Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Micah Simmons"'
Autor:
Skylar E. Davis, Anna K. Cook, Justin A. Hall, Yuliya Voskobiynyk, Nancy V. Carullo, Nicholas R. Boyle, Ahmad R. Hakim, Kristian M. Anderson, Kierra P. Hobdy, Derian A. Pugh, Charles F. Murchison, Laura J. McMeekin, Micah Simmons, Katherine A. Margolies, Rita M. Cowell, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, Bruce L. Miller, William W. Seeley, Andrew E. Arrant
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract Loss of function progranulin (GRN) mutations are a major autosomal dominant cause of frontotemporal dementia (FTD). Patients with FTD due to GRN mutations (FTD-GRN) develop frontotemporal lobar degeneration with TDP-43 pathology type A (FTLD
Externí odkaz:
https://doaj.org/article/cb7d9e8149f4472c81b6d7612826356c
Autor:
Xiaojun Wu, James Reigle, Erica A K DePasquale, James H. Meador-Woodruff, Vahram Haroutunian, Rammohan Shukla, Emily Devine, Margaret Hahn, Micah Simmons, Christy Au-Yeung, Khaled Alganem, Jarek Meller, Chang-Gyu Hahn, Xiaolu Zhang, Hunter M. Eby, Roshanak Asgariroozbehani, Robert E. McCullumsmith
Publikováno v:
Molecular psychiatry. 26(12)
While the pathophysiology of schizophrenia has been extensively investigated using homogenized postmortem brain samples, few studies have examined changes in brain samples with techniques that may attribute perturbations to specific cell types. To fi
Autor:
Khaled Alganem, James Reigle, Robert E. McCullumsmith, Rammohan Shukla, James H. Meador-Woodruff, Xiaojun Wu, Chang-Gyu Hahn, Jarek Meller, Erica A K DePasquale, Vahram Haroutunian, Micah Simmons
While the pathophysiology of schizophrenia has been extensively investigated using homogenized postmortem brain samples, few studies have examined changes in brain samples with techniques that may attribute perturbations to specific cell types. To fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dbf8d41a4690fc9a72f0d63682fd297
https://doi.org/10.1101/2020.01.14.906214
https://doi.org/10.1101/2020.01.14.906214
Autor:
Ying Zhou, James H. Meador-Woodruff, Micah Simmons, Hongjun Song, Junmin Peng, Bing Bai, Zhexing Wen, Eduard Bentea, Erica A K DePasquale, Courtney R. Sullivan, Guo Li Ming, Jarek Meller, Sinead M. O’Donovan, Chongchong Xu, Robert E. McCullumsmith
Protein kinases orchestrate signal transduction pathways involved in central nervous system functions ranging from neurodevelopment to synaptic transmission and plasticity. Abnormalities in kinase-mediated signaling are involved in the pathophysiolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155a4385668dd58364d5c82cba0af436
https://biblio.vub.ac.be/vubir/kinase-network-dysregulation-in-a-human-induced-pluripotent-stem-cell-model-of-disc1-schizophrenia(22758346-5d00-46d6-9ad3-bcacf72cf99f).html
https://biblio.vub.ac.be/vubir/kinase-network-dysregulation-in-a-human-induced-pluripotent-stem-cell-model-of-disc1-schizophrenia(22758346-5d00-46d6-9ad3-bcacf72cf99f).html
Altered protein post-translational modifications such as glycosylation have become a target of investigation in the pathophysiology of schizophrenia. Disrupted glycosylation associated processes including atypical sphingolipid metabolism, reduced pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d334d60e7801660385b3e1a2c453af
https://doi.org/10.1101/369314
https://doi.org/10.1101/369314
Autor:
James H. Meador-Woodruff, Vahram Haroutunian, Sinead M. O’Donovan, Micah Simmons, Robert E. McCullumsmith, F S Benesh, Tara L. Lauriat, Rosalinda C. Roberts, Jana B. Drummond
Publikováno v:
Mol Psychiatry
Excitatory amino-acid transporters (EAATs) bind and transport glutamate, limiting spillover from synapses due to their dense perisynaptic expression primarily on astroglia. Converging evidence suggests that abnormalities in the astroglial glutamate t
Autor:
Laurence D. McMillan, Anita Pinner, Vahram Haroutunian, Micah Simmons, Janusz Tucholski, James H. Meador-Woodruff
Publikováno v:
NeuroReport. 24:688-691
Dysfunctional glutamate neurotransmission has been implicated in the pathophysiology of schizophrenia. Abnormal expressions in schizophrenia of ionotropic glutamate receptors (iGluRs) and the proteins that regulate their trafficking have been found t
Autor:
Vahram Haroutunian, Janusz Tucholski, Robert E. McCullumsmith, Anita Pinner, James H. Meador-Woodruff, Micah Simmons
Publikováno v:
Schizophrenia Research. 146:177-183
Numerous studies have demonstrated brain region- and subunit-specific abnormalities in the expression of subunits of the AMPA subtype of glutamate receptors in schizophrenia. In addition, abnormalities in the expression of proteins that regulate the
Autor:
Jana B. Drummond, Micah Simmons, Tara L. Lauriat, Rosalinda C. Roberts, James H. Meador-Woodruff, Sinead M. O’Donovan, Vahram Haroutunian, Robert E. McCullumsmith, F S Benesh
Publikováno v:
Molecular psychiatry. 21(6)
Shaping plasticity: Alterations in glutamate transporter localization as a pathophysiological mechanism in severe mental illness
Schizophrenia is a severe psychiatric disorder that is characterized by a wide array of symptoms and a complex neuropathology. A well-characterized neurobiological feature of schizophrenia is abnormal synaptic plasticity, although the mechanisms unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848e8f5488f2ddff5913b6f8b386fac0
https://europepmc.org/articles/PMC4733612/
https://europepmc.org/articles/PMC4733612/