Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Micaela Tatman"'
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Abstract Missense mutations in UBQLN2 cause X-linked dominant inheritance of amyotrophic lateral sclerosis with frontotemporal dementia (ALS/FTD). UBQLN2 belongs to a family of four highly homologous proteins expressed in humans that play diverse rol
Externí odkaz:
https://doaj.org/article/0fcaba42c1b74b49bb6f46fc339a3d9e
Publikováno v:
Biochimica et biophysica acta. General subjects. 1867(2)
Here we present evidence, based on alterations of its intrinsic tryptophan fluorescence, that UBQLN2 protein undergoes a conformational switch when the temperature is raised from 37 °C to 42 °C. The switch is reset on restoration of the temperature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54aa8212bdba8975b0f0f45af5d32fec
https://pubmed.ncbi.nlm.nih.gov/36423739
https://pubmed.ncbi.nlm.nih.gov/36423739
Autor:
Ashley Cai, Richard L.M. Faull, Maurice A. Curtis, Daniel Finley, Nicole R. Higgins, Josephine J. Wu, Emma L. Scotter, Cong Fan, Mervyn J. Monteiro, Miguel A. Prado, Christopher Shaw, Jessie E. Greenslade, Alexandra M. Whiteley, Teepu Siddique, Micaela Tatman, Birger Dieriks, Nhat T. T. Le
Publikováno v:
Proceedings of the National Academy of Sciences. 117:15230-15241
Mutations in UBQLN2 cause amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neurodegenerations. However, the mechanism by which the UBQLN2 mutations cause disease remains unclear. Alterations in proteins involved in autoph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f41f9f51298f0160dfb7a4add9eb99fc
https://doi.org/10.1073/pnas.1917371117
https://doi.org/10.1073/pnas.1917371117