.org/10.1007/s13346-020-00868-4
https://doi.org/10.1007/s13346-020-00868-4
Autor:
Amanda E. Brinker, Tammy Ham, Gregory A. Reed, Kathy Heppert, Lian G. Rajewski, John A. Taylor, William McCulloch, Roy A. Jensen, Karl Schorno, Shrikant Anant, Michael Dalton, Scott Weir, Michael Baltezor, Robyn Wood, Prabhu Ramamoorthy, Michael J. McKenna, Mehmet Tanol
Publikováno v:
J Pharmacol Exp Ther
Brinker, Amanda/0000-0003-1134-0572; Weir, Scott/0000-0002-8020-434X WOS:000477702600002 PubMed: 31113837 Pharmacokinetic studies in rats and dogs were performed to characterize the in vivo performance of a novel prodrug, fosciclopirox. Ciclopirox ol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3926e20ca9e59b65eab474660a87062a
https://doi.org/10.1124/jpet.119.257972
https://doi.org/10.1124/jpet.119.257972
Autor:
Michael Baltezor, Jeffrey A. Toretsky, Katherine Chastain, Scott Weir, Jennifer Crow, Lian G. Rajewski, Yan Ma, Vincent S. Staggs, Andrew K. Godwin, Glenson Samuel
Publikováno v:
J Mol Med (Berl)
Ewing sarcoma (ES) are aggressive pediatric bone and soft tissue tumors driven by EWS-ETS fusion oncogenes, most commonly EWS-FLI1. Treatment of ES patients consists of up to 9 months of alternating courses of 2 chemotherapeutic regimens. Furthermore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d714ca537aaa8b5d764594867232a422
https://doi.org/10.1007/s00109-019-01782-0
https://doi.org/10.1007/s00109-019-01782-0
Autor:
Anita Lopez, Andrew P. Gigliotti, James Verco, Philip J. Kuehl, Gere S. diZerega, William Johnston, Michael Baltezor, Steven A. Belinsky, Lauren Hylle, Ronald Wolff
Publikováno v:
Journal of Aerosol Medicine and Pulmonary Drug Delivery
Background: Inhaled chemotherapeutics may enhance pulmonary drug exposure to malignant lesions in the lung without substantially contributing to systemic toxicities. The pharmacokinetic profile of inhaled submicron particle paclitaxel (NanoPac®) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::988476129b75b903dea1af12a4167397
https://doi.org/10.1089/jamp.2018.1467
https://doi.org/10.1089/jamp.2018.1467
Autor:
Deborah J. Tate, Lian G. Rajewski, Charles J. Decedue, Carolyn J. Henry, Brian K. Flesner, Jeffrey N. Bryan, Jahna C. Espinosa, Michael Baltezor, Sandra M. Bechtel, Kim A. Selting
Publikováno v:
Veterinary and Comparative Oncology. 16:650-657
Carriers used to solubilize taxane chemotherapy drugs cause severe hypersensitivity. Nanoparticle formulations can provide improved dissolution and bioavailability of taxanes. Thus, a nanoparticulate, excipient-free formulation of paclitaxel (CTI5201
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a9cd391c86d6e59ade90399eaf2985
https://doi.org/10.1111/vco.12435
https://doi.org/10.1111/vco.12435