Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Miao-Miao Zhao"'
Hyperglycemia induced cathepsin L maturation linked to diabetic comorbidities and COVID-19 mortality
Autor:
Qiong He, Miao-Miao Zhao, Ming-Jia Li, Xiao-Ya Li, Jian-Min Jin, Ying-Mei Feng, Li Zhang, Wei Jin Huang, Fangyuan Yang, Jin-Kui Yang
Publikováno v:
eLife, Vol 13 (2024)
Diabetes, a prevalent chronic condition, significantly increases the risk of mortality from COVID-19, yet the underlying mechanisms remain elusive. Emerging evidence implicates Cathepsin L (CTSL) in diabetic complications, including nephropathy and r
Externí odkaz:
https://doaj.org/article/a9dc13b7423e4ba7b1dc7a0c847f4569
Autor:
Miao-Miao Zhao, Yun Zhu, Li Zhang, Gongxun Zhong, Linhua Tai, Shuo Liu, Guoliang Yin, Jing Lu, Qiong He, Ming-Jia Li, Ru-Xuan Zhao, Hao Wang, Weijin Huang, Changfa Fan, Lei Shuai, Zhiyuan Wen, Chong Wang, Xijun He, Qiuluan Chen, Banghui Liu, Xiaoli Xiong, Zhigao Bu, Youchun Wang, Fei Sun, Jin-Kui Yang
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-18 (2022)
Abstract The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important target for vaccine and drug development. However, the rapid emergence of variant strains with mutated S proteins has rendered many treatmen
Externí odkaz:
https://doaj.org/article/8787dfd1d6684523bb645431870ffa67
Autor:
Wei-Li Yang, Qi Li, Jing Sun, Sia Huat Tan, Yan-Hong Tang, Miao-Miao Zhao, Yu-Yang Li, Xi Cao, Jin-Cun Zhao, Jin-Kui Yang
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 2442-2454 (2022)
Cathepsin L (CTSL), a cysteine protease that can cleave and activate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, could be a promising therapeutic target for coronavirus disease 2019 (COVID-19). However, there is st
Externí odkaz:
https://doaj.org/article/43b61e7f3143492f9fcea1f4b0c8a5a3
Autor:
Miao-Miao Zhao, Jing Lu, Sen Li, Hao Wang, Xi Cao, Qi Li, Ting-Ting Shi, Kohichi Matsunaga, Chen Chen, Haixia Huang, Testuro Izumi, Jin-Kui Yang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Berberine is a compound with glucose-lowering effects in mice and humans. Here, the authors show that in mice berberine has beneficial glycemic effects by promoting insulin secretion, which requires the potassium channel KCNH6 in beta cells, and that
Externí odkaz:
https://doaj.org/article/ec84125247fe45d184dfac34b2787232
Autor:
Miao-Miao Zhao, Wei-Li Yang, Fang-Yuan Yang, Li Zhang, Wei-Jin Huang, Wei Hou, Chang-Fa Fan, Rong-Hua Jin, Ying-Mei Feng, You-Chun Wang, Jin-Kui Yang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-12 (2021)
Abstract To discover new drugs to combat COVID-19, an understanding of the molecular basis of SARS-CoV-2 infection is urgently needed. Here, for the first time, we report the crucial role of cathepsin L (CTSL) in patients with COVID-19. The circulati
Externí odkaz:
https://doaj.org/article/14361232a60c416c81e7cc39b1fc5f2c
Autor:
Miao-Miao Zhao, Jeremy Krebs, Xi Cao, Jing Cui, Dong-Ning Chen, Yu Li, Lin Hua, Jim Mann, Jin-Kui Yang
Publikováno v:
BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-8 (2019)
Abstract Background Helicobacter pylori infection is associated with several extragastric conditions including dyslipidemia and metabolic syndrome. This study aimed to investigate additional metabolic parameters associated with H. pylori infection in
Externí odkaz:
https://doaj.org/article/aac3cb479c234591ba18c9a8e91b6733
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
In arsenopyrite bioleaching, the interfacial reaction between mineral and cells is one of the most important factors. The energy of the interface is influenced by the mineralogical and microbiological characteristics. In this paper, the interfacial e
Externí odkaz:
https://doaj.org/article/d5177935875540d4a3722be61a84320d
Autor:
Miao-Miao Zhao, Jing Lu, Sen Li, Hao Wang, Xi Cao, Qi Li, Ting-Ting Shi, Kohichi Matsunaga, Chen Chen, Haixia Huang, Tetsuro Izumi, Jin-Kui Yang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/adae9d7881854d3bb950c3a484b1e470
Publikováno v:
Journal of Alloys and Compounds. 960:170685
Publikováno v:
Journal of Materials Chemistry C. 10:1334-1338
The β and γ phases of methylammonium chloride CH3NH3Cl and methylammonium bromide CH3NH3Br are identified to be ferroelectric via pyroelectric current and dielectric constant measurements.