Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Micael Rodrigues Cunha"'
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Akademický článek
Peppers: A 'Hot' Natural Source for Antitumor Compounds
Autor: Micael Rodrigues Cunha, Maurício Temotheo Tavares, Thais Batista Fernandes, Roberto Parise-Filho
Publikováno v: Molecules, Vol 26, Iss 6, p 1521 (2021)
Piper, Capsicum, and Pimenta are the main genera of peppers consumed worldwide. The traditional use of peppers by either ancient civilizations or modern societies has raised interest in their biological applications, including cytotoxic and antiproli
Externí odkaz: https://doaj.org/article/a72d8e63def04251883a34134e3d7100
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2
Akademický článek
Multi-Spectroscopic and Theoretical Analysis on the Interaction between Human Serum Albumin and a Capsaicin Derivative—RPF101
Autor: Otávio Augusto Chaves, Maurício Temotheo Tavares, Micael Rodrigues Cunha, Roberto Parise-Filho, Carlos Maurício R. Sant’Anna, José Carlos Netto-Ferreira
Publikováno v: Biomolecules, Vol 8, Iss 3, p 78 (2018)
The interaction between the main carrier of endogenous and exogenous compounds in the human bloodstream (human serum albumin, HSA) and a potential anticancer compound (the capsaicin analogue RPF101) was investigated by spectroscopic techniques (circu
Externí odkaz: https://doaj.org/article/d7489665ccd44e9988256e2aad039f86
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3
Natural product inspired optimization of a selective TRPV6 calcium channel inhibitor† †Electronic supplementary information (ESI) available: Tables S1–S3, Fig. S1–S4, protocols for FLIPR assays, confocal imaging and antiproliferative assays, preparation, crystal structure reports, HRMS results, 1H, 13C and 19F NMR spectra of all new compounds, and purity of final compounds. CCDC 1997201–1997205. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/d0md00145g
Autor: Rajesh Bhardwaj, Christoph Romanin, Jean-Louis Reymond, Aline Lucie Carrel, Roberto Parise-Filho, Micael Rodrigues Cunha, Matthias A. Hediger, Sonja Lindinger
Publikováno v: RSC Medicinal Chemistry
Rodrigues Cunha, Micael; Bhardwaj, Rajesh; Carrel, Aline Lucie; Lindinger, Sonja; Romanin, Christoph; Parise-Filho, Roberto; Hediger, Matthias A.; Reymond, Jean-Louis (2020). Natural product inspired optimization of a selective TRPV6 calcium channel inhibitor. RSC Medicinal Chemistry, 11(9), pp. 1032-1040. Royal Society of Chemistry 10.1039/D0MD00145G
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Natural product derived analogues were surveyed, and an oxygenated analog was identified as a potent and selective TRPV6 inhibitor, with high microsomal stability and low off-target effects.
Transient receptor potential vanilloid 6 (TRPV6) is a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f6e7af45859faee2026335ad3529ed
http://europepmc.org/articles/PMC7513592
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4
Inactivation-mimicking block of the epithelial calcium channel TRPV6
Autor: Matthias A. Hediger, Rajesh Bhardwaj, Micael Rodrigues Cunha, Appu K. Singh, Jean-Louis Reymond, Isabella Derler, Sonja Lindinger, Christoph Romanin, Arthur Neuberger, Gergely Gyimesi, Kirill D. Nadezhdin, Alexander I. Sobolevsky
Publikováno v: Bhardwaj, Rajesh; Lindinger, Sonja; Neuberger, Arthur; Nadezhdin, Kirill D.; Singh, Appu K.; R. Cunha, Micael; Derler, Isabella; Gyimesi, Gergely; Reymond, Jean-Louis; Hediger, Matthias A.; Romanin, Christoph; Sobolevsky, Alexander I. (2020). Inactivation-mimicking block of the epithelial calcium channel TRPV6. Science Advances, 6(48), eabe1508. American Association for the Advancement of Science 10.1126/sciadv.abe1508
Science Advances
Small-molecule piperazine derivatives mimic inactivation by calmodulin to selectively and potently block TRPV6 channels.
Epithelial calcium channel TRPV6 plays vital roles in calcium homeostasis, and its dysregulation is implicated in multifacto
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30d7e52314d72946e9969bc4475962c
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6
Targeting the hTRPV6 with capsaicinoid inhibitors
Autor: Micael Rodrigues Cunha
Publikováno v: Biblioteca Digital de Teses e Dissertações da USP
Universidade de São Paulo (USP)
instacron:USP
Capsaicin is a substance produced by Capsicum peppers with extensive biological activity reported in the literature. Among these studies, it was suggested that the anti-tumor activity is related to modulation of the Transient Potential Receptor Vanil
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::3b1017c91119ca72b0a87bdc1919e3a9
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7
Capsaicin-like analogue induced selective apoptosis in A2058 melanoma cells: Design, synthesis and molecular modeling
Autor: Barbara Behr Martins, Maurício Temotheo Tavares, Rajesh Bhardwaj, Vanessa Zambelli, Euzébio Guimarães Barbosa, Micael Rodrigues Cunha, Roberto Parise-Filho, Ricardo A. Azevedo, Yara Cury, Gustavo José Vasco Pereira, Matthias A. Hediger
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
The use of molecules inspired by natural scaffolds has proven to be a very promising and efficient method of drug discovery. In this work, capsaicin, a natural product from Capsicum peppers with antitumor properties, was used as a prototype to obtain
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9077d7ef84efdb06f49f6c554d036728
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8
Photoswitchable Inhibitor of the Calcium Channel TRPV6
Autor: Rajesh Bhardwaj, Jean-Louis Reymond, Matthias A. Hediger, Christoph Romanin, Carmen Butorac, Micael Rodrigues Cunha, Sonja Lindinger
Publikováno v: ACS Med Chem Lett
[Image: see text] Herein we report the first photoswitchable inhibitor of Transient Receptor Potential Vanilloid 6 (TRPV6), a selective calcium channel involved in a number of diseases and in cancer progression. By surveying analogs of a previously r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68698cae50bd1c86eb9ddb7009b96282
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9
Analgesic activity of Ruta graveolens L. (Rue) extracts
Autor: Fátima Maria Motter Magri, Micael Rodrigues Cunha, Tahira Souza Melo, J. C. Delorenzi
Publikováno v: African Journal of Pharmacy and Pharmacology. 9:1-5
The knowledge of pharmacological activity is mainly derived from the use that the population makes of plants. Rue (Ruta graveolens L.) is popularly used with a degree of mysticism due to its anti-inflammatory, healing, sedative and antispasmodic char
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4372f1bbd3d0004d5080621670f55e8
https://doi.org/10.5897/ajpp2014.4152
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10
Using an in silico approach to teach 3D pharmacodynamics of the drug-target interaction process focusing on selective COX2 inhibition by celecoxib
Autor: Marina Candido Primi, Roberto Parise-Filho, Micael Rodrigues Cunha, Maurício Temotheo Tavares, Camila Felix de Carvalho, Nuno Albuquerque Tavares Ferreira da Silva
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Teaching the molecular aspects of drug–target interactions and selectivity is not always an easy task. In this context, the use of alternative and engaging approaches could help pharmacy and chemistry students better understand this important topic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32439ee4bbcfb97e2b597ff9bebe3ae2
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