Výsledky vyhledávání - "Micaela Polay Espinoza"

Akademický článek

Immortalized human myotonic dystrophy muscle cell lines to assess therapeutic compounds

Autor: Ludovic Arandel, Micaela Polay Espinoza, Magdalena Matloka, Audrey Bazinet, Damily De Dea Diniz, Naïra Naouar, Frédérique Rau, Arnaud Jollet, Frédérique Edom-Vovard, Kamel Mamchaoui, Mark Tarnopolsky, Jack Puymirat, Christophe Battail, Anne Boland, Jean-Francois Deleuze, Vincent Mouly, Arnaud F. Klein, Denis Furling

Publikováno v: Disease Models & Mechanisms, Vol 10, Iss 4, Pp 487-497 (2017)

Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are autosomal dominant neuromuscular diseases caused by microsatellite expansions and belong to the family of RNA-dominant disorders. Availability of cellular models in which the DM mutation is express

Externí odkaz: https://doaj.org/article/24e28eed0b544967b621a599b1213dac

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Akademický článek

RNA Helicases DDX5 and DDX17 Dynamically Orchestrate Transcription, miRNA, and Splicing Programs in Cell Differentiation

Autor: Etienne Dardenne, Micaela Polay Espinoza, Laurent Fattet, Sophie Germann, Marie-Pierre Lambert, Helen Neil, Eleonora Zonta, Hussein Mortada, Lise Gratadou, Mathieu Deygas, Fatima Zahra Chakrama, Samaan Samaan, François-Olivier Desmet, Léon-Charles Tranchevent, Martin Dutertre, Ruth Rimokh, Cyril F. Bourgeois, Didier Auboeuf

Publikováno v: Cell Reports, Vol 7, Iss 6, Pp 1900-1913 (2014)

The RNA helicases DDX5 and DDX17 are members of a large family of highly conserved proteins that are involved in gene-expression regulation; however, their in vivo targets and activities in biological processes such as cell differentiation, which req

Externí odkaz: https://doaj.org/article/f41175769b504840ba9574c06d5714fb

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Reversal of RNA toxicity in myotonic dystrophy via a decoy RNA-binding protein with high affinity for expanded CUG repeats

Publikováno v: Nature Biomedical Engineering
Nature Biomedical Engineering, 2022, 6 (2), pp.207-220. ⟨10.1038/s41551-021-00838-2⟩

Myotonic dystrophy type 1 (DM1) is an RNA-dominant disease whose pathogenesis stems from the functional loss of muscleblind-like RNA-binding proteins (RBPs), which causes the formation of alternative-splicing defects. The loss of functional musclebli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47afebbac1a3f5f463cf2e7f19be5d6
https://hal.science/hal-03830811/document

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Translational reprogramming of colorectal cancer cells induced by 5-fluorouracil through a miRNA-dependent mechanism

Autor: Frédéric Catez, Hichem C. Mertani, Françoise Macari, Micaela Polay Espinoza, Nathalie Pion, Gabriel Therizols, Florian Laforêts, Alexandre David, Martin Dutertre, Julien Textoris, Zeina Bash-Imam, Anne Vincent, Nicole Dalla Venezia, Julie Pannequin, Didier Auboeuf, Jean-Jacques Diaz, Jean-Christophe Saurin, Virginie Marcel

Publikováno v: Oncotarget
Oncotarget, Impact journals, 2017, 8 (28), pp.46219-46233. ⟨10.18632/oncotarget.17597⟩

// Zeina Bash-Imam 1 * , Gabriel Therizols 1 * , Anne Vincent 1 , Florian Laforets 1 , Micaela Polay Espinoza 1 , Nathalie Pion 1 , Francoise Macari 4 , Julie Pannequin 4 , Alexandre David 4 , Jean-Christophe Saurin 1 , Hichem C. Mertani 1 , Julien T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c91506c4f4f6cbf5057112ab69c2b2
https://hal.archives-ouvertes.fr/hal-03079241/document

