Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Miaorong Yu"'
Autor:
Jie Wang, Zilong Zhang, Yan Zhuo, Zhuan Zhang, Rongrong Chen, Li Liang, Xiaohe Jiang, Di Nie, Chang Liu, Zhiwen Zou, Xiang Li, Jiaxin Li, Bingqi Wang, Rui Wang, Yong Gan, Miaorong Yu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 8, Pp 3643-3660 (2024)
The prospect of employing chemoimmunotherapy targeted towards the endoplasmic reticulum (ER) presents an opportunity to amplify the synergistic effects of chemotherapy and immunotherapy. In this study, we initially validated celastrol (CEL) as an ind
Externí odkaz:
https://doaj.org/article/8cd666c37ea84775a898da7c02d10cf7
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 5, Pp 2006-2025 (2024)
Diabetes, characterized by hyperglycemia, is a major cause of death and disability worldwide. Peptides, such as insulin and glucagon-like peptide-1 (GLP-1) analogs, have shown promise as treatments for diabetes due to their ability to mimic or enhanc
Externí odkaz:
https://doaj.org/article/a64e07b44a04486b913f00ceed99624b
Yolk-shell cationic liposomes overcome mucus and epithelial barriers for enhanced oral drug delivery
Autor:
Yu Qiu, Yan Zhuo, Yangyuan Ye, Xiang Li, Zhu Zhu, Bingqi Wang, Cong Guo, Yuan Liu, Miaorong Yu
Publikováno v:
Giant, Vol 17, Iss , Pp 100221- (2024)
Liposomes have garnered attention for their potential in oral drug delivery. However, they encounter obstacles when traversing the mucus and epithelial barriers of the gastrointestinal tract. Recent studies indicate that the very characteristics enab
Externí odkaz:
https://doaj.org/article/9e539d9499f04f65a0e2944c41910269
Autor:
Tiantian Yang, Aohua Wang, Di Nie, Weiwei Fan, Xiaohe Jiang, Miaorong Yu, Shiyan Guo, Chunliu Zhu, Gang Wei, Yong Gan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Displaying the correct surface functionality at the right time is important for efficient drug delivery. Here, the authors report on the pH-responsive, sequential presentation of cell-penetrating peptide and liver-targeting moiety designed to improve
Externí odkaz:
https://doaj.org/article/3d81ccdc25f54a5892122f0eaf3dad1a
Autor:
Jingyi Li, Yaqi Zhang, Miaorong Yu, Aohua Wang, Yu Qiu, Weiwei Fan, Lars Hovgaard, Mingshi Yang, Yiming Li, Rui Wang, Xiuying Li, Yong Gan
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 3, Pp 1460-1472 (2022)
Transporters are traditionally considered to transport small molecules rather than large-sized nanoparticles due to their small pores. In this study, we demonstrate that the upregulated intestinal transporter (PCFT), which reaches a maximum of 12.3-f
Externí odkaz:
https://doaj.org/article/98219f5a36ae4da8af469622a2e64706
Publikováno v:
Medicine in Drug Discovery, Vol 12, Iss , Pp 100110- (2021)
Mucus is a viscoelastic hydrogel that lubricates and protects mucosal tissues such as the eyes, lung, gastrointestinal tract, and vagina. Nanoparticle-based drug delivery systems (DDSs) can be easily trapped in the mucus network by steric obstruction
Externí odkaz:
https://doaj.org/article/e211f9c5a04e4731a75b512b039d03e8
Autor:
Hangyi Wu, Miaorong Yu, Yunqiu Miao, Shufang He, Zhuo Dai, Wenyi Song, Yuan Liu, Sha Song, Ejaj Ahmad, Dongkai Wang, Yong Gan
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 4, Pp 858-870 (2019)
Recently, liposomes have been widely used in cancer therapeutics, but their anti-tumor effects are suboptimal due to limited tumor penetration. To solve this problem, researchers have made significant efforts to optimize liposomal diameters and poten
Externí odkaz:
https://doaj.org/article/e6550032e72d474fac379d33bfc3ea99
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 1, Pp 107-117 (2019)
Increasing the degree of supersaturation of drugs and maintaining their proper stability are very important in improving the oral bioavailability of poorly soluble drugs by a supersaturated drug delivery system (SDDS). In this study, we reported a co
Externí odkaz:
https://doaj.org/article/7d323cb095c54f6d85d114b74457000f
Autor:
Yan Wei, Sha Song, Nianxiu Duan, Feng Wang, Yuxi Wang, Yiwei Yang, Chengyuan Peng, Junjun Li, Di Nie, Xinxin Zhang, Shiyan Guo, Chunliu Zhu, Miaorong Yu, Yong Gan
Publikováno v:
Advanced Science, Vol 7, Iss 17, Pp n/a-n/a (2020)
Abstract Promoting tumor angiogenesis effectively and specifically to resolve tumor‐associated hypoperfusion holds promise for improving pancreatic cancer therapy. Herein, a doxorubicin (DOX) loaded smart liposome, MC‐T‐DOX, is constructed, tha
Externí odkaz:
https://doaj.org/article/a21c09fafa2349c7a6b2f63686294cdd
Rapid transport of deformation-tuned nanoparticles across biological hydrogels and cellular barriers
Autor:
Miaorong Yu, Lu Xu, Falin Tian, Qian Su, Nan Zheng, Yiwei Yang, Jiuling Wang, Aohua Wang, Chunliu Zhu, Shiyan Guo, XinXin Zhang, Yong Gan, Xinghua Shi, Huajian Gao
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Penetration of the mucus and tumor interstitial matrix is an important consideration for drug delivery devices. Here, the authors report on a study into the optimization of rigidity for the transport of nanoparticles through biological hydrogels usin
Externí odkaz:
https://doaj.org/article/62b09f2339fb4640a540c588e511272e