Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Miao-hsueh Chen"'
Autor:
Yong Han, Guobin Xia, Dollada Srisai, Fantao Meng, Yanlin He, Yali Ran, Yang He, Monica Farias, Giang Hoang, István Tóth, Marcelo O. Dietrich, Miao-Hsueh Chen, Yong Xu, Qi Wu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Neuronal signaling has an important role in the regulation of energy expenditure and body weight, however, the underlying mechanisms are incompletely understood. Here, the authors report a AgRP-MC4R-serotonin expressing neuronal circuit that regulate
Externí odkaz:
https://doaj.org/article/006d756f9e604f35a0e1ae19f5376f26
Publikováno v:
Cells, Vol 10, Iss 6, p 1370 (2021)
Obesity, a dysregulation of adipose tissue, is a major health risk factor associated with many diseases. Brown adipose tissue (BAT)-mediated thermogenesis can potentially regulate energy expenditure, making it an attractive therapeutic target to comb
Externí odkaz:
https://doaj.org/article/3cd6e69c59764ca7993eb23e714929d1
Publikováno v:
Cancer Research. 83:273-273
Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a mitochondrial homolog of HSP90 chaperones. It plays an important role in protection against oxidative stress and apoptosis by regulating reactive oxidative species (ROS). Recent studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e7577b3b66ab237b55cc5c839df43f0
https://doi.org/10.1158/1538-7445.am2023-273
https://doi.org/10.1158/1538-7445.am2023-273
Autor:
Qianxing Mo, Yong Gao, Makoto Fukuda, Jacqueline Naylor, Kenji Saito, Hsiaoyun Lin, Ting Yao, Kentaro Kaneko, Pingwen Xu, Elizabeth L. Cordonier, Miao Hsueh Chen, Yong Xu, Peter Ravn, Kevin W. Williams, Victor G. Howard, Yukiko Fu, Siyu S. Chen
Publikováno v:
The Journal of Clinical Investigation
Nutrient excess, a major driver of obesity, diminishes hypothalamic responses to exogenously administered leptin, a critical hormone of energy balance. Here, we aimed to identify a physiological signal that arises from excess caloric intake and negat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d73a72eadc8e492b6388fcb3b9019da
https://doi.org/10.1172/jci126107
https://doi.org/10.1172/jci126107
Autor:
István Tóth, Guobin Xia, Miao-Hsueh Chen, Giang Hoang, Monica Farias, Marcelo O. Dietrich, Dollada Srisai, Fan-Tao Meng, Yong Han, Yang He, Qi Wu, Yanlin He, Yali Ran, Yong Xu
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Contrasting to the established role of the hypothalamic agouti-related protein (AgRP) neurons in feeding regulation, the neural circuit and signaling mechanisms by which they control energy expenditure remains unclear. Here, we report that energy exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ac49c9f467c6f2f758d4c3b34cc03a9
https://doi.org/10.1038/s41467-021-23846-x
https://doi.org/10.1038/s41467-021-23846-x
Autor:
Soumyashree Das, Edward M. Bonder, Ivor Joseph, Miao-Hsueh Chen, Jiaxin Sun, Victoria Farrell, Nan Gao, Radek Dobrowolski, Qiang Feng, Ewa Stypulkowski, Juan Flores, Ryotaro Sakamori, Shiyan Yu, Sheila Bandyopadhyay
Publikováno v:
The Journal of Biological Chemistry
Differentiation of mesenchymal stem cells into adipocyte requires coordination of external stimuli and depends upon the functionality of the primary cilium. The Rab8 small GTPases are regulators of intracellular transport of membrane-bound structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0243058ab39582de4d7468c8395c32
http://europepmc.org/articles/PMC8042397
http://europepmc.org/articles/PMC8042397
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5182 (2009)
Activation of Hedgehog (Hh) signaling requires the transmembrane protein Smoothened (Smo), a member of the G-protein coupled receptor superfamily. In mammals, Smo translocates to the primary cilium upon binding of Hh ligands to their receptor, Patche
Externí odkaz:
https://doaj.org/article/47a3bf27de184793b76283b317cf6f5a
Publikováno v:
PLoS ONE. 2009, Vol. 4 Issue 4, p1-8. 8p. 4 Graphs.
Publikováno v:
Proceedings of the National Academy of Sciences. 112:5069-5074
Significance The function of brown adipose tissue (BAT), which converts chemical energy into heat, has been widely characterized, but how BAT forms and what signaling molecules regulate its formation are largely unknown. In this paper, we report that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20edc19b5ba43acfb1bc38b974c61213
https://doi.org/10.1073/pnas.1420978112
https://doi.org/10.1073/pnas.1420978112
Autor:
Lanlan Shen, Robert A. Waterland, Da-Hai Yu, Miao-Hsueh Chen, Pumin Zhang, Yongtao Guan, Manasi Gadkari, Deborah Schady
Publikováno v:
Journal of Clinical Investigation. 124:3708-3712
Cancer has long been viewed as a genetic disease; however, epigenetic silencing as the result of aberrant promoter DNA methylation is frequently associated with cancer development, suggesting an epigenetic component to the disease. Nonetheless, it ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ad69a48c6e83a23ce570f482d7158d
https://doi.org/10.1172/jci76507
https://doi.org/10.1172/jci76507