Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Michèle Willson"'
Autor:
Michele Willson, Tama Leaver
This book is available as open access through the Bloomsbury Open Access programme and is available on www.bloomsburycollections.com.Social, casual and mobile games, played on devices such as smartphones, tablets, or PCs and accessed through online s
This volume focuses on very young children's (aged 0-8) rights in a digital world. It gathers current research from around the globe that focuses on young children's rights as agental citizens to the provision of and participation in digital devices
Autor:
Laurent Azema, Emmanuel Tetaud, Dominique Cottem, Michèle Willson, Frederik Opperdoes, Isabelle Alric, Jacques Périé, Michael P. Barrett, Frédéric Bringaud, Casimir Blonski, Samantha Claustre, Théo Baltz
Publikováno v:
Biochemical Pharmacology. 67:459-467
Glucose metabolism is essential for survival of bloodstream form Trypanosoma brucei subspecies which cause human African trypanosomiasis (sleeping sickness). Hexose analogues may represent good compounds to inhibit glucose metabolism in these cells.
Autor:
Marcelo Santos Castilho, Colette Denier, Sylvain Ladame, Michèle Willson, Glaucius Oliva, Jacques Périé, Véronique Hannaert, Carlos H T P Silva
Publikováno v:
European Journal of Biochemistry. 270:4574-4586
We report here the first crystal structure of a stable isosteric analogue of 1,3-bisphospho-d-glyceric acid (1,3-BPGA) bound to the catalytic domain of Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH) in which the two ph
Autor:
Jacques Perie, Paul A.M. Michels, Michèle Willson, Claudia Lopez, Faouzi Lakhdar-Ghazal, Nathalie Chevalier, Colette Denier, Andrée Lougare, Samantha Claustre
Publikováno v:
Biochemistry. 41:10183-10193
This work deals with the phosphofructokinase enzyme (PFK) of the parasite Trypanosoma brucei. Inhibitors which are analogues of fructose-6-phosphate (F6P) derived from 2,5-anhydromannitol and therefore blocked in a closed conformation, both nonphosph
Autor:
Frederik Opperdoes, Michèle Willson, Véronique Hannaert, Yves Henri Sanejouand, Jacques Périé
Publikováno v:
Chemistry & Biology. 9:839-847
For Trypanosoma brucei, a parasite responsible for African sleeping sickness, carbohydrate metabolism is the only source of ATP, and glycolytic enzymes are localized within membrane-bound organelles called glycosomes. Hexokinase, the first enzyme of
Autor:
Christophe L. M. J. Verlinde, Paul A.M. Michels, Véronique Hannaert, Michael H. Gelb, Michèle Willson, Fred R. Opperdoes, Jacques Périé, Linda A. Fothergill-Gilmore, Wim G. J. Hol, Casimir Blonski
Publikováno v:
Drug Resistance Updates. 4:50-65
Glycolysis is perceived as a promising target for new drugs against parasitic trypanosomatid protozoa because this pathway plays an essential role in their ATP supply. Trypanosomatid glycolysis is unique in that it is compartmentalized, and many of i
Autor:
Jacques Périé, Michèle Willson
Publikováno v:
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 55:911-917
Glucosamine analogues are inhibitors of yeast hexokinase (HK); kinetic analysis with respect to glucose and ATP suggests a pseudo-substrate behaviour for these compounds. However, a spectroscopy study by 31P NMR indicates that they are not phosphoryl
Publikováno v:
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 54:367-373
The infrared (FTIR) spectroscopy study of several complexes of yeast hexokinase with substrates and inhibitors allows the determination of open and closed conformations of the protein. The analysis is based on a correlation between FTIR and X-ray dat
Publikováno v:
Journal of Enzyme Inhibition. 14:27-47
The action of an inhibitor on a stationary enzyme reaction is described by a simple equation, which reflects how the progressive binding of inhibitor molecules influences the existence and the productivity of the enzyme forms. This allows deduction o