Zobrazeno 1 - 10
of 1 086
pro vyhledávání: '"Micaela, Morelli"'
Autor:
Anna Di Maio, Tommaso Nuzzo, Luana Gilio, Marcello Serra, Fabio Buttari, Francesco Errico, Arianna De Rosa, Mario Stampanoni Bassi, Micaela Morelli, Jumpei Sasabe, David Sulzer, Manolo Carta, Diego Centonze, Alessandro Usiello
Publikováno v:
Neurobiology of Disease, Vol 184, Iss , Pp 106203- (2023)
L-serine generated in astrocytes plays a pivotal role in modulating essential neurometabolic processes, while its enantiomer, D-serine, specifically regulates NMDA receptor (NMDAR) signalling. Despite their physiological relevance in modulating cereb
Externí odkaz:
https://doaj.org/article/e7518a3495a0499ea6ecba49a65a421f
Autor:
Marcello Serra, Anna Di Maio, Valentina Bassareo, Tommaso Nuzzo, Francesco Errico, Federica Servillo, Mario Capasso, Pathik Parekh, Qin Li, Marie-Laure Thiolat, Erwan Bezard, Paolo Calabresi, David Sulzer, Manolo Carta, Micaela Morelli, Alessandro Usiello
Publikováno v:
Neurobiology of Disease, Vol 184, Iss , Pp 106226- (2023)
Loss of dopaminergic midbrain neurons perturbs l-serine and d-serine homeostasis in the post-mortem caudate putamen (CPu) of Parkinson's disease (PD) patients. However, it is unclear whether the severity of dopaminergic nigrostriatal degeneration pla
Externí odkaz:
https://doaj.org/article/32f6acc0b6824302a2510d94ba1684ce
Autor:
Giulia Costa, Marcello Serra, Riccardo Maccioni, Maria Antonietta Casu, Sanjay B. Kasture, Elio Acquas, Micaela Morelli
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 161, Iss , Pp 114475- (2023)
Withania somnifera (WS) is utilized in Ayurvedic medicine owing to its central and peripheral beneficial properties. Several studies have accrued indicating that the recreational amphetamine-related drug (+/-)− 3,4-methylenedioxymethamphetamine (MD
Externí odkaz:
https://doaj.org/article/aa97299aebb54de28b7f96ef8dd2edf6
Autor:
Ermanno Florio, Marcello Serra, Robert G. Lewis, Enikö Kramár, Michael Freidberg, Marcello Wood, Micaela Morelli, Emiliana Borrelli
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105263- (2022)
Summary: Degeneration of dopaminergic neurons leads to Parkinson’s disease (PD), characterized by reduced levels of striatal dopamine (DA) and impaired voluntary movements. DA replacement is achieved by levodopa treatment which in long-term causes
Externí odkaz:
https://doaj.org/article/e6de8d72e2b24bc7b5d341bb345751d3
Autor:
Pathik Parekh, Marcello Serra, Mohamad Allaw, Matteo Perra, Jacopo Marongiu, Giulia Tolle, Annalisa Pinna, Maria Antonietta Casu, Maria Manconi, Pierluigi Caboni, Olivier J. J. Manzoni, Micaela Morelli
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Grape pomaces have recently received great attention for their richness in polyphenols, compounds known to exert anti-inflammatory and antioxidant effects. These pomaces, however, have low brain bioavailability when administered orally due to their e
Externí odkaz:
https://doaj.org/article/8bf6459a2145424a9a291a154460a8b6
Autor:
Giulia Costa, Francesca Felicia Caputi, Marcello Serra, Nicola Simola, Laura Rullo, Serena Stamatakos, Fabrizio Sanna, Marc Germain, Maria-Grazia Martinoli, Sanzio Candeletti, Micaela Morelli, Patrizia Romualdi
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
3,4-Methylenedioxymethamphetamine (MDMA, “ecstasy”) is an amphetamine-related drug that may damage the dopaminergic nigrostriatal system. To investigate the mechanisms that sustain this toxic effect and ascertain their sex-dependence, we evaluate
Externí odkaz:
https://doaj.org/article/850895601dc247b99dd64f3b172d3987
Autor:
Sarah Vascellari, Vanessa Palmas, Marta Melis, Silvia Pisanu, Roberto Cusano, Paolo Uva, Daniela Perra, Veronica Madau, Marianna Sarchioto, Valentina Oppo, Nicola Simola, Micaela Morelli, Maria Laura Santoru, Luigi Atzori, Maurizio Melis, Giovanni Cossu, Aldo Manzin
Publikováno v:
mSystems, Vol 5, Iss 5 (2020)
ABSTRACT Parkinson’s disease is a neurodegenerative disorder characterized by the accumulation of intracellular aggregates of misfolded alpha-synuclein along the cerebral axis. Several studies report the association between intestinal dysbiosis and
Externí odkaz:
https://doaj.org/article/809869bcae4e4aafac202dd23e421b0b
Autor:
Giulia Costa, Maria Jose Sisalli, Nicola Simola, Salvatore Della Notte, Maria Antonietta Casu, Marcello Serra, Annalisa Pinna, Antonio Feliciello, Lucio Annunziato, Antonella Scorziello, Micaela Morelli
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Twelve-month-old male mice expressing the human A53T variant of α-synuclein (A53T) develop dopamine neuron degeneration, neuroinflammation, and motor deficits, along with dysfunctions of the mitochondrial Na+-Ca2+ exchanger (NCX) isoforms 1 (NCX1) a
Externí odkaz:
https://doaj.org/article/b267c94e14ff42a9b21368aec1e21506
Autor:
Antonella Scorziello, Domenica Borzacchiello, Maria Jose Sisalli, Rossana Di Martino, Micaela Morelli, Antonio Feliciello
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
The loss of dopaminergic (DA) neurons in the substantia nigra leads to a progressive, long-term decline of movement and other non-motor deficits. The symptoms of Parkinson’s disease (PD) often appear later in the course of the disease, when most of
Externí odkaz:
https://doaj.org/article/7256f83161f24ad8abe5e3a98fc2ad1a
Autor:
Sarah Vascellari, Marta Melis, Vanessa Palmas, Silvia Pisanu, Alessandra Serra, Daniela Perra, Maria Laura Santoru, Valentina Oppo, Roberto Cusano, Paolo Uva, Luigi Atzori, Micaela Morelli, Giovanni Cossu, Aldo Manzin
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 144 (2021)
Parkinson’s disease (PD) is a clinically heterogenic disorder characterized by distinct clinical entities. Most studies on motor deficits dichotomize PD into tremor dominant (TD) or non-tremor dominant (non-TD) with akinetic-rigid features (AR). Di
Externí odkaz:
https://doaj.org/article/27c8cac0297b445989eb71c5ebf088cc