Splenic Transcriptional Responses in Severe Visceral Leishmaniasis: Impaired Leukocyte Chemotaxis and Cell Cycle Arrest

Autor: Caroline Vilas Boas de Melo, Felipe Guimarães Torres, Micely D’El-Rei Hermida, Jonathan L. M. Fontes, Bianca Ramos Mesquita, Reginaldo Brito, Pablo Ivan P. Ramos, Gabriel R. Fernandes, Luiz Antônio Rodrigues Freitas, Ricardo Khouri, Carlos Henrique Nery Costa, Washington L. C. dos-Santos

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Structural changes in the spleen have been reported in several infectious diseases. In visceral leishmaniasis (VL), a severe parasitic disease caused by Leishmania spp., the loss of white pulp accompanies a severe clinical presentation. Hamster model

Externí odkaz: https://doaj.org/article/4e144ad9b0484102a3c0edf2d8144b85

Histological Disorganization of Spleen Compartments and Severe Visceral Leishmaniasis

Autor: Micely d'El-Rei Hermida, Caroline Vilas Boas de Melo, Isadora dos Santos Lima, Geraldo Gileno de Sá Oliveira, Washington L. C. dos-Santos

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)

The spleen is a secondary lymphoid organ responsible for immune surveillance against blood-circulating pathogens. Absence of the spleen is associated with increased susceptibility to systemic spread and fatal infection by different pathogens. Severe

Externí odkaz: https://doaj.org/article/bdc8226277c349dab10faf2c2a0b5385

Phenotypical Characterization of Spleen Remodeling in Murine Experimental Visceral Leishmaniasis

Autor: Girlândia B.S. Mota, Jasper J. Koning, Reina E. Mebius, Jonathan L. M. Fontes, Micely D’El-Rei Hermida, Bruno B. Benevides, Caroline Vilas Boas de Melo, Luiz Antonio Rodrigues de Freitas, Washington Luis Conrado dosSantos, Manuela da Silva Solcà, Bianca Ramos Mesquita

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, 11:653
Frontiers in Immunology, Vol 11 (2020)
Melo, C V B D, Hermida, M D E R, Mesquita, B R, Fontes, J L M, Koning, J J, Solcà, M D S, Benevides, B B, Mota, G B S, Freitas, L A R, Mebius, R E & dos-Santos, W L C 2020, ' Phenotypical Characterization of Spleen Remodeling in Murine Experimental Visceral Leishmaniasis ', Frontiers in Immunology, vol. 11, 653 . https://doi.org/10.3389/fimmu.2020.00653

Background: Visceral leishmaniasis (VL) is caused by Leishmania infantum or L. donovani infection. One of the main problems related to this disease is the emergence of severe clinical forms with a lethality of 5–20%, even while under specific treat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc6ff4171ebea20bf66c65603367d410
https://doi.org/10.3389/fimmu.2020.00653

LeishmaniaInfection Impairs β1-Integrin Function and Chemokine Receptor Expression in Mononuclear Phagocytes

Autor: Mariana Petaccia de Macedo, Nathanael F. Pinheiro, Washington Luis Conrado dosSantos, José Mengel, Micely D’El-Rei Hermida, André Báfica

Publikováno v: Infection and Immunity. 74:3912-3921

Leishmaniaspp. are intracellular parasites that cause lesions in the skin, mucosa, and viscera. We have previously shown thatLeishmaniainfection reduces mononuclear phagocyte adhesion to inflamed connective tissue. In this study, we examined the role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3176e9a67934f3e9e69f25090c603383
https://doi.org/10.1128/iai.02103-05

A Transcriptomic Network Identified in Uninfected Macrophages Responding to Inflammation Controls Intracellular Pathogen Survival

Autor: Asher Maroof, Dimitris Lagos, John W. J. Moore, Micely d’El-Rei Hermida, Najmeeyah Brown, Paul M. Kaye, Lynette Beattie

Publikováno v: Cell Host & Microbe

Summary Intracellular pathogens modulate host cell function to promote their survival. However, in vitro infection studies do not account for the impact of host-derived inflammatory signals. Examining the response of liver-resident macrophages (Kupff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::889dd408b2baa572a46c8dcb50d90c61