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RNA Helicases DDX5 and DDX17 Dynamically Orchestrate Transcription, miRNA, and Splicing Programs in Cell Differentiation

Autor: Hussein Mortada, Lise Gratadou, Ruth Rimokh, Mathieu Deygas, Didier Auboeuf, Cyril F. Bourgeois, Samaan Samaan, Helen Neil, Eleonora Zonta, Micaela Polay Espinoza, Laurent Fattet, Fatima Zahra Chakrama, Martin Dutertre, Sophie Germann, François-Olivier Desmet, Marie-Pierre Lambert, Etienne Dardenne, Léon-Charles Tranchevent

Publikováno v: Cell Reports, Vol 7, Iss 6, Pp 1900-1913 (2014)

SummaryThe RNA helicases DDX5 and DDX17 are members of a large family of highly conserved proteins that are involved in gene-expression regulation; however, their in vivo targets and activities in biological processes such as cell differentiation, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6abe1c7cea58d2e451fc7d6062172b

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Endothelial, epithelial, and fibroblast cells exhibit specific splicing programs independently of their tissue of origin

Autor: Samaan Samaan, Léon-Charles Tranchevent, Jean-Philippe Villemin, Emilie Chautard, Pierre Mallinjoud, Didier Auboeuf, Hussein Mortada, Micaela Polay Espinoza, François-Olivier Desmet

Publikováno v: Genome Research
Genome Research, 2014, 24 (3), pp.511-521. ⟨10.1101/gr.162933.113⟩
Genome Research, Cold Spring Harbor Laboratory Press, 2014, 24 (3), pp.511-521. ⟨10.1101/gr.162933.113⟩

International audience; Alternative splicing is the main mechanism of increasing the proteome diversity coded by a limited number of genes. It is well established that different tissues or organs express different splicing variants. However, organs a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb0c1bdbd3563e1fa2abf706e315059
https://doi.org/10.1101/gr.162933.113

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The Ddx5 and Ddx17 RNA helicases are cornerstones in the complex regulatory array of steroid hormone-signaling pathways

Autor: Léon-Charles Tranchevent, Lise Gratadou, Etienne Dardenne, Didier Auboeuf, Sophie Germann, Micaela Polay Espinoza, Samaan Samaan, Eleonora Zonta, Martin Dutertre

Publikováno v: Nucleic Acids Research

Estrogen and androgen receptors (ER and AR) play key roles in breast and prostate cancers, respectively, where they regulate the transcription of large arrays of genes. The activities of ER and AR are controlled by large networks of protein kinases a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34f1b67fc8d7d4203dedfaf204223f3
https://doi.org/10.1093/nar/gkt1216

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A recently evolved class of alternative 3′-terminal exons involved in cell cycle regulation by topoisomerase inhibitors

Autor: Hussein Mortada, François-Olivier Desmet, Lise Gratadou, Fatima Zahra Chakrama, Didier Auboeuf, Emmanuel Combe, Martin Dutertre, Micaela Polay Espinoza

Publikováno v: Nature Communications. 5

Alternative 3'-terminal exons, which use intronic polyadenylation sites, are generally less conserved and expressed at lower levels than the last exon of genes. Here we discover a class of human genes, in which the last exon appeared recently during

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7039bbf579a40eb043606b6e399fa468
https://doi.org/10.1038/ncomms4395

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Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness

Autor: Lise Gratadou, Stéphan Vagner, Rosette Lidereau, Sophie Germann, Keltouma Driouch, Magali Lacroix-Triki, Didier Auboeuf, Jean-Philippe Villemin, Etienne Dardenne, Martin Dutertre, Sandra Pierredon, Eleonora Zonta, Micaela Polay Espinoza, Hussein Mortada

Publikováno v: Nature structuralmolecular biology. 19(11)

Both epigenetic and splicing regulation contribute to tumor progression, but the potential links between these two levels of gene-expression regulation in pathogenesis are not well understood. Here, we report that the mouse and human RNA helicases Dd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7437f552b2a53522e10ebf9ec7ffae7
https://pubmed.ncbi.nlm.nih.gov/23076160

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