Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Miaojin Zhou"'
Autor:
Yuxuan Zhang, Qingxin Shi, Peiyun Wang, Chujun Huang, Shuqing Tang, Miaojin Zhou, Qian Hu, Lingqian Wu, Desheng Liang
Publikováno v:
MedComm, Vol 5, Iss 5, Pp n/a-n/a (2024)
Abstract The generation of chimeric antigen receptor‐modified natural killer (CAR‐NK) cells using induced pluripotent stem cells (iPSCs) has emerged as one of the paradigms for manufacturing off‐the‐shelf universal immunotherapy. However, the
Externí odkaz:
https://doaj.org/article/584e85594ecc4e48a7f048539558fbb7
Autor:
Hanzhe Kuang, Yunlong Li, Yixuan Wang, Meizhen Shi, Ranhui Duan, Qiao Xiao, Haoyuan She, Yingdi Liu, Qiaowei Liang, Yanling Teng, Miaojin Zhou, Desheng Liang, Zhuo Li, Lingqian Wu
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113445- (2023)
Summary: The INTS11 endonuclease is crucial in modulating gene expression and has only recently been linked to human neurodevelopmental disorders (NDDs). However, how INTS11 participates in human development and disease remains unclear. Here, we iden
Externí odkaz:
https://doaj.org/article/99137d83bbf747d8a0d8c85994c6ba90
Autor:
Miaojin Zhou, Chunhua Zhang, Miaomiao Chen, Zhiqing Hu, Menglin Li, Zhuo Li, Lingqian Wu, Desheng Liang
Publikováno v:
MedComm, Vol 4, Iss 4, Pp n/a-n/a (2023)
Abstract Clustered regularly interspaced short palindromic repeat (CRISPR)‐based biosensors have been developed to facilitate the rapid and sensitive detection of nucleic acids. However, most approaches using CRISPR‐based detection have disadvant
Externí odkaz:
https://doaj.org/article/087db16c417e4d0db4f6b52e1ff8360f
Autor:
Zhiqing Hu, Yong Wu, Rou Xiao, Junya Zhao, Yan Chen, Lingqian Wu, Miaojin Zhou, Desheng Liang
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Introduction: Hemophilia A (HA) is the most common genetic bleeding disorder caused by mutations in the F8 gene encoding coagulation factor VIII (FVIII). As the second predominant pathogenic mutation in hemophilia A severe patients, F8 Intron one inv
Externí odkaz:
https://doaj.org/article/c661de3703ae4fd282b5bbe3040bb26d
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/a39a9946e46f438fbfc22cf898b03eab
Autor:
Qian Hu, Yuxuan Zhang, Peiyun Wang, Miaojin Zhou, Zhiqing Hu, Cong Liu, Mujun Liu, Lingqian Wu, Xionghao Liu, Desheng Liang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/8691a1b041394aeb880b005c2fe6cd24
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 17, Iss , Pp 198-209 (2019)
Given that the cDNA of F8 is too large to be packaged into adeno-associated virus (AAV) capsids, gene transfer of some versions of B-domain-deleted F8 (BDD-F8) for hemophilia A (HA) treatment has been attempted with promising results. Here, we descri
Externí odkaz:
https://doaj.org/article/aad2b4c7570a48bea9e4449e4d5f5b66
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Hemophilia A (HA), an X-linked recessive congenital bleeding disorder, affects 80%–85% of patients with hemophilia. Nearly half of severe cases of hemophilia are caused by a 0.6-Mb genomic inversion (Inv22) that disrupts F8. Although viral-based ge
Externí odkaz:
https://doaj.org/article/93511d640c77423f93037c0412588808
Autor:
Zhiqing Hu, Miaomiao Chen, Chunhua Zhang, Zhuo Li, Mai Feng, Lingqian Wu, Miaojin Zhou, Desheng Liang
Publikováno v:
Biosensors, Vol 12, Iss 5, p 268 (2022)
Spinal muscular atrophy (SMA) is the main genetic cause of infant death. In >95% of the patients with SMA, the disease is caused by a single hotspot pathogenic mutation: homozygous deletion of exon 7 of the survival motor neuron 1 gene (SMN1). Recent
Externí odkaz:
https://doaj.org/article/9c3d49e021b04c7e9e151b2df2446bca
Autor:
Nannan Duan, Shuqing Tang, Baitao Zeng, Zhiqing Hu, Qian Hu, Lingqian Wu, Miaojin Zhou, Desheng Liang
Publikováno v:
Life, Vol 11, Iss 11, p 1262 (2021)
(1) Background: Gene editing technology, as represented by CRISPR is a powerful tool used in biomedical science. However, the editing efficiency of such technologies, especially in induced pluripotent stem cells (iPSCs) and other types of stem cells,
Externí odkaz:
https://doaj.org/article/4484a438e67a4695b4475dc04efca9c6