Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Michèle Sawadogo"'
Publikováno v:
Journal of Biological Chemistry. 279:15908-15915
The hyperglycemia-enhanced flux through the hexosamine biosynthetic pathway (HBP) has been implicated in the up-regulated gene expression of transforming growth factor-β1 (TGF-β1) in mesangial cells, thus leading to mesangial matrix expansion and d
Publikováno v:
Molecular Endocrinology. 14:1836-1848
Expression of the FSH receptor (FSHR) is limited to granulosa cells of the ovary and Sertoli cells of the testis. Previous studies showed that an E box in the proximal promoter of the FSHR gene is required for transcription and that the predominant E
Publikováno v:
Nucleic Acids Research. 28:2019-2025
In eukaryotic cells, mRNA synthesis is carried out by large, multifunctional complexes that are also involved in coordinating transcription with other nuclear processes. This survey focuses on the distribution and structural arrangement of these comp
Publikováno v:
Molecular and Cellular Biology. 19:4788-4797
The tissue-specific expression of major histocompatibility complex class I genes is determined by a series of upstream regulatory elements, many of which remain ill defined. We now report that a distal E-box element, located between bp -309 and -314
Publikováno v:
Proceedings of the National Academy of Sciences. 95:3758-3763
USF1 and USF2 are ubiquitously expressed transcription factors implicated as antagonists of the c-Myc protooncoprotein in the control of cellular proliferation. To determine the biological role of the USF proteins, mutant mice were generated by homol
Autor:
Xu Luo, Michèle Sawadogo
Publikováno v:
Proceedings of the National Academy of Sciences. 93:1308-1313
USF is a family of transcription factors characterized by a highly conserved basic-helix-loop-helix-leucine zipper (bHLH-zip) DNA-binding domain. Two different USF genes, termed USF1 and USF2, are ubiquitously expressed in both humans and mice. The U
Autor:
Michèle Sawadogo, Tao Lu
Publikováno v:
Journal of Biological Chemistry. 269:30694-30700
USF is a transcription factor characterized by a helix-loop-helix (HLH) DNA-binding domain that has been highly conserved through evolution. Vertebrate USFs contain an additional C-terminal leucine zipper (LZ) immediately adjacent to the HLH domain.
Publikováno v:
Molecular and Cellular Biology. 14:6896-6906
The mechanisms governing the function of cellular USF and herpesvirus immediate-early transcription factors are subjects of considerable interest. In this regard, we identified a novel form of coordinate gene regulation involving a cooperative interp
Publikováno v:
Analytical Biochemistry. 213:318-322
Using a human transcription factor, upstream stimulatory factor, as a model system, we developed a method for the rapid and efficient purification of proteins that interact with a cloned polypeptide expressed as a fusion with an oligohistidine domain
Publikováno v:
Gene. 111:99-104
Plasmid expression vectors have been constructed that direct the synthesis in Escherichia coli of fusion proteins containing a stretch of six histidine residues at either the N or C terminus. This oligo-histidine domain allows the single-step purific