An Optimized IoT-enabled Big Data Analytics Architecture for Edge-Cloud Computing.

Autor: Babar M; Department of Computer Science, Allama Iqbal Open University (AIOU), Islamabad, Pakistan., Ahmad Jan M; Department of Computer Science, Abdul Wali Khan University Mardan, Pakistan., He X; Global Big Data Technologies Center (GBDTC), School of Electrical and Data Engineering, University of Technology Sydney, Australia., Usman Tariq M; Abu Dhabi School of Management, Abu Dhabi, UAE., Mastorakis S; College of Information Science & Technology, University of Nebraska Omaha, USA., Alturki R; Department of Information Science, College of Computer and Information Systems, Umm Al-Qura University, Makkah, Saudi Arabia.

Publikováno v: IEEE internet of things journal [IEEE Internet Things J] 2023 Mar; Vol. 10 (5), pp. 3995-4005. Date of Electronic Publication: 2022 Mar 14.

Disease-specific variant pathogenicity prediction significantly improves variant interpretation in inherited cardiac conditions.

Autor: Zhang X; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield NHS, Foundation Trust London, London, United Kingdom., Walsh R; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield NHS, Foundation Trust London, London, United Kingdom., Whiffin N; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield NHS, Foundation Trust London, London, United Kingdom., Buchan R; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield NHS, Foundation Trust London, London, United Kingdom., Midwinter W; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield NHS, Foundation Trust London, London, United Kingdom., Wilk A; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield NHS, Foundation Trust London, London, United Kingdom., Govind R; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield NHS, Foundation Trust London, London, United Kingdom., Li N; Cardiovascular Research Centre, Royal Brompton and Harefield NHS, Foundation Trust London, London, United Kingdom.; MRC London Institute of Medical Sciences, Imperial College London, London, United Kingdom., Ahmad M; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield NHS, Foundation Trust London, London, United Kingdom., Mazzarotto F; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Cardiomyopathy Unit, Careggi University Hospital, Florence, Italy.; Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy., Roberts A; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield NHS, Foundation Trust London, London, United Kingdom., Theotokis PI; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield NHS, Foundation Trust London, London, United Kingdom., Mazaika E; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield NHS, Foundation Trust London, London, United Kingdom., Allouba M; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Aswan Heart Centre, Magdi Yacoub Heart Foundation, Aswan, Egypt., de Marvao A; MRC London Institute of Medical Sciences, Imperial College London, London, United Kingdom., Pua CJ; National Heart Centre, Singapore, Singapore., Day SM; Division of Cardiovascular Medicine and Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA., Ashley E; Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA, USA., Colan SD; Department of Cardiology, Boston Children's Hospital, Boston, MA, USA., Michels M; Department of Cardiology, Thoraxcenter, Erasmus MC Rotterdam, Rotterdam, Netherlands., Pereira AC; Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil., Jacoby D; Department of Internal Medicine, Yale University, New Haven, CT, USA., Ho CY; Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA., Olivotto I; Cardiomyopathy Unit, Careggi University Hospital, Florence, Italy., Gunnarsson GT; Faculty of Medicine, University of Iceland, Akureyri, Iceland., Jefferies JL; The Cardiovascular Institute, University of Tennessee, Memphis, TN, USA., Semsarian C; Centenary Institute, The University of Sydney, Sydney, Australia.; Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia., Ingles J; Centenary Institute, The University of Sydney, Sydney, Australia., O'Regan DP; MRC London Institute of Medical Sciences, Imperial College London, London, United Kingdom., Aguib Y; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Aswan Heart Centre, Magdi Yacoub Heart Foundation, Aswan, Egypt., Yacoub MH; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Aswan Heart Centre, Magdi Yacoub Heart Foundation, Aswan, Egypt., Cook SA; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield NHS, Foundation Trust London, London, United Kingdom.; National Heart Centre, Singapore, Singapore.; Duke-National University of Singapore, Singapore, Singapore., Barton PJR; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield NHS, Foundation Trust London, London, United Kingdom., Bottolo L; Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom. lb664@cam.ac.uk.; Alan Turing Institute, London, United Kingdom. lb664@cam.ac.uk.; MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom. lb664@cam.ac.uk., Ware JS; National Heart and Lung Institute, Imperial College London, London, United Kingdom. j.ware@imperial.ac.uk.; Cardiovascular Research Centre, Royal Brompton and Harefield NHS, Foundation Trust London, London, United Kingdom. j.ware@imperial.ac.uk.; MRC London Institute of Medical Sciences, Imperial College London, London, United Kingdom. j.ware@imperial.ac.uk.

