Výsledky vyhledávání - "Micah J. Maxwell"

Akademický článek

Dual mTORC1/2 inhibition compromises cell defenses against exogenous stress potentiating Obatoclax-induced cytotoxicity in atypical teratoid/rhabdoid tumors

Autor: Ashlyn Parkhurst, Sabrina Z. Wang, Tyler R. Findlay, Kristen J. Malebranche, Arman Odabas, Jesse Alt, Micah J. Maxwell, Harpreet Kaur, Cody J. Peer, William D. Figg, Katherine E. Warren, Barbara S. Slusher, Charles G. Eberhart, Eric H. Raabe, Jeffrey A. Rubens

Publikováno v: Cell Death and Disease, Vol 13, Iss 4, Pp 1-14 (2022)

Abstract Atypical teratoid/rhabdoid tumors (AT/RT) are the most common malignant brain tumors of infancy and have a dismal 4-year event-free survival (EFS) of 37%. We have previously shown that mTOR activation contributes to AT/RT’s aggressive grow

Externí odkaz: https://doaj.org/article/10b90ebb273a45c786ac0a49aa2935b6

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Novel Glutamine Antagonist JHU395 Suppresses MYC-Driven Medulloblastoma Growth and Induces Apoptosis

Autor: Rana Rais, Charles G. Eberhart, Eric H. Raabe, Khoa Pham, Micah J. Maxwell, Heather Sweeney, Barbara S. Slusher, Jesse Alt

Publikováno v: J Neuropathol Exp Neurol

Medulloblastoma is the most common malignant pediatric brain tumor. Amplification of c-MYC is a hallmark of a subset of poor-prognosis medulloblastoma. MYC upregulates glutamine metabolism across many types of cancer. We modified the naturally occurr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e94bea639e450c9ad2f367638e4d27f
https://doi.org/10.1093/jnen/nlab018

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Abstract LB143: Improving treatment outcomes: a digital solution for remote patient monitoring of stomatitis for patients receiving Dato-DXd

Autor: Rebecca H. Wray, Elisabeth Piault, Lucie Miller-Potucka, Jill A. Bell, Rick Fairhurst, Sabrina S. Khan, Micah J. Maxwell, Neelima Denduluri, Leora Horn

Publikováno v: Cancer Research. 83:LB143-LB143

Instances of stomatitis are very painful and compromise nutrition and oral hygiene as well as induce an increased risk for local and systemic infection. Stomatitis is a well-known toxicity of radiotherapy, chemotherapy and other targeted therapies an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2366dbb87f6e371b9ea534bef37c8ade
https://doi.org/10.1158/1538-7445.am2023-lb143

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Dual mTORC1/2 inhibition compromises cell defenses against exogenous stress potentiating Obatoclax-induced cytotoxicity in atypical teratoid/rhabdoid tumors

Publikováno v: Cell deathdisease. 13(4)

Atypical teratoid/rhabdoid tumors (AT/RT) are the most common malignant brain tumors of infancy and have a dismal 4-year event-free survival (EFS) of 37%. We have previously shown that mTOR activation contributes to AT/RT’s aggressive growth and po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e97cc188fc27dc841e963812cb09b0
https://pubmed.ncbi.nlm.nih.gov/35484114

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Unbiased Proteomic and Phosphoproteomic Analysis Identifies Response Signatures and Novel Susceptibilities After Combined MEK and mTOR Inhibition in BRAFV600E Mutant Glioma

Autor: Jeffrey Rubens, David J. Clark, Lijun Chen, Antje Arnold, Micah J. Maxwell, Hui Zhang, Eric H. Raabe, Tung-Shing M. Lih, Michael Schnaubelt, Heather Sweeney, Charles G. Eberhart

Publikováno v: Molecular & Cellular Proteomics : MCP

The mitogen-activated protein kinase pathway is one of the most frequently altered pathways in cancer. It is involved in the control of cell proliferation, invasion, and metabolism, and can cause resistance to therapy. A number of aggressive malignan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbad6edd54a95268217095d4ba24909d
http://europepmc.org/articles/PMC8363840

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Comprehensive Metabolic Profiling of MYC-Amplified Medulloblastoma Tumors Reveals Key Dependencies on Amino Acid, Tricarboxylic Acid and Hexosamine Pathways

