Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Michał, Szczyrek"'
Autor:
Anna Grenda, Ewelina Iwan, Izabela Chmielewska, Paweł Krawczyk, Aleksandra Giza, Arkadiusz Bomba, Małgorzata Frąk, Anna Rolska, Michał Szczyrek, Robert Kieszko, Tomasz Kucharczyk, Bożena Jarosz, Dariusz Wasyl, Janusz Milanowski
Publikováno v:
AMB Express, Vol 12, Iss 1, Pp 1-7 (2022)
Key points Composition of the microbiome can influence patients response to immunotherapy Response to immunotherapy of NSCLC patients is associated with the presence of Akkermansiaceae in the gut Akkermansia could be used as a predictor for patient t
Externí odkaz:
https://doaj.org/article/18beb8b224e645819cdd58155b18d256
Autor:
Aneta Szudy-Szczyrek, Sylwia Chocholska, Oliwia Bachanek-Mitura, Olga Czabak, Radosław Mlak, Michał Szczyrek, Justyna Muzyka-Kasietczuk, Marek Hus
Publikováno v:
Annals of Agricultural and Environmental Medicine, Vol 29, Iss 1, Pp 103-109 (2021)
Introduction and objective Multiple myeloma (MM) is an incurable condition with variable clinical course. The study included a group of patients with especially poor-prognosis, individuals with relapsed/refractory multiple myeloma (RRMM) and specific
Externí odkaz:
https://doaj.org/article/7a8307a3e68d4f7999f18813e8ff6869
Autor:
Aneta Szudy-Szczyrek, Radosław Mlak, Marcin Mazurek, Tomasz Krajka, Sylwia Chocholska, Paulina Bitkowska, Marta Jutrzenka, Michał Szczyrek, Iwona Homa-Mlak, Andrzej Krajka, Teresa Małecka-Massalska, Marek Hus
Publikováno v:
Cells, Vol 12, Iss 7, p 1029 (2023)
Background: The KIAA1524 gene encodes an oncoprotein, CIP2A, which inhibits the phosphorylation of the Akt kinase B, stabilizes the c-Myc protein, and, through that, promotes cancerogenesis. An increase in CIP2A expression has been observed in numero
Externí odkaz:
https://doaj.org/article/81ef62186586406e9184cf01bbe6a434
Autor:
Anna Grenda, Justyna Błach, Michał Szczyrek, Paweł Krawczyk, Marcin Nicoś, Barbara Kuźnar Kamińska, Monika Jakimiec, Grażyna Balicka, Izabela Chmielewska, Halina Batura‐Gabryel, Marek Sawicki, Janusz Milanowski
Publikováno v:
Cancer Medicine, Vol 9, Iss 2, Pp 605-614 (2020)
Abstract Background Topoisomerase 2‐alpha (TOP2A) is an enzyme that controls topologic changes in DNA during transcription and replication. ERCC1 is an enzyme that takes part in DNA repair processes. The purpose of this study was to assess the pred
Externí odkaz:
https://doaj.org/article/58770bce40d5492099a86eba3484740c
Autor:
Paweł Krawczyk, Luiza Grzycka-Kowalczyk, Justyna Błach, Katarzyna Reszka, Izabela Chmielewska, Robert Kieszko, Magdalena Wójcik-Superczyńska, Michał Szczyrek, Tomasz Jankowski, Janusz Milanowski
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0267846 (2022)
Osimertnib is still widely used in the treatment of NSCLC patients who have previously received erlotinib, gefitinib or afatinib and have developed resistance to these drugs mediated by the T790M mutation in exon 20 of EGFR gene. We assessed the resu
Externí odkaz:
https://doaj.org/article/c17aa854aa3f4957a5cd8869b84a7ed0
Autor:
Katarzyna Stefańska, Monika Jakimiec-Komisarczyk, Paulina Terlecka, Marcelina Makuch, Joanna Jakimiec, Magdalena Igras-Kołdyj, Michał Szczyrek, Robert Kieszko, Agnieszka Zwolak, Janusz Milanowski, Robert Jan Łuczyk
Publikováno v:
Journal of Education, Health and Sport, Vol 9, Iss 4, Pp 256-264 (2019)
Cystic fibrosis (CF) is classified as metabolic and multisystem disease with autosomal recessive inheritance caused by mutations in the gene located on chromosome 7 encoding cystic fibrosis transmembrane conductance regulator (CFTR) protein. CFTR is
Externí odkaz:
https://doaj.org/article/008399514bbc4dcebb35de359c1f8a44
Autor:
Anna Grenda, Paweł Krawczyk, Justyna Błach, Izabela Chmielewska, Tomasz Kubiatowski, Stanisław Kieszko, Kamila Wojas-Krawczyk, Tomasz Kucharczyk, Bożena Jarosz, Iwona Paśnik, Małgorzata Borowiec-Bar, Małgorzata Frąk, Robert Kieszko, Michał Szczyrek, Katarzyna Reszka, Kinga Krukowska, Agnieszka Kolak, Sławomir Mańdziuk, Dariusz Kowalski, Marek Sawicki, Daria Świniuch, Elżbieta Starosławska, Rodryg Ramlau, Justyna Szumiło, Maciej Krzakowski, Janusz Milanowski
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
IntroductionExpression of PD-L1 protein on tumor cells, which is so far the only validated predictive factor for immunotherapy, is regulated by epigenetic and genetic factors. Among the most important ones that regulate gene expression are microRNAs.
Externí odkaz:
https://doaj.org/article/c993130ac66d46a888f3466869076bb7
Autor:
Izabela Chmielewska, Marta Dudzińska, Michał Szczyrek, Joanna Świrska, Kamila Wojas-Krawczyk, Agnieszka Zwolak
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257484 (2021)
The aim of the study was to assess the occurrence and nature of immune-related endocrine adverse events (irAEs) among patients with non-small-cell lung cancer (NSCLC) treated with nivolumab.MethodsThe study group included 35 patients (15 women, 20 me
Externí odkaz:
https://doaj.org/article/957a972f916045bdb2d357d2b90ec215
Autor:
Michał Szczyrek, Radosław Mlak, Aneta Szudy-Szczyrek, Kamila Wojas-Krawczyk, Karolina Kędziora, Janusz Milanowski
Publikováno v:
Cells, Vol 11, Iss 6, p 956 (2022)
Non-small cell lung cancer (NSCLC) comprises about 85% of all lung cancers. Currently, NSCLC therapy is based on the analysis of specific predictors, whose presence qualifies patients for appropriate treatment. Baculoviral inhibitor of apoptosis repe
Externí odkaz:
https://doaj.org/article/ee1ee807eccf4ccca28a0b63ee169e4b
Autor:
Aneta Szudy-Szczyrek, Radosław Mlak, Michał Mielnik, Marcin Mazurek, Sylwia Chocholska, Martyna Podgajna, Michał Szczyrek, Iwona Homa-Mlak, Teresa Małecka-Massalska, Marek Hus
Publikováno v:
Cells, Vol 11, Iss 4, p 752 (2022)
MiRNA-8074 is a molecule with the potential to regulate the expression of key genes related to the pathogenesis of multiple myeloma (MM), i.e., TP53, MYC, MAPK1, and KIAA. We analyzed the predictive and prognostic value of miRNA-8074 expression in MM
Externí odkaz:
https://doaj.org/article/814cd740b9ec46e984f4e59cac77b442