Publikováno v: Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2021 Jan; Vol. 23 (1), pp. 69-79. Date of Electronic Publication: 2020 Oct 13.

Reevaluating the Genetic Contribution of Monogenic Dilated Cardiomyopathy.

Autor: Mazzarotto F; National Heart and Lung Institute (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., T.J.W.D., L.E.F., M.A., P.I.T., E.E., A.J.B., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.), Imperial College London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield National Health Service Foundation Trust, London, United Kingdom (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., L.E.F., M.A., P.I.T., E.E., A.J.B., A.A.P., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.).; Cardiomyopathy Unit, Careggi University Hospital, Florence, Italy (F.M., I.O.).; Department of Experimental and Clinical Medicine, University of Florence, Italy (F.M., I.O.)., Tayal U; National Heart and Lung Institute (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., T.J.W.D., L.E.F., M.A., P.I.T., E.E., A.J.B., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.), Imperial College London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield National Health Service Foundation Trust, London, United Kingdom (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., L.E.F., M.A., P.I.T., E.E., A.J.B., A.A.P., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.)., Buchan RJ; National Heart and Lung Institute (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., T.J.W.D., L.E.F., M.A., P.I.T., E.E., A.J.B., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.), Imperial College London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield National Health Service Foundation Trust, London, United Kingdom (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., L.E.F., M.A., P.I.T., E.E., A.J.B., A.A.P., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.)., Midwinter W; National Heart and Lung Institute (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., T.J.W.D., L.E.F., M.A., P.I.T., E.E., A.J.B., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.), Imperial College London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield National Health Service Foundation Trust, London, United Kingdom (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., L.E.F., M.A., P.I.T., E.E., A.J.B., A.A.P., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.)., Wilk A; National Heart and Lung Institute (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., T.J.W.D., L.E.F., M.A., P.I.T., E.E., A.J.B., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.), Imperial College London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield National Health Service Foundation Trust, London, United Kingdom (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., L.E.F., M.A., P.I.T., E.E., A.J.B., A.A.P., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.)., Whiffin N; National Heart and Lung Institute (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., T.J.W.D., L.E.F., M.A., P.I.T., E.E., A.J.B., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.), Imperial College London, United Kingdom.; Medical Research Council-London Institute of Medical Sciences (N.W. A.d.M., T.J.W.D., D.P.O., S.A.C., J.S.W.), Imperial College London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield National Health Service Foundation Trust, London, United Kingdom (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., L.E.F., M.A., P.I.T., E.E., A.J.B., A.A.P., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.)., Govind R; National Heart and Lung Institute (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., T.J.W.D., L.E.F., M.A., P.I.T., E.E., A.J.B., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.), Imperial College London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield National Health Service Foundation Trust, London, United Kingdom (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., L.E.F., M.A., P.I.T., E.E., A.J.B., A.A.P., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.)