Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Micha Drukker"'
Autor:
Daphna Mokady, Jason Charish, Patrick Barretto-Burns, Kenneth N. Grisé, Brenda L. K. Coles, Susanne Raab, Arturo Ortin-Martinez, Alex Müller, Bernhard Fasching, Payal Jain, Micha Drukker, Derek van der Kooy, Matthias Steger
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1521 (2024)
Degenerative retinal diseases associated with photoreceptor loss are a leading cause of visual impairment worldwide, with limited treatment options. Phenotypic profiling coupled with medicinal chemistry were used to develop a small molecule with prol
Externí odkaz:
https://doaj.org/article/52c1c22b770c4c6e9d3d737724110ca2
Autor:
Vera Zywitza, Ejona Rusha, Dmitry Shaposhnikov, Jorge Ruiz-Orera, Narasimha Telugu, Valentyna Rishko, Masafumi Hayashi, Geert Michel, Lars Wittler, Jan Stejskal, Susanne Holtze, Frank Göritz, Robert Hermes, Jichang Wang, Zsuzsanna Izsvák, Silvia Colleoni, Giovanna Lazzari, Cesare Galli, Thomas B. Hildebrandt, Katsuhiko Hayashi, Sebastian Diecke, Micha Drukker
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract The northern white rhinoceros (NWR) is probably the earth’s most endangered mammal. To rescue the functionally extinct species, we aim to employ induced pluripotent stem cells (iPSCs) to generate gametes and subsequently embryos in vitro.
Externí odkaz:
https://doaj.org/article/7d2718019bd844b08e9b1dd694becabd
Autor:
Vera Zywitza, Silke Frahm, Norman Krüger, Anja Weise, Frank Göritz, Robert Hermes, Susanne Holtze, Silvia Colleoni, Cesare Galli, Micha Drukker, Thomas B. Hildebrandt, Sebastian Diecke
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105414- (2022)
Summary: Less than 80 Sumatran rhinos (SR, Dicerorhinus sumatrensis) are left on earth. Habitat loss and limited breeding possibilities are the greatest threats to the species and lead to a continuous population decline. To stop the erosion of geneti
Externí odkaz:
https://doaj.org/article/e864e8879ab74a50bf08092a86c21805
Autor:
Markus Grosch, Sebastian Ittermann, Ejona Rusha, Tobias Greisle, Chaido Ori, Dong-Jiunn Jeffery Truong, Adam C. O’Neill, Anna Pertek, Gil Gregor Westmeyer, Micha Drukker
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-19 (2020)
Abstract Background Many long noncoding RNAs (lncRNAs) have been implicated in general and cell type-specific molecular regulation. Here, we asked what underlies the fundamental basis for the seemingly random appearance of nuclear lncRNA condensates
Externí odkaz:
https://doaj.org/article/788b174df5464e928832d41019e66b5d
Autor:
Pavel Kielkowski, Isabel Y. Buchsbaum, Volker C. Kirsch, Nina C. Bach, Micha Drukker, Silvia Cappello, Stephan A. Sieber
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Protein AMPylation is a post-translational modification whose implications in cellular physiology are not fully understood. Here the authors develop a cell-permeable AMPylation probe and use it to identify new AMP modified proteins and investigate th
Externí odkaz:
https://doaj.org/article/dc0d7f0727124aa5ad2c40e99753071c
Autor:
Fatma Uzbas, Florian Opperer, Can Sönmezer, Dmitry Shaposhnikov, Steffen Sass, Christian Krendl, Philipp Angerer, Fabian J. Theis, Nikola S. Mueller, Micha Drukker
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-16 (2019)
Abstract We describe a highly sensitive, quantitative, and inexpensive technique for targeted sequencing of transcript cohorts or genomic regions from thousands of bulk samples or single cells in parallel. Multiplexing is based on a simple method tha
Externí odkaz:
https://doaj.org/article/aff102b32c8b49f1a559718cb9e030ed
Autor:
Friederike Matheus, Ejona Rusha, Rizwan Rehimi, Lena Molitor, Anna Pertek, Miha Modic, Regina Feederle, Andrew Flatley, Elisabeth Kremmer, Arie Geerlof, Valentyna Rishko, Alvaro Rada-Iglesias, Micha Drukker
Publikováno v:
Stem Cell Reports, Vol 12, Iss 5, Pp 861-868 (2019)
Summary: The neural crest (NC) gives rise to a multitude of fetal tissues, and its misregulation is implicated in congenital malformations. Here, we investigated molecular mechanisms pertaining to NC-related symptoms in Bohring-Opitz syndrome (BOS),
Externí odkaz:
https://doaj.org/article/47588cb4f1c143b688f381ede1d9194b
Autor:
Thomas B. Hildebrandt, Robert Hermes, Silvia Colleoni, Sebastian Diecke, Susanne Holtze, Marilyn B. Renfree, Jan Stejskal, Katsuhiko Hayashi, Micha Drukker, Pasqualino Loi, Frank Göritz, Giovanna Lazzari, Cesare Galli
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
The Southern (SWR) and Northern (NWR) are two subspecies of the White Rhinoceros with the NWR being almost extinct. Here, using assisted reproduction technology, the authors produce and cryopreserve SWR purebred and NWR-SWR hybrid embryos developed t
Externí odkaz:
https://doaj.org/article/acb398fe07bb451baa38cde6750dd7ae
Autor:
Adam C. O’Neill, Christina Kyrousi, Johannes Klaus, Richard J. Leventer, Edwin P. Kirk, Andrew Fry, Daniela T. Pilz, Tim Morgan, Zandra A. Jenkins, Micha Drukker, Samuel F. Berkovic, Ingrid E. Scheffer, Renzo Guerrini, David M. Markie, Magdalena Götz, Silvia Cappello, Stephen P. Robertson
Publikováno v:
Cell Reports, Vol 25, Iss 10, Pp 2729-2741.e6 (2018)
Summary: The mammalian neocortex has undergone remarkable changes through evolution. A consequence of such rapid evolutionary events could be a trade-off that has rendered the brain susceptible to certain neurodevelopmental and neuropsychiatric condi
Externí odkaz:
https://doaj.org/article/d95a7e66dd6f4400b94ec2e97ad2e7b3
Autor:
Adam C. O’Neill, Christina Kyrousi, Melanie Einsiedler, Ingo Burtscher, Micha Drukker, David M. Markie, Edwin P. Kirk, Magdalena Götz, Stephen P. Robertson, Silvia Cappello
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Disorders of neuronal mispositioning during brain development are phenotypically heterogeneous and their genetic causes remain largely unknown. Here, we report biallelic variants in a Hippo signaling factor—MOB2—in a patient with one such disorde
Externí odkaz:
https://doaj.org/article/55a80b0d7f3942dc8de72836ea5c1499