Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Michèle Orain"'
Autor:
Fatemeh Vahidian, Fabien C. Lamaze, Cédrik Bouffard, François Coulombe, Andréanne Gagné, Florence Blais, Marion Tonneau, Michèle Orain, Bertrand Routy, Venkata S. K. Manem, Philippe Joubert
Publikováno v:
Cancers, Vol 16, Iss 4, p 708 (2024)
Background: Immune checkpoint inhibitors (ICIs) have revolutionized non-small cell lung cancers (NSCLCs) treatment, but only 20–30% of patients benefit from these treatments. Currently, PD-L1 expression in tumor cells is the only clinically approve
Externí odkaz:
https://doaj.org/article/59d448e038cc440d8bbd6c5648dca8c1
Autor:
Abdou Khadir Dia, Leyla Ebrahimpour, Sevinj Yolchuyeva, Marion Tonneau, Fabien C. Lamaze, Michèle Orain, Francois Coulombe, Julie Malo, Wiam Belkaid, Bertrand Routy, Philippe Joubert, Philippe Després, Venkata S. K. Manem
Publikováno v:
Cancers, Vol 16, Iss 2, p 348 (2024)
Background: Recent advances in cancer biomarker development have led to a surge of distinct data modalities, such as medical imaging and histopathology. To develop predictive immunotherapy biomarkers, these modalities are leveraged independently, des
Externí odkaz:
https://doaj.org/article/8cb07d2ae2a046aab1574cfa8f861f10
Autor:
Romain Villot, Audrey Poirier, Inan Bakan, Karine Boulay, Erlinda Fernández, Romain Devillers, Luciano Gama-Braga, Laura Tribouillard, Andréanne Gagné, Éma Duchesne, Danielle Caron, Jean-Sébastien Bérubé, Jean-Christophe Bérubé, Yan Coulombe, Michèle Orain, Yves Gélinas, Stéphane Gobeil, Yohan Bossé, Jean-Yves Masson, Sabine Elowe, Steve Bilodeau, Venkata Manem, Philippe Joubert, Frédérick A. Mallette, Mathieu Laplante
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
KEY FINDINGS ZNF768 is phosphorylated and degraded upon RAS activation ZNF768 depletion impairs proliferation and causes cellular senescence ZNF768 binds and represses p53 and its overexpression suffices to bypass senescence Elevated ZNF768 levels in
Externí odkaz:
https://doaj.org/article/8280dad19e4949b787cc212a7dfd3068
Autor:
Olga Sazonova, MD, MSc, Venkata Manem, MSc, PhD, Chloé Béland, MD, Marc-André Hamel, MD, Yves Lacasse, MD, Marie-Hélène Lévesque, MD, Michèle Orain, MT, David Joubert, MSc, PhD, Steeve Provencher, MD, David Simonyan, MSc, Philippe Joubert, MD, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 1, Iss 4, Pp 100078- (2020)
Introduction: Diffuse idiopathic pulmonary neuroendocrine hyperplasia (DIPNECH) is a rare condition that is likely underdiagnosed owing to the lack of established and validated diagnostic criteria. These clinical guidelines are empirical and created
Externí odkaz:
https://doaj.org/article/1f041503452945db88b735d133be041a
Autor:
Andrée-Anne Grosset, Frédérick Dallaire, Tien Nguyen, Mirela Birlea, Jahg Wong, François Daoust, Noémi Roy, André Kougioumoutzakis, Feryel Azzi, Kelly Aubertin, Samuel Kadoury, Mathieu Latour, Roula Albadine, Susan Prendeville, Paul Boutros, Michael Fraser, Rob G Bristow, Theodorus van der Kwast, Michèle Orain, Hervé Brisson, Nazim Benzerdjeb, Hélène Hovington, Alain Bergeron, Yves Fradet, Bernard Têtu, Fred Saad, Frédéric Leblond, Dominique Trudel
Publikováno v:
PLoS Medicine, Vol 17, Iss 8, p e1003281 (2020)
BACKGROUND:Prostate cancer (PC) is the most frequently diagnosed cancer in North American men. Pathologists are in critical need of accurate biomarkers to characterize PC, particularly to confirm the presence of intraductal carcinoma of the prostate
Externí odkaz:
https://doaj.org/article/8fcceac90c674478ae01e4c367277d85
Autor:
Andréanne Gagné, Bernard Têtu, Michèle Orain, Stéphane Turcotte, Marie Plante, Jean Grégoire, Marie-Claude Renaud, Isabelle Bairati, Dominique Trudel
Publikováno v:
Diagnostic Pathology, Vol 13, Iss 1, Pp 1-9 (2018)
Abstract Background The expression of high temperature requirement factor A1 (Htra1) has been reported to be decreased in ovarian carcinoma, but its prognostic effect remains undetermined. Methods We evaluated the impact of HtrA1 downregulation in tu
Externí odkaz:
https://doaj.org/article/a4a66144d0724d3c995194fecbb3cfc0
Autor:
Audrey Poirier, Andréanne Gagné, Philippe Laflamme, Meagan Marcoux, Michèle Orain, Sophie Plante, David Joubert, Philippe Joubert, Mathieu Laplante
Publikováno v:
Cancers, Vol 13, Iss 16, p 4136 (2021)
Lung adenocarcinoma (LUAD) is the most common type of lung cancer and a leading cause of cancer-related deaths worldwide. Despite important recent advances, the prognosis for LUAD patients is still unfavourable, with a 5 year-survival rate close to 1
Externí odkaz:
https://doaj.org/article/35bd5ce557374a938786866e0976b7a4
Autor:
Mirette Hanna, Isabelle Dumas, Michèle Orain, Simon Jacob, Bernard Têtu, François Sanschagrin, Alexandre Bureau, Brigitte Poirier, Caroline Diorio
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183579 (2017)
Increased levels of pro-inflammatory markers and decreased levels of anti-inflammatory markers in the breast tissue can result in local inflammation. We aimed to investigate whether local inflammation in the breast tissue is associated with age-relat
Externí odkaz:
https://doaj.org/article/124f9fd5c23c4de4bcec67a6d124fe0d
Autor:
Andréanne Gagné, Bernard Têtu, Michèle Orain, Stéphane Turcotte, Marie Plante, Jean Grégoire, Marie-Claude Renaud, Isabelle Bairati, Dominique Trudel
Publikováno v:
Diagnostic Pathology, Vol 13, Iss 1, Pp 1-1 (2018)
It has been highlighted that the original article [1] contained a typesetting mistake in the family name of Dominique Trudel.
Externí odkaz:
https://doaj.org/article/f32e04dc608d4c80ae3797779f46edd7
Autor:
Yohan Bossé, Andréanne Gagné, Wajd A. Althakfi, Michèle Orain, Christian Couture, Sylvain Trahan, Sylvain Pagé, David Joubert, Pierre O. Fiset, Patrice Desmeules, Philippe Joubert
Publikováno v:
American Journal of Surgical Pathology. 47:686-693