., Mazaika E; National Heart and Lung Institute (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., T.J.W.D., L.E.F., M.A., P.I.T., E.E., A.J.B., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.), Imperial College London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield National Health Service Foundation Trust, London, United Kingdom (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., L.E.F., M.A., P.I.T., E.E., A.J.B., A.A.P., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.)., de Marvao A; Medical Research Council-London Institute of Medical Sciences (N.W. A.d.M., T.J.W.D., D.P.O., S.A.C., J.S.W.), Imperial College London, United Kingdom., Dawes TJW; National Heart and Lung Institute (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., T.J.W.D., L.E.F., M.A., P.I.T., E.E., A.J.B., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.), Imperial College London, United Kingdom.; Medical Research Council-London Institute of Medical Sciences (N.W. A.d.M., T.J.W.D., D.P.O., S.A.C., J.S.W.), Imperial College London, United Kingdom., Felkin LE; National Heart and Lung Institute (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., T.J.W.D., L.E.F., M.A., P.I.T., E.E., A.J.B., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.), Imperial College London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield National Health Service Foundation Trust, London, United Kingdom (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., L.E.F., M.A., P.I.T., E.E., A.J.B., A.A.P., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.)., Ahmad M; National Heart and Lung Institute (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., T.J.W.D., L.E.F., M.A., P.I.T., E.E., A.J.B., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.), Imperial College London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield National Health Service Foundation Trust, London, United Kingdom (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., L.E.F., M.A., P.I.T., E.E., A.J.B., A.A.P., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.)., Theotokis PI; National Heart and Lung Institute (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., T.J.W.D., L.E.F., M.A., P.I.T., E.E., A.J.B., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.), Imperial College London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield National Health Service Foundation Trust, London, United Kingdom (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., L.E.F., M.A., P.I.T., E.E., A.J.B., A.A.P., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.)., Edwards E; National Heart and Lung Institute (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., T.J.W.D., L.E.F., M.A., P.I.T., E.E., A.J.B., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.), Imperial College London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield National Health Service Foundation Trust, London, United Kingdom (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., L.E.F., M.A., P.I.T., E.E., A.J.B., A.A.P., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.)., Ing AY; Laboratory for Molecular Medicine, Partners HealthCare Personalized Medicine, Cambridge, MA (A.Y.I.)., Thomson KL; Oxford Medical Genetics Laboratory, Oxford University Hospitals National Health Service Foundation Trust, The Churchill Hospital, United Kingdom (K.L.T.).; Radcliffe Department of Medicine, University of Oxford, United Kingdom (K.L.T., H.W.)., Chan LLH; National Heart Centre Singapore (L.L.H.C., D.S., S.A.C.)., Sim D; National Heart Centre Singapore (L.L.H.C., D.S., S.A.C.)