Výsledky vyhledávání - "Micha Schwikardi"

Use of site-specific recombination as a probe of nucleoprotein complex formation in chromatin

Publikováno v: European Journal of Biochemistry. 268:6256-6262

DNA transactions in eukaryotes require that proteins gain access to target sequences packaged in chromatin. Further, interactions between distinct nucleoprotein complexes are often required to generate higher-order structures. Here, we employed two p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbe2cf29d227cb0e0f45f69b55ac4582
https://doi.org/10.1046/j.0014-2956.2001.02579.x

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Site-specific recombination in human cells catalyzed by phage λ integrase mutants 1 1E. Lorbach and N. Christ contributed equally to this work. 2 2Edited by M.Yaniv

Autor: Elke Lorbach, Peter Dröge, Nicole Christ, Micha Schwikardi

Publikováno v: Journal of Molecular Biology. 296:1175-1181

Phage lambda Integrase (Int) is the prototype of the so-called integrase family of conservative site-specific recombinases, which includes Cre and FLP. The natural function of Int is to execute integration and excision of the phage into and out of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93fc1be8f6380d52a07f7f12620fb60c
https://doi.org/10.1006/jmbi.2000.3532

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A DNA-binding domain swap converts the invertase gin into a resolvase

Autor: Micha Schwikardi, Frank Schneider, Peter Dröge, Georgi Muskhelishvili

Publikováno v: Journal of Molecular Biology. 295:767-775

DNA resolvases and invertases are closely related, yet catalyze recombination within two distinct nucleoprotein structures termed synaptosomes and invertasomes, respectively. Different protein-protein and protein-DNA interactions guide the assembly o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea662e2fcb3f5f32e703c36082abc4c
https://doi.org/10.1006/jmbi.1999.3412

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Site-specific recombination in mammalian cells catalyzed by γδ resolvase mutants: implications for the topology of episomal DNA

Autor: Micha Schwikardi, Peter Dröge

Publikováno v: FEBS Letters. (2-3):147-150

We have transferred the prokaryotic gammadelta resolvase system to mammalian cells and present a comparative analysis of recombination by wild-type and two mutant resolvases (E124Q and E102Y/E124Q). Transient co-transfection assays using beta-galacto

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