Výsledky vyhledávání - "Michaël Broux"

Akademický článek

Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters

Autor: Noortje van Gils, Han J.M.P. Verhagen, Michaël Broux, Tania Martiáñez, Fedor Denkers, Eline Vermue, Arjo Rutten, Tamás Csikós, Sofie Demeyer, Meryem Çil, Marjon Al, Jan Cools, Jeroen J.W.M. Janssen, Gert J. Ossenkoppele, Renee X. Menezes, Linda Smit

Publikováno v: iScience, Vol 25, Iss 9, Pp 105013- (2022)

Summary: Although chemotherapy induces complete remission in the majority of acute myeloid leukemia (AML) patients, many face a relapse. This relapse is caused by survival of chemotherapy-resistant leukemia (stem) cells (measurable residual disease;

Externí odkaz: https://doaj.org/article/84ab3dd633704ce3b8af11a7a4647841

Zobrazit plný text záznamu

Akademický článek

The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts

Publikováno v: Cell Reports, Vol 12, Iss 6, Pp 992-1005 (2015)

Several questions about the role of the oxygen sensor prolyl-hydroxylase 2 (PHD2) in cancer have not been addressed. First, the role of PHD2 in metastasis has not been studied in a spontaneous tumor model. Here, we show that global PHD2 haplodeficien

Externí odkaz: https://doaj.org/article/84a2f84782c44a938ff33527b7a39ea2

Zobrazit plný text záznamu

Akademický článek

Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia

Autor: Carmen Vicente, Claire Schwab, Michaël Broux, Ellen Geerdens, Sandrine Degryse, Sofie Demeyer, Idoya Lahortiga, Alannah Elliott, Lucy Chilton, Roberta La Starza, Cristina Mecucci, Peter Vandenberghe, Nicholas Goulden, Ajay Vora, Anthony V. Moorman, Jean Soulier, Christine J. Harrison, Emmanuelle Clappier, Jan Cools

Publikováno v: Haematologica, Vol 100, Iss 10 (2015)

T-cell acute lymphoblastic leukemia is caused by the accumulation of multiple oncogenic lesions, including chromosomal rearrangements and mutations. To determine the frequency and co-occurrence of mutations in T-cell acute lymphoblastic leukemia, we

Externí odkaz: https://doaj.org/article/a2cd13866e9149328895ca16af136aff

Zobrazit plný text záznamu

Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified

Autor: Daan Dierickx, Philippe Gaulard, Carlos Graux, Koen Debackere, Laurence de Leval, Nicole Mentens, Jan Cools, Lucienne Michaux, Kris Jacobs, Thomas Tousseyn, Sofie Demeyer, Olga Gielen, Michaël Broux, Iwona Wlodarska, Marlies Vanden Bempt, Lukas Marcelis, Gregor Verhoef

Publikováno v: Nature communications, vol. 12, no. 1, pp. 3705
Nature communications, Vol. 12, no.1, p. 3705 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications

Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of non-Hodgkin lymphomas with poor prognosis. Up to 30% of PTCL lack distinctive features and are classified as PTCL, not otherwise specified (PTCL-NOS). To further improve our understanding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::133ce4ef8eab96b32fc1be9ac3896731
https://doi.org/10.1038/s41467-021-24037-4

Zobrazit plný text záznamu

Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia

Autor: Charles E. de Bock, Sofie Demeyer, Ellen Geerdens, Cristina Prieto, Olga Gielen, Nicole Mentens, Jan Cools, Kris Jacobs, Roel Vandepoel, Inge Lodewijckx, Michaël Broux, Llucia Alberti-Servera, Marlies Vanden Bempt, Carmen Vicente

The polycomb repressive complex 2, with core components EZH2, SUZ12, and EED, is responsible for writing histone 3 lysine 27 trimethylation histone marks associated with gene repression. Analysis of sequence data from 419 T-cell acute lymphoblastic l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea68fdb553688e421bd5b43fd918d8a
https://lirias.kuleuven.be/handle/123456789/645192

Zobrazit plný text záznamu

Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia

Autor: Sofie Demeyer, Jean-Pierre Bourquin, Simon Bornschein, Beat Bornhauser, Nicole Mentens, Jan Cools, Enrico Radaelli, Charles E. de Bock, Ellen Geerdens, Michaël Broux, Jolien De Bie, Andreas E. Kulozik, Jules P.P. Meijerink, Marlies Vanden Bempt, Roel Vandepoel

Publikováno v: Cancer Cell

Summary The NUP214-ABL1 fusion is a constitutively activated tyrosine kinase that is significantly associated with overexpression of the TLX1 and TLX3 transcription factors in T cell acute lymphoblastic leukemia (T-ALL). Here we show that NUP214-ABL1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254bba163caeee536b9a03eaaf3aefa2
https://lirias.kuleuven.be/handle/123456789/628593

Zobrazit plný text záznamu

Single-cell sequencing reveals the origin and the order of mutation acquisition in T-cell acute lymphoblastic leukemia

Autor: Lucienne Michaux, Ellen Geerdens, Jolien De Bie, Nancy Boeckx, Kim De Keersmaecker, Heidi Segers, Jan Cools, Sofie Demeyer, Peter Vandenberghe, Llucia Alberti-Servera, Michaël Broux, Anne Uyttebroeck, Thierry Voet

Publikováno v: Leukemia

Next-generation sequencing has provided a detailed overview of the various genomic lesions implicated in the pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL). Typically, 10-20 protein-altering lesions are found in T-ALL cells at diagnosis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045c6aa6e8f8ebb414a5e25df2ec60c1
https://pubmed.ncbi.nlm.nih.gov/29740158

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání