Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Michał Kosno"'
Autor:
Tomasz Laskowski, Michał Kosno, Witold Andrałojć, Joanna E. Frackowiak, Julia Borzyszkowska-Bukowska, Paweł Szczeblewski, Nikola Radoń, Maria Świerżewska, Anna Woźny, Ewa Paluszkiewicz, Zofia Mazerska
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Members of a novel class of anticancer compounds, exhibiting high antitumor activity, i.e. the unsymmetrical bisacridines (UAs), consist of two heteroaromatic ring systems. One of the ring systems is an imidazoacridinone moiety, with the ske
Externí odkaz:
https://doaj.org/article/b86a65dc604446ca99c39fb296840082
Autor:
Paweł Szczeblewski, Mateusz Wróblewski, Julia Borzyszkowska-Bukowska, Tetiana Bairamova, Justyna Górska, Tomasz Laskowski, Anna Samulewicz, Michał Kosno, Łukasz Sobiech, Justyna Teresa Polit, Wirginia Kukula-Koch
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Β-asarone is a phenylpropane derivative present in the rhizomes of Acorus calamus, that was proved to exhibit toxic effects in humans. Because of its presence the whole plant that is commonly used in traditional medicine for its sedative, a
Externí odkaz:
https://doaj.org/article/5ef5a62ccf1046d6a3abfae787854d66
Autor:
Agnieszka Potęga, Dominika Rafalska, Dawid Kazimierczyk, Michał Kosno, Aleksandra Pawłowicz, Witold Andrałojć, Ewa Paluszkiewicz, Tomasz Laskowski
Publikováno v:
Molecules, Vol 28, Iss 19, p 6812 (2023)
This work is the next step in studying the interplay between C-2028 (anticancer-active unsymmetrical bisacridine developed in our group) and the glutathione S-transferase/glutathione (GST/GSH) system. Here, we analyzed the concentration- and pH-depen
Externí odkaz:
https://doaj.org/article/495970c7078f4f1ebd453da375956528
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 11, Iss 6, Pp 791-798 (2021)
Unsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. A significant route of phase II drug metabolism is conjugation with glutathione (GSH), which can be non-enzymatic and/or catalyzed by GSH-dependent enzymes. T
Externí odkaz:
https://doaj.org/article/af970ca62e2d4b51a1bbec8871eb1181
Autor:
Michał Kosno, Tomasz Laskowski, Joanna E. Frackowiak, Agnieszka Potęga, Agnieszka Kurdyn, Witold Andrałojć, Julia Borzyszkowska-Bukowska, Katarzyna Szwarc-Karabyka, Zofia Mazerska
Publikováno v:
Molecules, Vol 27, Iss 13, p 3995 (2022)
Unsymmetrical bisacridines (UAs) represent a novel class of anticancer agents previously synthesized by our group. Our recent studies have demonstrated their high antitumor potential against multiple cancer cell lines and human tumor xenografts in nu
Externí odkaz:
https://doaj.org/article/a1af03541ea746f7ab40cf5703d38fc1
Autor:
Anna Mieszkowska, Anna M. Nowicka, Agata Kowalczyk, Agnieszka Potęga, Monika Pawłowska, Michał Kosno, Ewa Augustin, Zofia Mazerska
Publikováno v:
Pharmaceuticals, Vol 14, Iss 4, p 317 (2021)
New unsymmetrical bisacridines (UAs) demonstrated high activity not only against a set of tumor cell lines but also against human tumor xenografts in nude mice. Representative UA compounds, named C-2028, C-2045 and C-2053, were characterized in respe
Externí odkaz:
https://doaj.org/article/33875ddea39b432b90bf1e1d31950aa1
Autor:
Michał Kosno, Tomasz Laskowski, Joanna E. Frackowiak, Agnieszka Potęga, Agnieszka Kurdyn, Witold Andrałojć, Julia Borzyszkowska-Bukowska, Katarzyna Szwarc-Karabyka, Zofia Mazerska
Unsymmetrical bisacridines (UAs), which represent a novel group of anticancer agents, were previously synthesized by our group. Our recent studies have shown high antitumor potential of UAs against multiple cancer cell lines and human tumor xenograft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40dbbb5292b0b59b3a5232d36ad49508
https://doi.org/10.21203/rs.3.rs-1579934/v1
https://doi.org/10.21203/rs.3.rs-1579934/v1
Publikováno v:
Journal of Pharmaceutical Analysis
Journal of Pharmaceutical Analysis, Vol 11, Iss 6, Pp 791-798 (2021)
Journal of Pharmaceutical Analysis, Vol 11, Iss 6, Pp 791-798 (2021)
Unsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. A significant route of phase II drug metabolism is conjugation with glutathione (GSH), which can be non-enzymatic and/or catalyzed by GSH-dependent enzymes. T
Autor:
Michał Kosno, Włodzisław Kuliński
Publikováno v:
Wiadomosci lekarskie (Warsaw, Poland : 1960). 74(3 cz 1)
Objective The aim: To assess the quality of life in women after mastectomy. Patients and methods Materials and methods: The study included 25 women after mastectomy. The patients were aged 31 to over 50 years and were members of a breast cancer suppo
Autor:
Monika Pawłowska, Ewa Augustin, Anna M. Nowicka, Anna Mieszkowska, Michał Kosno, Agnieszka Potęga, Agata Kowalczyk, Zofia Mazerska
Publikováno v:
Pharmaceuticals
Volume 14
Issue 4
Pharmaceuticals, Vol 14, Iss 317, p 317 (2021)
Volume 14
Issue 4
Pharmaceuticals, Vol 14, Iss 317, p 317 (2021)
New unsymmetrical bisacridines (UAs) demonstrated high activity not only against a set of tumor cell lines but also against human tumor xenografts in nude mice. Representative UA compounds, named C-2028, C-2045 and C-2053, were characterized in respe