Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Michèl R. Klein"'
Autor:
Pele Chong, Michèl R. Klein
Publikováno v:
Human Vaccines & Immunotherapeutics. 11:2688-2704
Enterovirus A infections are the primary cause of hand, foot and mouth disease (HFMD) in infants and young children. Although enterovirus 71 (EV-A71) and coxsackievirus A16 (CV-A16) are the predominant causes of HFMD epidemics worldwide, EV-A71 has e
Autor:
Annemieke H. Friggen, T. B. K. Reddy, S. M. Arend, Michèl R. Klein, Marleen J. C. Verduyn, Tom H. M. Ottenhoff, Krista E. van Meijgaarden, Kees L. M. C. Franken, Gary K. Schoolnik, May Young Lin
Publikováno v:
Infection and Immunity. 77:5071-5079
Mycobacterium tuberculosis DosR regulon-encoded antigens are highly immunogenic in M. tuberculosis -infected humans and are associated with latent tuberculosis infection. We have investigated the hypothesis that infection with or exposure to nontuber
Autor:
Kees L. M. C. Franken, Maytal Bivas-Benita, Suzanne M. Bal, Annemieke H. Friggen, May Young Lin, Gerrit Borchard, Tom H. M. Ottenhoff, Krista E. van Meijgaarden, Hans E. Junginger, Michèl R. Klein
Publikováno v:
Vaccine, Vol. 27, No 30 (2009) pp. 4010-4017
During persistent infection and hypoxic-stress, Mycobacterium tuberculosis (Mtb) expresses a series of Mtb latency antigens. The aim of this study was to evaluate the immunogenicity of a DNA vaccine encoding the Mtb latency antigen Rv1733c and to exp
Autor:
Angelo Izzo, Martin I. Voskuil, Ryan W. Honaker, Michèl R. Klein, Amanda L. Stewart, Stephanie A. Schittone
Publikováno v:
Infection and Immunity. 76:2587-2593
Mycobacterium tuberculosis is the causative agent of tuberculosis, a disease that affects one-third of the world's population. The sole extant vaccine for tuberculosis is the live attenuated Mycobacterium bovis bacillus Calmette-Guerin (BCG). We exam
Autor:
Kees L. M. C. Franken, Kris Huygen, Lei Zhang, Tom H. M. Ottenhoff, Marta Romano, Virginie Roupie, May Young Lin, Hannelie Korf, Michèl R. Klein
Publikováno v:
Infection and Immunity. 75:941-949
Hypoxia and low concentrations of nitric oxide have been reported to upregulate in vitro gene expression of 48 proteins of the dormancy (DosR) regulon of Mycobacterium tuberculosis . These proteins are thought to be essential for the survival of bact
Autor:
May Young Lin, Corine Prins, Martin I. Voskuil, Sandra M. Arend, Annemieke H. Friggen, Kees L. M. C. Franken, Peter Andersen, Tom H. M. Ottenhoff, Eliane M. S. Leyten, Karin Weldingh, Krista E. van Meijgaarden, Gary K. Schoolnik, Michèl R. Klein
Publikováno v:
Microbes and Infection. 8:2052-2060
The dormancy (DosR) regulon of Mycobacterium tuberculosis is expressed in vitro during hypoxia and low-dose nitric oxide stimulation. Tubercle bacilli are thought to encounter these conditions in humans during latent infection. In this study, immune
Autor:
Arend J. Kolk, Tom H. M. Ottenhoff, Sergio C. Oliveira, Kees L. M. C. Franken, Krista E. Meijgaarden, Michèl R. Klein, Clarice Abramo, Henrique Couto Teixeira, Daniely Garcia
Publikováno v:
Microbes and Infection. 8:45-51
IFN-c responses to Mycobacterium tuberculosis antigens ESAT-6 and CFP-10 have been proposed as specific markers of M. tuberculosis infection. Monokine induced by gamma interferon (MIG/CXCL9) has been shown to be expressed by IFN-c stimulated mononucl
Autor:
Paul R. Klatser, Elizabeth P. Sampaio, Krista E. van Meijgaarden, Kelly Cristina Pereira, Brigitte Wieles, John S. Spencer, Kees L. M. C. Franken, Michèl R. Klein, Tom H. M. Ottenhoff, Maria Cristina Vidal Pessolani, Annemieke Geluk, Samira Bührer-Sékula, Patrick J. Brennan, Diana L. Williams
Publikováno v:
Infection and immunity, 73(9), 5636-5644. American Society for Microbiology
Early detection of Mycobacterium leprae infection is considered an important component of strategies aiming at reducing transmission of infection, but currently available diagnostic tools often lack sufficient sensitivity and specificity to reach thi
Publikováno v:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 60(5)
Enterovirus 71 (EV71) and coxsackieviruses are the major causative agents of hand, foot, and mouth disease (HFMD) outbreaks worldwide and have a significant socioeconomic impact, particularly in Asia. Formalin-inactivated (FI) EV71 vaccines evaluated
Publikováno v:
Vaccine. 32(47)
Enterovirus 71 (EV71), an emerging neurotropic virus and coxsackieviruses (CV) are the major causative agents of hand, foot and mouth diseases (HFMD). These viruses have become a serious public health threat in the Asia Pacific region. Formalin-inact