Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Michał, Zimecki"'
Autor:
Krzysztof Kaczmarek, Jolanta Artym, Joanna Bojarska, Barbara Pacholczyk-Sienicka, Joanna Waśko, Ingrid Jelemenska, Wojciech M. Wolf, Martin Breza, Michał Zimecki
Publikováno v:
Pharmaceutics, Vol 16, Iss 8, p 1106 (2024)
The anti-inflammatory, antiviral, and anti-cancer properties, as well as the mechanism of action of cyclo-[Pro-Pro-β3-HoPhe-Phe-] tetrapeptide (denoted as 4B8M), were recently described. The aim of this work was to synthesize and evaluate the immuno
Externí odkaz:
https://doaj.org/article/7fad97f9e46f4960810bada3b0d223b0
Autor:
Michał Zimecki, Jolanta Artym, Maja Kocięba, Ewa Zaczyńska, Angelika Sysak, Marianna Szczypka, Magdalena Lis, Aleksandra Pawlak, Bożena Obmińska-Mrukowicz, Katarzyna Kaleta-Kuratewicz, Aleksandra Zambrowicz, Łukasz Bobak
Publikováno v:
Molecules, Vol 29, Iss 14, p 3254 (2024)
Yolkin, an egg yolk immunoregulatory protein, stimulates the humoral but inhibits the cellular immune response in adult mice. The aim of this investigation was to evaluate the effects of yolkin administration on the immune response using a model of j
Externí odkaz:
https://doaj.org/article/153321340a8749938f69cff6c92179f3
Autor:
Jolanta Artym, Michał Zimecki
Publikováno v:
Biomedicines, Vol 11, Iss 4, p 1015 (2023)
In this article, we review the benefits of applying bovine colostrum (BC) and lactoferrin (LF) in animal models and clinical trials that include corticosteroid application and psychic stress, treatment with non-steroid anti-inflammatory drugs (NSAIDs
Externí odkaz:
https://doaj.org/article/2d66deceae53405fbca3e7faf75628d1
Autor:
Jolanta Artym, Michał Zimecki
Publikováno v:
Biomedicines, Vol 11, Iss 1, p 114 (2023)
In this article, we review the benefits of application of colostrum and colostrum-derived proteins in animal models and clinical trials that include chemotherapy with antimetabolic drugs, radiotherapy and surgical interventions. A majority of the rep
Externí odkaz:
https://doaj.org/article/6be7dea491c7429b927a56745aa3a5f0
Publikováno v:
Molecules, Vol 27, Iss 11, p 3552 (2022)
The core of Cyclolinopeptide A (CLA, cyclo(LIILVPPFF)), responsible for its high immunosuppressive activity, contains a Pro-Pro-Phe-Phe sequence. A newly synthesized cyclic tetrapeptide, cyclo(Pro-Pro-β3-HoPhe-Phe) (denoted as 4B8M) bearing the acti
Externí odkaz:
https://doaj.org/article/203bdc5400f64daea9a1c3fe29da60b7
Autor:
Jolanta Artym, Michał Zimecki
Publikováno v:
Biomedicines, Vol 9, Iss 12, p 1940 (2021)
Women’s intimate health depends on several factors, such as age, diet, coexisting metabolic disorders, hormonal equilibrium, sexual activity, drug intake, contraception, surgery, and personal hygiene. These factors may affect the homeostasis of the
Externí odkaz:
https://doaj.org/article/17b8a38b65634ce0b0345a558f063450
Publikováno v:
Biomedicines, Vol 9, Iss 8, p 898 (2021)
Pregnancy is a physiological state that demands higher level of nutrients, including vitamins and minerals, for the growth and maintenance of the fetus. Iron deficiency is a part of most common diet deficiencies in pregnancy and has high clinical sig
Externí odkaz:
https://doaj.org/article/56e0aa97a40c4e179567df850f04660f
Autor:
Marcin Mączyński, Andrzej Regiec, Aleksandra Sochacka-Ćwikła, Iwona Kochanowska, Maja Kocięba, Ewa Zaczyńska, Jolanta Artym, Wojciech Kałas, Michał Zimecki
Publikováno v:
Pharmaceuticals, Vol 14, Iss 5, p 468 (2021)
Previous studies demonstrated strong anti-inflammatory properties of isoxazolo[5,4-e]-1,2,4-triazepine (RM33) in vivo. The aim of this investigation was to describe synthesis, determine physicochemical characteristics, evaluate biological activities
Externí odkaz:
https://doaj.org/article/a55629886c2a497e927fd7abc05fb28f
Autor:
Michał Zimecki, Krzysztof Kaczmarek
Publikováno v:
Molecules, Vol 26, Iss 9, p 2538 (2021)
The consequences of manipulations in structure and amino acid composition of native cyclolinopeptide A (CLA) from linen seeds, and its linear precursor on their biological activities and mechanisms of action, are reviewed. The modifications included
Externí odkaz:
https://doaj.org/article/e0ba02ab2aa24d9eb541c0ee9ef9c0af
Autor:
Michał Zimecki, Jolanta Artym, Wojciech Kałas, Leon Strządała, Katarzyna Kaleta-Kuratewicz, Jan Kuryszko, Andrzej Kaszuba, Krzysztof Kaczmarek, Janusz Zabrocki
Publikováno v:
Pharmaceutics, Vol 12, Iss 11, p 1030 (2020)
A cyclic tetrapeptide Pro-Pro-Pheβ3ho-Phe (4B8M) was tested for immunosuppressive activity and potential therapeutic utility in several in vitro and in vivo mouse and human models. The tetrapeptide was less toxic for mouse splenocytes in comparison
Externí odkaz:
https://doaj.org/article/bcd244c131904481bce0f7c27e5622b3