Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Miao Clara K"'
Publikováno v:
Tetrahedron Letters. 34:2259-2262
Catalytic reduction of chiral 2-(2-pyridyl)-1,3-oxazolidines and 2-pyridyl imines derived from ( R )-phenylglycinol and ( R )-valinol afforded high diasteriomeric selectivity. Upon oxidative cleavage, the S - primary amine with high ee was obtained.
Autor:
Stephen Jacober, Philip W. Mui, Jerry W. Skiles, Sorcek Ronald J, Miao Clara K, Alan S. Rosenthal, Mcneil Daniel W
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:773-778
The synthesis of potential human leukocyte elastase (HLE) inhibitors containing conformationally restricted lactams as peptidomimetic replacements at P3-P2 and which contain a trifluoromethyl ketone of valine at P1 are described.
Publikováno v:
ChemInform. 23
Publikováno v:
ChemInform. 24
Catalytic reduction of chiral 2-(2-pyridyl)-1,3-oxazolidines and 2-pyridyl imines derived from ( R )-phenylglycinol and ( R )-valinol afforded high diasteriomeric selectivity. Upon oxidative cleavage, the S - primary amine with high ee was obtained.
Autor:
Sorcek Ronald J, Julian Adams, Lazer Edward S, J. M. Watrous, Yvan Guindon, H.‐C. Wong, Carol Ann Homon, Kollol Pal, Jürgen H. Nagel, Mark L. Behnke, A. Shah, Miao Clara K, A. G. Graham, A. Gilman, Denice M. Spero, Peter R. Farina
Publikováno v:
ChemInform. 25
Publikováno v:
Organic Preparations and Procedures International. 24:87-91
Autor:
Ian Potocki, Shirlynn Chen, Rosemarie Sellati, Patricia L. Reilly, Kei Kishimoto, Emeigh Jonathan Emilian, Gerald Nabozny, Robert Rothlein, Donghong A. Gao, Miao Clara K, Daniel R. Goldberg, Sorcek Ronald J, Daniel Kuzmich, Terence A. Kelly, Drané O'Brien, Deborah D. Jeanfavre, Charline Peng, and Stephen H. Norris, Kevin Chungeng Qian, Elizabeth Mainolfi, Wu Jiang-Ping, Joseph R. Woska, Jocelyn A. Gunn
Publikováno v:
Journal of medicinal chemistry. 47(22)
A novel class of lymphocyte function-associated antigen-1 (LFA-1) inhibitors is described. Discovered during the process to improve the physicochemical and metabolic properties of BIRT377 (1, Figure 1), a previously reported hydantoin-based LFA-1 inh
Autor:
Sorcek Ronald J, Simon J. Coutts, L. Churchill, Eva David, Mcneil Daniel W, Gunter Trummlitz, Hin-Chor Wong, Peter M. Grob, Ian Potocki, Hans Meier, Matt Aaron Tschantz, Wolfhard Engel, Lazer Edward S, Miao Clara K, A. G. Graham, Terence A. Kelly, Charles L. Cywin, Maryann Hoermann, Zhaoxing Meng, Roger J. Snow
Publikováno v:
Journal of medicinal chemistry. 40(6)
Meloxicam (5), an NSAID in the enol-carboxamide class, was developed on the basis of its antiinflammatory activity and relative safety in animal models. In subsequent screening in microsomal assays using human COX-1 and COX-2, we discovered that it p
Autor:
A. Gilman, Hin Chor Wong, Miao Clara K, Denice M. Spero, Kollol Pal, Mark L. Behnke, A. G. Graham, J. M. Watrous, Sorcek Ronald J, Lazer Edward S
Publikováno v:
Journal of medicinal chemistry. 37(7)
A series of benzoxazolamine and benzothiazolamine analogs that inhibit leukotriene (LT) biosynthesis are described. The initial lead, (S)-N-(benzothiazol-2- yl)phenylalanine ethyl ester (5a), was discovered in a screening program for inhibition of Ca
Autor:
Sorcek Ronald J, Miao Clara K, Philip W. Mui, Grace C. Chow, Genus J. Possanza, Jerry W. Skiles, Skoog M, Stephen Jacober, Weldon Sm, Keirns J
Publikováno v:
Journal of medicinal chemistry. 35(26)
A series of tripeptides which contain alpha,alpha-difluorostatone residues at P1-P1' and span the S3-S1' subsites have been shown to be potent inhibitors of human leukocyte elastase (HLE). The tripeptides described contain the nonproteinogenic achira