., Baksi AJ; National Heart and Lung Institute (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., T.J.W.D., L.E.F., M.A., P.I.T., E.E., A.J.B., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.), Imperial College London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield National Health Service Foundation Trust, London, United Kingdom (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., L.E.F., M.A., P.I.T., E.E., A.J.B., A.A.P., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.)., Pantazis A; Cardiovascular Research Centre, Royal Brompton and Harefield National Health Service Foundation Trust, London, United Kingdom (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., L.E.F., M.A., P.I.T., E.E., A.J.B., A.A.P., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.)., Roberts AM; National Heart and Lung Institute (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., T.J.W.D., L.E.F., M.A., P.I.T., E.E., A.J.B., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.), Imperial College London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield National Health Service Foundation Trust, London, United Kingdom (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., L.E.F., M.A., P.I.T., E.E., A.J.B., A.A.P., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.)., Watkins H; Radcliffe Department of Medicine, University of Oxford, United Kingdom (K.L.T., H.W.)., Funke B; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston (B.F.)., O'Regan DP; Medical Research Council-London Institute of Medical Sciences (N.W. A.d.M., T.J.W.D., D.P.O., S.A.C., J.S.W.), Imperial College London, United Kingdom., Olivotto I; Cardiomyopathy Unit, Careggi University Hospital, Florence, Italy (F.M., I.O.).; Department of Experimental and Clinical Medicine, University of Florence, Italy (F.M., I.O.)., Barton PJR; National Heart and Lung Institute (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., T.J.W.D., L.E.F., M.A., P.I.T., E.E., A.J.B., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.), Imperial College London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield National Health Service Foundation Trust, London, United Kingdom (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., L.E.F., M.A., P.I.T., E.E., A.J.B., A.A.P., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.)., Prasad SK; National Heart and Lung Institute (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., T.J.W.D., L.E.F., M.A., P.I.T., E.E., A.J.B., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.), Imperial College London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield National Health Service Foundation Trust, London, United Kingdom (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., L.E.F., M.A., P.I.T., E.E., A.J.B., A.A.P., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.)., Cook SA; National Heart and Lung Institute (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., T.J.W.D., L.E.F., M.A., P.I.T., E.E., A.J.B., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.), Imperial College London, United Kingdom.; Medical Research Council-London Institute of Medical Sciences (N.W. A.d.M., T.J.W.D., D.P.O., S.A.C., J.S.W.), Imperial College London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield National Health Service Foundation Trust, London, United Kingdom (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., L.E.F., M.A., P.I.T., E.E., A.J.B., A.A.P., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.).; National Heart Centre Singapore (L.L.H.C., D.S., S.A.C.).; Duke-National University of Singapore Medical School (S.A.C.)., Ware JS; National Heart and Lung Institute (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., T.J.W.D., L.E.F., M.A., P.I.T., E.E., A.J.B., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.), Imperial College London, United Kingdom.; Medical Research Council-London Institute of Medical Sciences (N.W. A.d.M., T.J.W.D., D.P.O., S.A.C., J.S.W.), Imperial College London, United Kingdom.; Cardiovascular Research Centre, Royal Brompton and Harefield National Health Service Foundation Trust, London, United Kingdom (F.M., U.T., R.J.B., W.M., A.W., N.W., R.G., E.M., L.E.F., M.A., P.I.T., E.E., A.J.B., A.A.P., A.M.R., P.J.R.B., S.K.P., S.A.C., J.S.W.)., Walsh R; Department of Clinical and Experimental Cardiology, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam Universitair Medische Centra, University of Amsterdam, The Netherlands (R.W.).

Publikováno v: Circulation [Circulation] 2020 Feb 04; Vol. 141 (5), pp. 387-398. Date of Electronic Publication: 2020 Jan 27.

Genetic Variants Associated With Cancer Therapy-Induced Cardiomyopathy.

Autor: Garcia-Pavia P; Hospital Universitario Puerta de Hierro, Madrid, Spain (P.G.-P., M.A.R.-C., F.D., L.A.-P.).; Centro de Investigación Biomédica en Red Enfermedades in Cardiovascular Diseases (CIBERCV), Madrid, Spain (P.G.-P., M.A.R.-C., A.B.-G., J. Lupon, D.A.P.-F., J.M.G.-P., F.D., E.L.-P., L.A.-P.).; University Francisco de Vitoria, Pozuelo de Alarcón, Madrid, Spain (P.G.-P.)., Kim Y; Harvard Medical School, Boston, MA (Y.K., I.G.L., H.W., C.N.T., J.G., P.P., K.I., J.A.W., S.R.D., J.G.S., C.E.S.).; Massachusetts General Hospital, Boston (Y.K.)., Restrepo-Cordoba MA; Hospital Universitario Puerta de Hierro, Madrid, Spain (P.G.-P., M.A.R.-C., F.D., L.A.-P.).; Centro de Investigación Biomédica en Red Enfermedades in Cardiovascular Diseases (CIBERCV), Madrid, Spain (P.G.-P., M.A.R.-C., A.B.-G., J. Lupon, D.A.P.-F., J.M.G.-P., F.D., E.L.-P., L.A.-P.)., Lunde IG; Harvard Medical School, Boston, MA (Y.K., I.G.L., H.W., C.N.T., J.G., P.P., K.I., J.A.W., S.R.D., J.G.S., C.E.S.).; Oslo University Hospital and University of Oslo, Norway (I.G.L.)., Wakimoto H; Harvard Medical School, Boston, MA (Y.K., I.G.L., H.W., C.N.T., J.G., P.P., K.I., J.A.W., S.R.D., J.G.S., C.E.S.)., Smith AM; Perelman School of Medicine and University of Pennsylvania Health System, Philadelphia (A.M.S., K.G., Z.A., J. Li, A.T.O., B.F., R.A., B.K.)., Toepfer CN; Harvard Medical School, Boston, MA (Y.K., I.G.L., H.W., C.N.T., J.G., P.P., K.I., J.A.W., S.R.D., J.G.S., C.E.S.).; University of Oxford (C.N.T.)., Getz K; Perelman School of Medicine and University of Pennsylvania Health System, Philadelphia (A.M.S., K.G., Z.A., J. Li, A.T.O., B.F., R.A., B.K.)., Gorham J; Harvard Medical School, Boston, MA (Y.K., I.G.L., H.W., C.N.T., J.G., P.P., K.I., J.A.W., S.R.D., J.G.S., C.E.S.)., Patel P; Harvard Medical School, Boston, MA (Y.K., I.G.L., H.W., C.N.T., J.G., P.P., K.I., J.A.W., S.R.D., J.G.S., C.E.S.).; Brigham and Women's Hospital, Boston MA (P.P., C.E.S.)., Ito K; Harvard Medical School, Boston, MA (Y.K., I.G.L., H.W., C.N.T., J.G., P.P., K.I., J.A.W., S.R.D., J.G.S., C.E.S.)., Willcox JA; Harvard Medical School, Boston, MA (Y.K., I.G.L., H.W., C.N.T., J.G., P.P., K.I., J.A.W., S.R.D., J.G.S., C.E.S.)., Arany Z; Perelman School of Medicine and University of Pennsylvania Health System, Philadelphia (A.M.S., K.G., Z.A., J. Li, A.T.O., B.F., R.A., B.K.)., Li J; Perelman School of Medicine and University of Pennsylvania Health System, Philadelphia (A.M.S., K.G., Z.A., J. Li, A.T.O., B.F., R.A., B.K.)., Owens AT; Perelman School of Medicine and University of Pennsylvania Health System, Philadelphia (A.M.S., K.G., Z.A., J. Li, A.T.O., B.F., R.A., B.K.)., Govind R; National Heart & Lung Institute, Imperial College London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., E.L.-P., A.R.L., S.A.C., P.J.R.B., J.S.W.).; Royal Brompton & Harefield NHS Foundation Trust, London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., A.R.L., P.J.R.B., J.S.W.)., Nuñez B; Hospital Universitario Puerta de Hierro, Universidad Autónoma de Madrid, Spain (B.N., M.P.)., Mazaika E; National Heart & Lung Institute, Imperial College London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., E.L.