A Sub-Micromolar MraYAA Inhibitor with an Aminoribosyl Uridine Structure and a (S,S)-Tartaric Diamide: Synthesis, Biological Evaluation and Molecular Modeling

Autor: Martin Oliver, Laurent Le Corre, Mélanie Poinsot, Michaël Bosco, Hongwei Wan, Ana Amoroso, Bernard Joris, Ahmed Bouhss, Sandrine Calvet-Vitale, Christine Gravier-Pelletier

Publikováno v: Molecules, Vol 27, Iss 6, p 1769 (2022)

New inhibitors of the bacterial tranferase MraY are described. Their structure is based on an aminoribosyl uridine scaffold, which is known to be important for the biological activity of natural MraY inhibitors. A decyl alkyl chain was introduced ont

Externí odkaz: https://doaj.org/article/21f58ea949fc468d8947943dab983c17

Brefeldin A promotes the appearance of oligosaccharyl phosphates derived from Glc3Man9GlcNAc2-PP-dolichol within the endomembrane system of HepG2 cells

Autor: Ahmad Massarweh, Michaël Bosco, Soria Iatmanen-Harbi, Clarice Tessier, Laura Amana, Patricia Busca, Isabelle Chantret, Christine Gravier-Pelletier, Stuart E.H. Moore

Publikováno v: Journal of Lipid Research, Vol 57, Iss 8, Pp 1477-1491 (2016)

We reported an oligosaccharide diphosphodolichol (DLO) diphosphatase (DLODP) that generates dolichyl-phosphate and oligosaccharyl phosphates (OSPs) from DLO in vitro. This enzyme could underlie cytoplasmic OSP generation and promote dolichyl-phosphat

Externí odkaz: https://doaj.org/article/9a77360137a44117ae0fe955a561a1d6

Synthetic Route to Glycosyl β-1C-(phosphino)-phosphonates as Unprecedented Stable Glycosyl Diphosphate Analogs and Their Preliminary Biological Evaluation

Autor: Michaël Bosco, Su-Jin Paik, Patricia Busca, Stuart E. H. Moore, Christine Gravier-Pelletier

Publikováno v: Molecules, Vol 25, Iss 21, p 4969 (2020)

The synthesis of glycosyl-β-1C-(phosphino)-phosphonates is a challenge since it has not yet been described. In this paper, we report an innovative synthetic method for their preparation from Glc-, Man-, and GlcNAc- lactone derivatives. The proposed

Externí odkaz: https://doaj.org/article/3f428dd9cbb84f0eb275631fe84b672e

Gd3+ Complexes Conjugated to Cyclodextrins: Hydroxyl Functions Influence the Relaxation Properties

Autor: Célia S. Bonnet, Éva Tóth, François Estour, Anais Biscotti, Berthe-Sandra Sembo-Backonly, Agnès Pallier, Michaël Bosco, Cécile Barbot, Géraldine Gouhier, Sébastien Balieu

Publikováno v: Processes
Volume 9
Issue 2
Processes, Vol 9, Iss 269, p 269 (2021)
Processes, MDPI, 2021, 9 (2), pp.269. ⟨10.3390/pr9020269⟩

In the search for improvement in the properties of gadolinium-based contrast agents, cyclodextrins (CDs) are interesting hydrophilic scaffolds with high molecular weight. The impact of the hydrophilicity of these systems on the MRI efficacy has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::314b4906bf33e458317903ca4ff88796

Demonstration of an oligosaccharide-diphosphodolichol diphosphatase activity whose subcellular localization is different than those of dolichyl-phosphate-dependent enzymes of the dolichol cycle

Autor: Stuart E.H. Moore, Soria Iatmanen-Harbi, Michaël Bosco, Christine Gravier-Pelletier, Nicolas Auberger, Isabelle Chantret, Ahmad Massarweh, Patricia Busca, Clarice Tessier

Publikováno v: Journal of Lipid Research, Vol 57, Iss 6, Pp 1029-1042 (2016)
Journal of Lipid Research
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2016, 57 (6), pp.1029-1042. ⟨10.1194/jlr.M067330⟩

Oligosaccharyl phosphates (OSPs) are hydrolyzed from oligosaccharide-diphosphodolichol (DLO) during protein N-glycosylation by an uncharacterized process. An OSP-generating activity has been reported in vitro, and here we asked if its biochemical cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11fc721d924429a097f727024763a5cf
http://www.sciencedirect.com/science/article/pii/S0022227520351804