Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Miao Chia Lo"'
Publikováno v:
J Biol Chem
Triple-negative breast cancer (TNBC) is an aggressive cancer subtype for which effective therapies are unavailable. TNBC has a high frequency of tumor protein p53 (Tp53/p53)- and phosphatase and tensin homolog (PTEN) deficiencies, and combined p53- a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97cf8ea09760938e30a43a144145e25
https://doi.org/10.1074/jbc.ra119.010710
https://doi.org/10.1074/jbc.ra119.010710
Autor:
Russell C DeKelver, Benjamin Lewin, Kentson Lam, Yukiko Komeno, Ming Yan, Chandler Rundle, Miao-Chia Lo, Dong-Er Zhang
Publikováno v:
PLoS Genetics, Vol 9, Iss 10, p e1003765 (2013)
Fusion protein RUNX1-ETO (AML1-ETO, RUNX1-RUNX1T1) is expressed as the result of the 8q22;21q22 translocation [t(8;21)], which is one of the most common chromosomal abnormalities found in acute myeloid leukemia. RUNX1-ETO is thought to promote leukem
Externí odkaz:
https://doaj.org/article/54b91f9b29ce4e0aa589fdbf951ccef7
Autor:
Nicholas O. Stevers, Ramdane Harouaka, Chang-Ching Lin, Hui Jiang, Mari Gasparyan, Miao-Chia Lo, Max S. Wicha, Samantha L. Tinsley, Duxin Sun, Rebecca Moody
Publikováno v:
Cancer Letters. 480:51
Triple-negative breast cancer (TNBC) is the most difficult subtype of breast cancer to treat due to a paucity of effective targeted therapies. Many studies have reported that breast cancer stem cells (BCSCs) are enriched in TNBC and are responsible f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505ab11ecb646fe5019cb9fa2d98bd2d
https://doi.org/10.1016/j.canlet.2020.01.013
https://doi.org/10.1016/j.canlet.2020.01.013
Autor:
Ramdane Harouaka, Rebecca Moody, Nicholas O. Stevers, Miao-Chia Lo, Hui Jiang, Samantha L. Tinsley, Duxin Sun, Chang-Ching Lin, Max S. Wicha, Mari Gasparyan
Publikováno v:
Cancer letters. 438
Triple-negative breast cancer (TNBC) is the most difficult subtype of breast cancer to treat due to a paucity of effective targeted therapies. Many studies have reported that breast cancer stem cells (BCSCs) are enriched in TNBC and are responsible f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4af1f16c9212332fa05b260a63c81b92
https://pubmed.ncbi.nlm.nih.gov/32229161
https://pubmed.ncbi.nlm.nih.gov/32229161
Autor:
Nicholas O. Stevers, Samantha L. Tinsley, Chang-Ching Lin, Duxin Sun, Miao-Chia Lo, Rebecca Moody
Publikováno v:
Oncology Reports.
Targeting cancer stem cells (CSCs) is a key strategy to prevent cancers from developing drug resistance and metastasis. Mitochondria have been reported to be a vulnerability of CSCs by multiple studies. Here, we report that doxycycline, functioning a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53dac9b43c0ba6d9e224213ce60b7d6d
https://doi.org/10.3892/or.2018.6337
https://doi.org/10.3892/or.2018.6337
Autor:
Nicholas O. Stevers, Miao Chia Lo, Chang-Ching Lin, Jeanne A. Stuckey, Samantha L. Tinsley, Aleksas Matvekas, Duxin Sun, Jennifer L. Meagher, Rebecca Moody, Inkyung Jung
Publikováno v:
The Journal of biological chemistry. 293(6)
The transcription factor BCL11A has recently been reported to be a driving force in triple-negative breast cancer (TNBC), contributing to the maintenance of a chemoresistant breast cancer stem cell (BCSC) population. Although BCL11A was shown to supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b72a6479fc9414cc0c53cd9f2324cce
https://pubmed.ncbi.nlm.nih.gov/29263092
https://pubmed.ncbi.nlm.nih.gov/29263092
Autor:
Moshe Talpaz, Nicholas J. Donato, Shaomeng Wang, Jessica Mercer, Emilija Mitrikeska, Diane Giannola, Luke F. Peterson, Miao Chia Lo, Craig N. Johnson, Yihong Liu
Publikováno v:
Leukemialymphoma. 58(9)
Chronic myeloid leukemia (CML) is characterized by the chromosomal translocation 9;22, known as the Philadelphia chromosome (Ph), which produces the BCR-ABL fusion tyrosine kinase. Although well-managed by BCR-ABL tyrosine kinase inhibitors (TKIs), t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::590c2c4b3287f508fb784ad9db210faa
https://pubmed.ncbi.nlm.nih.gov/28084835
https://pubmed.ncbi.nlm.nih.gov/28084835
Autor:
Miao Chia Lo, Dan Ran, Dong-Er Zhang, Cody T. Mowery, Stephanie Weng, Samuel A Stoner, Kentson Lam, Amanda G Davis, Shinobu Matsuura
Publikováno v:
Leukemia, vol 31, iss 1
Leukemia
Leukemia
Granulocyte macrophage-colony-stimulating factor (GM-CSF) signaling regulates hematopoiesis and immune responses. CSF2RA, the gene encoding the α-subunit for GM-CSF, is significantly downregulated in t(8;21) (RUNX1-ETO or RE) leukemia patients, sugg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b100d6311b2a3c463663a21888fb53bc
https://escholarship.org/uc/item/3pz4h75w
https://escholarship.org/uc/item/3pz4h75w
Autor:
Kentson Lam, Yi-Jou Huang, Ming Yan, James R. Downing, Yukiko Komeno, Miao Chia Lo, Dong-Er Zhang, Shinobu Matsuura, Daniel G. Tenen
Publikováno v:
Blood, vol 123, iss 24
RUNX1 is an important transcription factor for hematopoiesis. There are multiple alternatively spliced isoforms of RUNX1. The best known isoforms are RUNX1a from use of exon 7A and RUNX1b and c from use of exon 7B. RUNX1a has unique functions due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54dfcf04cce0cdad74c200bc182b595
https://doi.org/10.1182/blood-2013-08-521252
https://doi.org/10.1182/blood-2013-08-521252
Autor:
Xiuli Cong, Justin H. Hickman, Russel C. DeKelver, Luke F. Peterson, Dong-Er Zhang, Miao Chia Lo, Denise Niewerth, Ming Yan
Publikováno v:
Leukemia
Oncogenic mutations in components of the JAK/STAT pathway, including those in cytokine receptors and JAKs, lead to increased activity of downstream signaling and are frequently found in leukemia and other hematological disorders. Thus, small-molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3248e56fcb717e5f5b4a4c4a0148edf6
https://doi.org/10.1038/leu.2013.197
https://doi.org/10.1038/leu.2013.197