Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Michał Taube"'
Autor:
Maciej Gielnik, Michał Taube, Lilia Zhukova, Igor Zhukov, Sebastian K. T. S. Wärmländer, Željko Svedružić, Wojciech M. Kwiatek, Astrid Gräslund, Maciej Kozak
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The cellular prion protein (PrPC) is a mainly α-helical 208-residue protein located in the pre- and postsynaptic membranes. For unknown reasons, PrPC can undergo a structural transition into a toxic, β-sheet rich scrapie isoform (PrPSc) th
Externí odkaz:
https://doaj.org/article/2fe3416e0e5f40d4a4f38ea7f65014b5
A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity
Autor:
Atilio Reyes Romero, Serjey Lunev, Grzegorz M. Popowicz, Vito Calderone, Matteo Gentili, Michael Sattler, Jacek Plewka, Michał Taube, Maciej Kozak, Tad A. Holak, Alexander S. S. Dömling, Matthew R. Groves
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Romero et al. perform NMR-based screening of 1500 fragments to identify fragments that bind at the oligomeric interface of malate dehydrogenase (MDH). Their study indicates an allosteric mechanism impacting enzymatic activity, paving the way for deve
Externí odkaz:
https://doaj.org/article/f14c722416964fa8b99c79a63335b872
Autor:
Dominika Bystranowska, Anna Skorupska, Katarzyna Sołtys, Michał Padjasek, Artur Krężel, Andrzej Żak, Magdalena Kaus-Drobek, Michał Taube, Maciej Kozak, Andrzej Ożyhar
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 4300-4318 (2021)
Nucleobindin-2 (Nucb2) is a protein that has been suggested to play roles in a variety of biological processes. Nucb2 contains two Ca2+/Mg2+-binding EF-hand domains separated by an acidic amino acid residue-rich region and a leucine zipper. All of th
Externí odkaz:
https://doaj.org/article/ea72a921a0104061a2d4cbcf278b3a03
Autor:
Marta Kolonko, Dominika Bystranowska, Michał Taube, Maciej Kozak, Mark Bostock, Grzegorz Popowicz, Andrzej Ożyhar, Beata Greb-Markiewicz
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-22 (2020)
Abstract The Drosophila melanogaster Germ cell-expressed protein (GCE) is a paralog of the juvenile hormone (JH) receptor - Methoprene tolerant protein (MET). Both proteins mediate JH function, preventing precocious differentiation during D. melanoga
Externí odkaz:
https://doaj.org/article/8d8ba55493a94d818ba65dbb760cc563
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13441 (2022)
Human cystatin C (HCC), an amyloidogenic protein, forms dimers and higher oligomers (trimers, tetramers and donut like large oligomers) via a domain-swapping mechanism. The aim of this study was the characterization of the HCC oligomeric states obser
Externí odkaz:
https://doaj.org/article/55194186f37a44eebfc68968360d1128
Autor:
Magdalena Chrabąszczewska, Maria Winiewska-Szajewska, Natalia Ostrowska, Elżbieta Bojarska, Janusz Stępiński, Łukasz Mancewicz, Maciej Łukaszewicz, Joanna Trylska, Michał Taube, Maciej Kozak, Edward Darżynkiewicz, Renata Grzela
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 10929 (2021)
Nudt16 is a member of the NUDIX family of hydrolases that show specificity towards substrates consisting of a nucleoside diphosphate linked to another moiety X. Several substrates for hNudt16 and various possible biological functions have been report
Externí odkaz:
https://doaj.org/article/9d81917284e84e71814b0beb925f2024
Autor:
Roksana Markiewicz, Adam Klimaszyk, Marcin Jarek, Michał Taube, Patryk Florczak, Marek Kempka, Zbigniew Fojud, Stefan Jurga
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5935 (2021)
The application of ionic liquids (ILs) has grown enormously, from their use as simple solvents, catalysts, media in separation science, or electrolytes to that as task-specific, tunable molecular machines with appropriate properties. A thorough under
Externí odkaz:
https://doaj.org/article/b9475f6e65964417aef494928cedcd89
Autor:
Michał Marcinkowski, Tomaš Pilžys, Damian Garbicz, Jan Piwowarski, Damian Mielecki, Grzegorz Nowaczyk, Michał Taube, Maciej Gielnik, Maciej Kozak, Maria Winiewska-Szajewska, Ewa Szołajska, Janusz Dębski, Agnieszka M. Maciejewska, Kaja Przygońska, Karolina Ferenc, Elżbieta Grzesiuk, Jarosław Poznański
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4512 (2021)
The FTO protein is involved in a wide range of physiological processes, including adipogenesis and osteogenesis. This two-domain protein belongs to the AlkB family of 2-oxoglutarate (2-OG)- and Fe(II)-dependent dioxygenases, displaying N6-methyladeno
Externí odkaz:
https://doaj.org/article/2b261959dc6147a9b636ed04b983367f
Autor:
Jakub Dolata, Michał Taube, Mateusz Bajczyk, Artur Jarmolowski, Zofia Szweykowska-Kulinska, Dawid Bielewicz
Publikováno v:
Frontiers in Plant Science, Vol 9 (2018)
MicroRNAs are small molecules (∼21 nucleotides long) that are key regulators of gene expression. They originate from long stem–loop RNAs as a product of cleavage by a protein complex called Microprocessor. The core components of the plant Micropr
Externí odkaz:
https://doaj.org/article/1b509825e244414d83636221a3147145
Autor:
Marta Kolonko, Katarzyna Ożga, Rafał Hołubowicz, Michał Taube, Maciej Kozak, Andrzej Ożyhar, Beata Greb-Markiewicz
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162950 (2016)
Methoprene tolerant protein (Met) has recently been confirmed as the long-sought juvenile hormone (JH) receptor. This protein plays a significant role in the cross-talk of the 20-hydroxyecdysone (20E) and JH signalling pathways, which are important f
Externí odkaz:
https://doaj.org/article/4623b73d2a3b4b4f9160b541166b3456