Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Miao-chong J. Lin"'
Autor:
Michael J. Lukey, Ahmad A. Cluntun, William P. Katt, Miao-chong J. Lin, Joseph E. Druso, Sekar Ramachandran, Jon W. Erickson, Henry H. Le, Zhihan-Emily Wang, Bryant Blank, Kai Su Greene, Richard A. Cerione
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 76-88.e7 (2019)
Summary: Efforts to target glutamine metabolism for cancer therapy have focused on the glutaminase isozyme GLS. The importance of the other isozyme, GLS2, in cancer has remained unclear, and it has been described as a tumor suppressor in some context
Externí odkaz:
https://doaj.org/article/febd3a642aa746e1bfa7a9c5d1e5c5be
PDF file - 136K, HRG-dependent stimulation of mTORC1-related signaling activities in SKBR3 cells is blocked by pre-treatment with the ErbB2-specific kinase inhibitor, CP-724,714. SKBR3 cells were serum-starved followed by treatment with or without 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a775737cfe725ce3f6803a56c2ae839
https://doi.org/10.1158/1541-7786.22511308
https://doi.org/10.1158/1541-7786.22511308
PDF file - 62K, Ectopically-expressed components of both mTORC1 and mTORC2 in HEK 293T cells can interact with TSC2 as well as mTOR. HEK 293T cells were transfected with either Myc-Raptor or Myc-Rictor. Cells were then lysed in lysis buffer containin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417e0e90ef92fd6a7d846abc4d875796
https://doi.org/10.1158/1541-7786.22511296
https://doi.org/10.1158/1541-7786.22511296
PDF file - 201K, HRGalpha, as well as HRGbeta, is capable of stimulating the ability of SKBR3 cells to form colonies and activate components of the mTORC1 signaling pathway. A, SKBR3 cells were seeded in 0.3% agarose-containing complete medium with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286c48b12049640bf3de7b46b5bd7592
https://doi.org/10.1158/1541-7786.22511305.v1
https://doi.org/10.1158/1541-7786.22511305.v1
PDF file - 42K, Attenuation of HRG-stimulated AKT phosphorylation by the knock-down of Rictor can be rescued by the expression of an shRNA-insensitive Rictor construct. SKBR3 cells were infected either with control or Rictor shRNA-containing virus tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::154fe4130ab33f2c63ffb163c01da763
https://doi.org/10.1158/1541-7786.22511299.v1
https://doi.org/10.1158/1541-7786.22511299.v1
PDF file - 128K, Two mechanistically-distinct mTOR inhibitors, rapamycin and INK-128, show differential abilities to inhibit signaling components upstream of mTORC1. SKBR3 cells were serum-starved for 40-48 h. Rapamycin (50 nM) or INK (50 nM) was add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e992031b657c14f70227ec7320784c3
https://doi.org/10.1158/1541-7786.22511302.v1
https://doi.org/10.1158/1541-7786.22511302.v1
Autor:
Joseph E. Druso, B. Blank, Miao-chong J. Lin, Clint A. Stalnecker, Michael J. Lukey, Robert S. Weiss, Kai Su Greene, Xueying Wang, Richard A. Cerione, Chengliang Zhang, Kristin F. Wilson, Yashira L Negrón Abril, Hening Lin, Jon W. Erickson
Publikováno v:
Proc Natl Acad Sci U S A
Significance The mitochondrial enzyme glutaminase (GLS) is frequently up-regulated in cancer cells, and a GLS-selective inhibitor is being evaluated in clinical trials. Previous screens identified succinylated lysine residues on GLS, but the function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7df8672282955596c45bf4d058b5742
https://doi.org/10.1073/pnas.1911954116
https://doi.org/10.1073/pnas.1911954116
Publikováno v:
J Biochem
Protein kinases are essential mediators of cellular signal transduction and are often dysregulated in disease. Among these, protein tyrosine kinases (PTKs) have received specific interest due to their common roles in various diseases including cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706e07eac2beb0d20c1b9c4081a891f7
https://doi.org/10.1093/jb/mvz085
https://doi.org/10.1093/jb/mvz085
Autor:
Aida Habibovic, Miao-Chong J. Lin, Jos van der Velden, Yvonne M. W. Janssen-Heininger, David E. Heppner, Loes van Lith, Andrew C. Little, Albert van der Vliet, Milena Hristova, Karamatullah Danyal, Caspar Schiffers, Christopher M. Dustin
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Lung cancers are frequently characterized by inappropriate activation of epidermal growth factor receptor (EGFR)-dependent signaling and epigenetic silencing of the NADPH oxidase (NOX) enzyme DUOX1, both potentially contributing to worse prognosis. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc066935b8d8270d72828fd67304f738
http://link.springer.com/article/10.1038/s41598-019-41395-8
http://link.springer.com/article/10.1038/s41598-019-41395-8