Výsledky vyhledávání

Estimation of the octanol-water distribution coefficient of basic compounds by a cationic microemulsion electrokinetic chromatography system

Autor: Elisabet Fuguet, Susana Amézqueta, Alejandro Fernández-Pumarega, Belén Martín-Sanz, Martí Rosés

Publikováno v: ADMET and DMPK, Vol 8, Iss 1, Pp 98-112 (2020)
ADMET and DMPK
Volume 8
Issue 1
Dipòsit Digital de la UB
Universidad de Barcelona

The octanol-water partition coefficient (Po/w), or the octanol-water distribution coefficient (Do/w) for ionized compounds, is a key parameter in the drug development process. In a previous work, this parameter was estimated through the retention fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db0ccd59a7c0c201d8000f6abc94288
https://doi.org/10.5599/admet.760

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Controlled thermo-responsive hydrogels based on the stereocomplexed block of PLA-PEG-PLA for tissue engineering

Autor: Comas Iwasita, Eisuke

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona

Treballs Finals de Grau de Química, Facultat de Química, Universitat de Barcelona, Any: 2021, Tutors: Elena Xuriguera Martin, Oscar Castaño Linares
Nowadays one of the main causes of death is cardiovascular diseases, principally cardiac failu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::95e34023bdcde3f402bc43908b840fe7
http://hdl.handle.net/2445/180024

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Poly-ion complex micelle effectively delivers CoA- conjugated CPT1A inhibitors to modulate lipid metabolism in brain cells

Autor: Laura Herrero, Jordi Garcia, Hiroaki Kinoh, Shigeto Fukushima, Rosalía Rodríguez-Rodríguez, Núria Casals, Yuki Mochida, Jesús Garcia-Chica, Kazunori Kataoka, Sabina Quader, Dolors Serra, West Kristian D. Paraiso, Sebastián Zagmutt, Xavier Ariza

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona

Carnitine palmitoyltransferase 1A (CPT1A) is a central player in lipid metabolism, catalyzing the first step to fatty acid oxidation (FAO). Inhibiting CPT1A, especially in the brain, can have several pharmacological benefits, such as in treating obes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97531899c73ccc312bcf24533ca2505
http://hdl.handle.net/2445/180168

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Real-time Ratiometric Imaging of Micelles Assembly State in a Microfluidic Cancer-on-a-chip

Autor: Romen Rodriguez-Trujillo, Lorenzo Albertazzi, Natalia Feiner-Gracia, Marina Buzhor, Silvia Pujals, Adrianna Glinkowska Mares, Josep Martí, Roey J. Amir

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
ACS Applied Bio Materials
ACS Applied Bio Materials, 4(1), 669-681. American Chemical Society

The performance of supramolecular nanocarriers as drug delivery systems depends on their stability in the complex and dynamic biological media. After administration, nanocarriers are challenged by confronting different barriers such as shear stress a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd926d7a3b4f72f3fe59b81e7f27147
https://doi.org/10.1101/2020.03.08.978783

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Prediction of Partition Coefficients in SDS Micelles by DFT Calculations

Autor: Leila Saranjam, Vasil Simeonov, Sergio Madurga, Francesc Mas, Miroslava Nedyalkova, Elisabet Fuguet

Publikováno v: Symmetry, Vol 13, Iss 1750, p 1750 (2021)
Dipòsit Digital de la UB
Universidad de Barcelona
Symmetry
Volume 13
Issue 9

A computational methodology using Density-Functional Theory (DFT) calculations was developed to determine the partition coefficient of a compound in a solution of Sodium Dodecyl Sulfate (SDS) micelles. Different sets of DFT calculations were used to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b0ec305a5d693b98d30ccb61f1dd98
https://doi.org/10.3390/sym13091750

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Supramolecular block copolymers incorporating chiral and achiral chromophores for the bottom-up assembly of nanomaterials

Autor: David B. Amabilino, Arántzazu González Campo, Marta Riba Moliner, Cristina Oliveras Gonzalez

Publikováno v: UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Recercat. Dipósit de la Recerca de Catalunya
instname
Digital.CSIC. Repositorio Institucional del CSIC

This paper is part of the 2019 Women in porphyrin science special issue.
The coordination of the chiral metalloporphyrin ([5,10,15,20-[4-(R,R,R,R)-2-N-octadecylamidoethyloxiphenyl]porphyrin] zinc (II)) and an achiral homologue to an amphiphilic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2bb57ada6c024041cab8ef79fbb15df
http://hdl.handle.net/10261/202759

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Estimation of the octanol–water distribution coefficient of acidic compounds by microemulsion electrokinetic chromatography

Autor: Susana Amézqueta, Elisabet Fuguet, Alejandro Fernández-Pumarega, Martí Rosés

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona

The feasibility of extending the determination of the lipophilicity of partially ionized acids (log Do/w) by microemulsion electrokinetic chromatography (MEEKC) is tested. Theoretical considerations predict that a linear log Do/w vs. log k correlatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3621039fcd00eecf1dec5277c143d3b
https://doi.org/10.1016/j.jpba.2019.112981

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Mean-Field Coarse-Grained Model for Poly(ethylene oxide)-Poly(propylene oxide)-Poly(ethylene oxide) Triblock Copolymer Systems

Autor: Allan D. Mackie, Alexander J. Colville, Fabián A. García Daza

Publikováno v: Langmuir
Repositori Institucional de la Universitat Rovira i Virgili
Universitat Rovira i virgili (URV)

The microscopic modeling of surfactant systems is of the utmost importance in understanding the mechanisms related to the micellization process because it allows for prediction and comparison with experimental data of diverse equilibrium system prope

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87edf6100ac5425f73bfb31d2e3713a8
https://doi.org/10.1021/la504884m

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Modeling aquatic toxicity through chromatographic systems

Autor: Elisabet Fuguet, Susana Amézqueta, Martí Rosés, Laura Muñoz-Pascual, Sandra Farré, Michael H. Abraham, Alejandro Fernández-Pumarega

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona

Environmental risk assessment requires information about the toxicity of the growing number of chemical products coming from different origins that can contaminate water and become toxicants to aquatic species or other living beings via the trophic c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db1e526195d5a00aacd42f13e3cdc96
http://hdl.handle.net/2445/162022

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