Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Micah J. Benson"'
Autor:
Katri Sofjan, Sharon Lin, Sol Shenker, Caroline Dugopolski, Leila Williams, Karrie Wong, Christopher Wrocklage, Mallory Brady, Hugh S. Gannon, Frank Stegmeier, Robert A. LaMothe, Tracy VandenBerg, Noah Tubo, Micah J. Benson, Tianlei Xu, Nicholas John Colletti, Michael R. Schlabach, Louise Cadzow
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundAdoptive cell therapy with ex vivo expanded tumor infiltrating lymphocytes (TIL) offers a potentially curative treatment for cancer. However, the immunosuppressive tumor microenvironment limits the effectiveness of TIL therapy. To address t
Autor:
Conor Calnan, Michael R. Schlabach, Sharon Lin, Louise Cadzow, Sol Shenker, Frank Stegmeier, Katri Sofjan, Karrie Wong, Isabelle Le Mercier, Anja Hohmann, Gregory Kryukov, Micah J. Benson, Christopher Wrocklage, Leila Williams, Caroline Bullock
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A215-A215
BackgroundThe application of CRISPR/Cas9-gene-editing to enhance the anti-tumor activity of T cell Adoptive Cell Therapies (ACT) is a promising approach in the treatment of patients with solid tumors. We developed an in vivo CRISPR^2 screening approa
Autor:
Conor Calnan, Chris Wrocklage, Rami Rahal, Nick Colletti, Jason Merkin, Sol Shenker, Caroline Bullock, Matt Noyes, Anja Hohmann, Louise Cadzow, Noah Tubo, Frank Stegmeier, Sean P. Arlauckas, Sean Keegan, Aria Pearlman Morales, Gregory Kryukov, Micah J. Benson, Mike Schlabach, Eric Fagerberg, Isabelle Le Mercier, Tianlei Xu
Publikováno v:
Molecular Cancer Therapeutics. 18:C101-C101
Although immunotherapy with PD-1/PD-L1 antagonists has significantly advanced patient care, the majority of cancer patients currently do not benefit from checkpoint inhibitor therapies. To identify novel targets for the treatment of PD-1 insensitive
Autor:
Cheryl Nickerson-Nutter, Dean Messing, Nilufer P. Seth, Sean Keegan, John Douhan, Jason Edmonds, Timothy A. Cook, Stephen E. Benoit, Andrew L. Rankin, Varenka Rodriguez, Sarah Du, Micah J. Benson, Melanie Ruzek, Mark E. Schnute, Kyri Dunussi-Joannopoulos, David von Schack
Publikováno v:
The Journal of Immunology. 193:185-197
Inhibitors of Bruton’s tyrosine kinase (BTK) possess much promise for the treatment of oncologic and autoimmune indications. However, our current knowledge of the role of BTK in immune competence has been gathered in the context of genetic inactiva
Autor:
Bruce L. Homer, Shashi K. Ramaiah, Sean Keegan, Cheryl Nickerson-Nutter, Joy S. Miyashiro, Stephen E. Benoit, Tatyana Andreyeva, Jameel Syed, Nagappan Mathialagan, Shashi Mohan, Nancy L. Wood, Jason Edmonds, Mark E. Schnute, Andrew L. Rankin, Elena Peeva, Yutian Zhan, Kyri Dunussi-Joannopoulos, Dean Messing, Timothy A. Cook, Micah J. Benson, John Douhan, Nilufer P. Seth
Publikováno v:
The Journal of Immunology. 191:4540-4550
Autoantibody production and immune complex deposition within the kidney promote renal disease in patients with lupus nephritis. Thus, therapeutics that inhibit these pathways may be efficacious in the treatment of systemic lupus erythematosus. Bruton
Autor:
Randolph J. Noelle, Michael J. Molloy, William L. Schpero, Edward J. Usherwood, Micah J. Benson, Weijun Zhang, Raul Elgueta
Publikováno v:
Benson, M J, Elgueta, R, Schpero, W, Molloy, M, Zhang, W, Usherwood, E & Noelle, R J 2009, ' Distinction of the memory B cell response to cognate antigen versus bystander inflammatory signals ', The Journal of experimental medicine, vol. 206, no. 9, pp. 2013-25 . https://doi.org/10.1084/jem.20090667
The Journal of Experimental Medicine
The Journal of Experimental Medicine
The hypothesis that bystander inflammatory signals promote memory B cell (B(MEM)) self-renewal and differentiation in an antigen-independent manner is critically evaluated herein. To comprehensively address this hypothesis, a detailed analysis is pre
Publikováno v:
Annals of the New York Academy of Sciences. 1143:170-187
On occasion, emerging scientific fields intersect and great discoveries result. In the last decade, the discovery of regulatory T cells (T(reg)) in immunity has revolutionized our understanding of how the immune system is controlled. Intersecting the
Autor:
Emanuela Castigli, Stacey R. Dillon, Raif S. Geha, Micah J. Benson, Shengli Xu, Randolph J. Noelle, Kong-Peng Lam
Publikováno v:
The Journal of Immunology. 180:3655-3659
Memory B (BMEM) cells and long-lived bone marrow plasma cells (BM-PCs) persist within local environmental survival niches that afford cellular longevity. However, the factors supporting BMEM cell survival within the secondary lymphoid organs and allo
Publikováno v:
Journal of Experimental Medicine. 204:1765-1774
We demonstrate that all-trans retinoic acid (RA) induces FoxP3+ adaptive T regulatory cells (A-Tregs) to acquire a gut-homing phenotype (α4β7+ CC chemokine receptor 9+) and the capacity to home to the lamina propria of the small intestine. Under co
Publikováno v:
Immunology Letters. 109:93-100
Long-term humoral immunity elicited by pathogens and vaccines alike relies upon the generation of both memory B cells (B mem ) and long-lived plasma cells (PCs). Virtually all vaccine formulations induce the concomitant emergence of both B mem and PC