Autor: Khoa Pham, Allison R. Hanaford, Brad A. Poore, Micah J. Maxwell, Heather Sweeney, Akhila Parthasarathy, Jesse Alt, Rana Rais, Barbara S. Slusher, Charles G. Eberhart, Eric H. Raabe

Publikováno v: Cancers; Volume 14; Issue 5; Pages: 1311

Reprograming of cellular metabolism is a hallmark of cancer. Altering metabolism allows cancer cells to overcome unfavorable microenvironment conditions and to proliferate and invade. Medulloblastoma is the most common malignant brain tumor of childr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0ef0ee81340e5d04a2dcdd570e4a19
https://doi.org/10.3390/cancers14051311

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Abstract 2321: Comprehensive metabolic profiling of high MYC medulloblastoma revealed key differences between in vitro and in vivo in glucose and glutamine usage

Autor: Eric H. Raabe, Allison Hanaford, Bradley Poore, Heather Sweeney, Akhila Parthasarathy, Rana Rais, Khoa Pham, Charles G. Eberhart, Jesse Alt, Micah J. Maxwell, Barbara S. Slusher

Publikováno v: Cancer Research. 81:2321-2321

Medulloblastoma is the most common malignant brain tumor of children. Genomic amplification of MYC is a hallmark of a subset of poor-prognosis medulloblastoma. In other cancers, high-level expression of MYC increase glutamine transport and fuels the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2cfcf0f9bc4b098eb7213142d1b4ab25
https://doi.org/10.1158/1538-7445.am2021-2321

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Abstract 324: Unbiased proteomic and phosphoproteomic analysis identifies response signatures and novel susceptibilities after combined MEK and mTOR inhibition in BRAFV600E mutant glioma

Autor: David J. Clark, Eric H. Raabe, Tung-Shing M. Lih, Hui Zhang, Antje Arnold, Michael Schnaubelt, Ljun Chen, Jeffrey A. Rubens, Micah J. Maxwell, Charles G. Eberhart, Heather Sweeney

Publikováno v: Cancer Research. 81:324-324

The mitogen-activated protein kinase (MAPK) pathway is one of the most frequently altered pathways in cancer. It is involved in the control of cell proliferation, invasion, metabolism, and can cause resistance to therapy. A number of aggressive malig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7162301fa81f085fd73a2ffe7b062c90
https://doi.org/10.1158/1538-7445.am2021-324

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OTME-9. Comprehensive Metabolic Profiling Of high MYC Medulloblastoma Reveals Key Differences Between In Vitro And In Vivo Glucose And Glutamine Usage

Autor: Charles G. Eberhart, Heather Sweeney, Rana Rais, Khoa Pham, Akhila Parthasarathy, Brad Poore, Barbara S. Slusher, Jesse Alt, Micah J. Maxwell, Allison Hanaford, Eric H. Raabe

Publikováno v: Neuro-oncology Advances

Reprograming of cellular metabolism is a hallmark of cancer. The metabolic alterations in cancer cells is not only defined by series of genetic mutations, but also reflecting the crosstalk between cancer cells and other factors in the microenvironmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9ee13a3ddbf8731c089fdeae187edff
http://europepmc.org/articles/PMC8255443

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FSMP-18. COMPREHENSIVE METABOLIC PROFILING OF HIGH MYC MEDULLOBLASTOMA REVEALS KEY DIFFERENCES BETWEEN IN VITRO AND IN VIVO GLUCOSE AND GLUTAMINE USAGE

Autor: Khoa Pham, Brad Poore, Allison Hanaford, Micah J Maxwell, Heather Sweeney, Akhila Parthasarathy, Jesse Alt, Rana Rais, Barbara S Slusher, Charles G Eberhart, Eric H Raabe

Publikováno v: Neuro-oncology Advances

Reprograming of cellular metabolism is a hallmark of cancer. Altered metabolism can overcome unfavorable conditions, allowing cancer cells to proliferate and invade in different tumor microenvironments. Medulloblastoma is the most common malignant br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd15e5af1bfa8db206d0db92dc5a0a90
http://europepmc.org/articles/PMC7992222

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