-P., A.R.L., S.A.C., P.J.R.B., J.S.W.).; Royal Brompton & Harefield NHS Foundation Trust, London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., A.R.L., P.J.R.B., J.S.W.)., Bayes-Genis A; Centro de Investigación Biomédica en Red Enfermedades in Cardiovascular Diseases (CIBERCV), Madrid, Spain (P.G.-P., M.A.R.-C., A.B.-G., J. Lupon, D.A.P.-F., J.M.G.-P., F.D., E.L.-P., L.A.-P.).; Hospital Universitario Germans Trias i Pujol, Badalona, Spain (A.B.-G., J. Lupon)., Walsh R; National Heart & Lung Institute, Imperial College London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., E.L.-P., A.R.L., S.A.C., P.J.R.B., J.S.W.).; Royal Brompton & Harefield NHS Foundation Trust, London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., A.R.L., P.J.R.B., J.S.W.)., Finkelman B; Perelman School of Medicine and University of Pennsylvania Health System, Philadelphia (A.M.S., K.G., Z.A., J. Li, A.T.O., B.F., R.A., B.K.)., Lupon J; Centro de Investigación Biomédica en Red Enfermedades in Cardiovascular Diseases (CIBERCV), Madrid, Spain (P.G.-P., M.A.R.-C., A.B.-G., J. Lupon, D.A.P.-F., J.M.G.-P., F.D., E.L.-P., L.A.-P.).; Hospital Universitario Germans Trias i Pujol, Badalona, Spain (A.B.-G., J. Lupon)., Whiffin N; National Heart & Lung Institute, Imperial College London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., E.L.-P., A.R.L., S.A.C., P.J.R.B., J.S.W.).; Royal Brompton & Harefield NHS Foundation Trust, London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., A.R.L., P.J.R.B., J.S.W.).; MRC London Institute of Medical Sciences, Imperial College UK (N.W., D.P.O., S.A.C., J.S.W., C.E.S., A.d.M.)., Serrano I; Hospital Universitario de Tarragona Joan XXIII. IISPV, Rovira Virgili University, Spain (I.S., A.B.)., Midwinter W; National Heart & Lung Institute, Imperial College London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., E.L.-P., A.R.L., S.A.C., P.J.R.B., J.S.W.).; Royal Brompton & Harefield NHS Foundation Trust, London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., A.R.L., P.J.R.B., J.S.W.)., Wilk A; National Heart & Lung Institute, Imperial College London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., E.L.-P., A.R.L., S.A.C., P.J.R.B., J.S.W.).; Royal Brompton & Harefield NHS Foundation Trust, London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., A.R.L., P.J.R.B., J.S.W.)., Bardaji A; Hospital Universitario de Tarragona Joan XXIII. IISPV, Rovira Virgili University, Spain (I.S., A.B.)., Ingold N; National Heart & Lung Institute, Imperial College London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., E.L.-P., A.R.L., S.A.C., P.J.R.B., J.S.W.).; Royal Brompton & Harefield NHS Foundation Trust, London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., A.R.L., P.J.R.B., J.S.W.)., Buchan R; National Heart & Lung Institute, Imperial College London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., E.L.-P., A.R.L., S.A.C., P.J.R.B., J.S.W.).; Royal Brompton & Harefield NHS Foundation Trust, London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., A.R.L., P.J.R.B., J.S.W.)., Tayal U; National Heart & Lung Institute, Imperial College London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., E.L.-P., A.R.L., S.A.C., P.J.R.B., J.S.W.).; Royal Brompton & Harefield NHS Foundation Trust, London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., A.R.L., P.J.R.B., J.S.W.)., Pascual-Figal DA; Centro de Investigación Biomédica en Red Enfermedades in Cardiovascular Diseases (CIBERCV), Madrid, Spain (P.G.-P., M.A.R.-C., A.B.-G., J. Lupon, D.A.P.-F., J.M.G.-P., F.D., E.L.-P., L.A.-P.).; Hospital Universitario Virgen de la Arrixaca, University of Murcia. Spain (D.A.P.-F.)., de Marvao A; National Heart & Lung Institute, Imperial College London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., E.L.