Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Michèle Schwald"'
Autor:
Jean-Michel Aubry, Nicola Gervasoni, Gilles Bertschy, Michèle Schwald, Guido Bondolfi, Félicien Karege
Publikováno v:
Biological Psychiatry. 57:1068-1072
Background Recent reports have suggested a role for brain-derived neurotrophic factor (BDNF) in psychiatric disorders. Decreased serum BDNF levels have been reported in major depression, but the cause of this decrease has not yet been investigated. T
Publikováno v:
Molecular Brain Research. 136:29-37
Suicide is a major public health problem but the neurobiological factors of risk are poorly understood. Recent studies have mentioned changes in the serotoninergic system and in neuronal plasticity, as well. The present investigation was undertaken t
Autor:
Michèle Schwald, Guido Bondolfi, Félicien Karege, Nicola Gervasoni, Gilles Bertschy, Christian Osiek, Jean-Michel Aubry
Publikováno v:
Neuropsychobiology. 51:234-238
We had previously reported decreased serum brain-derived neurotrophic factor (BDNF) levels in depressed patients. In the present study, we tested the hypothesis that antidepressant treatment would normalize serum BDNF levels, at least in a subgroup o
Publikováno v:
Neuroscience Letters. 328:261-264
The brain-derived neurotrophic factor (BDNF) has been involved in pre- and postnatal brain development. Moreover, abundant levels of this neurotrophin have been found in animal and human brain and serum. This study was aimed to assess the postnatal c
Autor:
Guido Bondolfi, Jean-Michel Aubry, Michèle Schwald, Félicien Karege, Gilles Bertschy, Guillaume Perret
Publikováno v:
Psychiatry Research. 109:143-148
Recent findings with animal models have suggested a possible role for brain-derived neurotrophic factor (BDNF) in depression. We have therefore hypothesized that depression could be characterized by low levels of serum BDNF. Major depressed patients
Publikováno v:
Human Psychopharmacology: Clinical and Experimental. 15:191-197
The present work was aimed at assessing the GTP-binding (Galphas subunit) protein expression in lithium-treated bipolar patients (BP). Mononuclear leukocyte Galphas protein and mRNA were measured both in patients and in a comparison group. The patien
Publikováno v:
Neuropsychobiology. 39:181-186
Despite numerous suggestions of the involvement of GTP-binding proteins in the mechanisms of action of psychoactive drugs in bipolar affective disorder, few studies have been conducted during the drug treatment of patients. The aim of the present stu
Publikováno v:
Psychopharmacology, Vol. 205, No 3 (2009) pp. 419-429
RATIONALE: Lithium, some of the anticonvulsants, and several second-generation antipsychotic drugs are common medications widely prescribed to treat bipolar disorder. Molecular targets and cellular events that mediate their effects have been describe
Autor:
Michèle Schwald, S. Burkhardt, Alain Malafosse, Nader Perroud, Eladia Ballmann, Romano La Harpe, Félicien Karege
Publikováno v:
Biological psychiatry. 61(2)
Background Past studies in the neurobiology of suicide have reported alterations in serotonin and downstream effectors, such as Akt/protein kinase B. In this study, we aimed to examine possible abnormality in the Akt/glycogen synthase kinase-3β (GSK
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 29(4)
Bipolar affective disorder (BAD) is a severe disease whose molecular and cellular bases are not well known. The aim of the present study was to probe the cAMP signaling downstream targets by pharmacologically manipulating the protein kinase A (PKA) e