CD117hi expression identifies a human fetal hematopoietic stem cell population with high proliferation and self-renewal potential

Autor: Loïc Maillard, Sandra Sanfilippo, Carine Domenech, Nassima Kasmi, Laurence Petit, Sébastien Jacques, Anne-Lise Delezoide, Fabien Guimiot, Soria Eladak, Delphine Moison, Nour Nicolas, Virginie Rouiller-Fabre, Stéphanie Pozzi-Godin, Benoit Mennesson, Marie-Laure Brival, Franck Letourneur, Thierry Jaffredo, Christine Chomienne, Michèle Souyri

Publikováno v: Haematologica, Vol 105, Iss 2 (2020)

Externí odkaz: https://doaj.org/article/79ddf9e9e0c84486b97264d36c9a8590

Clonal hematopoiesis driven by chromosome 1q/MDM4 trisomy defines a canonical route toward leukemia in Fanconi anemia

Autor: Marie Sebert, Stéphanie Gachet, Thierry Leblanc, Alix Rousseau, Olivier Bluteau, Rathana Kim, Raouf Ben Abdelali, Flore Sicre de Fontbrune, Loïc Maillard, Carèle Fedronie, Valentine Murigneux, Léa Bellenger, Naira Naouar, Samuel Quentin, Lucie Hernandez, Nadia Vasquez, Mélanie Da Costa, Pedro H. Prata, Lise Larcher, Marie de Tersant, Matthieu Duchmann, Anna Raimbault, Franck Trimoreau, Odile Fenneteau, Wendy Cuccuini, Nathalie Gachard, Nathalie Auger, Giulia Tueur, Maud Blanluet, Claude Gazin, Michèle Souyri, Francina Langa Vives, Aaron Mendez-Bermudez, Hélène Lapillonne, Etienne Lengline, Emmanuel Raffoux, Pierre Fenaux, Lionel Adès, Edouard Forcade, Charlotte Jubert, Carine Domenech, Marion Strullu, Bénédicte Bruno, Nimrod Buchbinder, Caroline Thomas, Arnaud Petit, Guy Leverger, Gérard Michel, Marina Cavazzana, Eliane Gluckman, Yves Bertrand, Nicolas Boissel, André Baruchel, Jean-Hugues Dalle, Emmanuelle Clappier, Eric Gilson, Ludovic Deriano, Sylvie Chevret, François Sigaux, Gérard Socié, Dominique Stoppa-Lyonnet, Hugues de Thé, Christophe Antoniewski, Dominique Bluteau, Régis Peffault de Latour, Jean Soulier

Publikováno v: Cell Stem Cell
Cell Stem Cell, 2023, 30 (2), pp.153-170.e9. ⟨10.1016/j.stem.2023.01.006⟩

International audience; Fanconi anemia (FA) patients experience chromosome instability, yielding hematopoietic stem/progenitor cell (HSPC) exhaustion and predisposition to poor-prognosis myeloid leukemia. Based on a longitudinal cohort of 335 patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c04c73d99e0cccd9d3216befe9e7cea
https://hal.science/hal-04157812

Endoglin expression level discriminates long-term hematopoietic from short-term clonogenic progenitor cells in the aorta

Autor: Marion Roques, Charles Durand, Rodolphe Gautier, Pierre-Yves Canto, Laurence Petit-Cocault, Laurent Yvernogeau, Dominique Dunon, Michèle Souyri, Thierry Jaffredo

Publikováno v: Haematologica, Vol 97, Iss 7 (2012)

CD105 is an auxiliary receptor for the transforming growth factor beta superfamily, highly expressed on proliferating endothelial cells and adult hematopoietic stem cells. Because CD105 mRNA expression was reported in the developing aortic region, we

Externí odkaz: https://doaj.org/article/ea2fc1d1cd554efebd75268c160fe432

In vivo generation of haematopoietic stem/progenitor cells from bone marrow-derived haemogenic endothelium

Autor: Laurent Yvernogeau, Michèle Souyri, Pierre Charbord, Laurence Petit, Hanane Khoury, Helen Sang, Rodolphe Gautier, Vanessa Ribes, Catherine Robin, Thierry Jaffredo, Frédéric Relaix

Publikováno v: Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, 2019, 21 (11), pp.1334-1345. ⟨10.1038/s41556-019-0410-6⟩
Yvernogeau, L, Gautier, R, Petit, L, Khoury, H, Relaix, F, Ribes, V, Sang, H, Charbord, P, Souyri, M, Robin, C & Jaffredo, T 2019, ' In vivo generation of haematopoietic stem/progenitor cells from bone marrow-derived haemogenic endothelium ', Nature Cell Biology, vol. 21, pp. 1334-1345 . https://doi.org/10.1038/s41556-019-0410-6
Nature Cell Biology, 21(11), 1334-1345. Nature Publishing Group

It is well established that haematopoietic stem and progenitor cells (HSPCs) are generated from a transient subset of specialized endothelial cells termed haemogenic, present in the yolk sac, placenta and aorta, through an endothelial-to-haematopoiet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4193cdc3333ab2d86e9ed79c8471a2
https://hal.archives-ouvertes.fr/hal-02994468

3004 – IDENTIFICATION AND CHARACTERIZATION OF NOVEL FUNCTIONAL MARKERS DURING THE HEMATOPOIETIC STEM CELL SPECIFICATION PROCESS

Autor: David Hills, Irem Bayindir-Buchhalter, Marleen Büchler-Schäff, Wenjun Chang, Michael D. Milsom, Stella Pfaffenholz, Michèle Souyri, Julius Gräsel, Georges Lacaud, Sabrina Hanke, Roshana Thambyrajah, Wiebke Nadler, Alexander Medvinsky, Richard Harbottle, Milena Block, Paul Kaschutnig, Chrisoph Rösli, Jakob Kremer

Publikováno v: Experimental Hematology. 88:S38

Endothelial to hematopoietic transition (EHT) is a crucial step in the formation of definitive hematopoietic stem cells during embryonic development. Holding such a critical developmental role not many details regarding molecular changes and cell sur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd402e7e1ae78efa4309f37187dcc24b
https://doi.org/10.1016/j.exphem.2020.09.026