-P., A.R.L., S.A.C., P.J.R.B., J.S.W.).; Royal Brompton & Harefield NHS Foundation Trust, London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., A.R.L., P.J.R.B., J.S.W.).; MRC London Institute of Medical Sciences, Imperial College UK (N.W., D.P.O., S.A.C., J.S.W., C.E.S., A.d.M.)., Ahmad M; National Heart & Lung Institute, Imperial College London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., E.L.-P., A.R.L., S.A.C., P.J.R.B., J.S.W.).; Royal Brompton & Harefield NHS Foundation Trust, London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., A.R.L., P.J.R.B., J.S.W.)., Garcia-Pinilla JM; Centro de Investigación Biomédica en Red Enfermedades in Cardiovascular Diseases (CIBERCV), Madrid, Spain (P.G.-P., M.A.R.-C., A.B.-G., J. Lupon, D.A.P.-F., J.M.G.-P., F.D., E.L.-P., L.A.-P.).; Hospital Universitario Virgen de la Victoria, IBIMA, Malaga, Spain (J.M.G.-P.)., Pantazis A; National Heart & Lung Institute, Imperial College London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., E.L.-P., A.R.L., S.A.C., P.J.R.B., J.S.W.).; Royal Brompton & Harefield NHS Foundation Trust, London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., A.R.L., P.J.R.B., J.S.W.)., Dominguez F; Hospital Universitario Puerta de Hierro, Madrid, Spain (P.G.-P., M.A.R.-C., F.D., L.A.-P.).; Centro de Investigación Biomédica en Red Enfermedades in Cardiovascular Diseases (CIBERCV), Madrid, Spain (P.G.-P., M.A.R.-C., A.B.-G., J. Lupon, D.A.P.-F., J.M.G.-P., F.D., E.L.-P., L.A.-P.)., John Baksi A; National Heart & Lung Institute, Imperial College London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., E.L.-P., A.R.L., S.A.C., P.J.R.B., J.S.W.).; Royal Brompton & Harefield NHS Foundation Trust, London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., A.R.L., P.J.R.B., J.S.W.)., O'Regan DP; MRC London Institute of Medical Sciences, Imperial College UK (N.W., D.P.O., S.A.C., J.S.W., C.E.S., A.d.M.)., Rosen SD; National Heart & Lung Institute, Imperial College London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., E.L.-P., A.R.L., S.A.C., P.J.R.B., J.S.W.).; Royal Brompton & Harefield NHS Foundation Trust, London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., A.R.L., P.J.R.B., J.S.W.)., Prasad SK; National Heart & Lung Institute, Imperial College London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., E.L.-P., A.R.L., S.A.C., P.J.R.B., J.S.W.).; Royal Brompton & Harefield NHS Foundation Trust, London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., A.R.L., P.J.R.B., J.S.W.)., Lara-Pezzi E; Centro de Investigación Biomédica en Red Enfermedades in Cardiovascular Diseases (CIBERCV), Madrid, Spain (P.G.-P., M.A.R.-C., A.B.-G., J. Lupon, D.A.P.-F., J.M.G.-P., F.D., E.L.-P., L.A.-P.).; National Heart & Lung Institute, Imperial College London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., E.L.-P., A.R.L., S.A.C., P.J.R.B., J.S.W.).; Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain (E.L.-P.)., Provencio M; Hospital Universitario Puerta de Hierro, Universidad Autónoma de Madrid, Spain (B.N., M.P.)., Lyon AR; National Heart & Lung Institute, Imperial College London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., E.L.-P., A.R.L., S.A.C., P.J.R.B., J.S.W.).; Royal Brompton & Harefield NHS Foundation Trust, London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., A.R.L., P.J.R.B., J.S.W.)., Alonso-Pulpon L; Hospital Universitario Puerta de Hierro, Madrid, Spain (P.G.-P., M.A.R.-C., F.D., L.A.-P.).; Centro de Investigación Biomédica en Red Enfermedades in Cardiovascular Diseases (CIBERCV), Madrid, Spain (P.G.-P., M.A.R.-C., A.B.-G., J. Lupon, D.A.P.-F., J.M.G.-P., F.D., E.L.-P., L.A.-P.)., Cook SA; National Heart & Lung Institute, Imperial College London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., E.L.-P., A.R.L., S.A.C., P.J.R.B., J.S.W.).; MRC London Institute of Medical Sciences, Imperial College UK (N.W., D.P.O., S.A.C., J.S.W., C.E.S., A.d.M.).; National Heart Centre Singapore and Duke-National University of Singapore (S.A.C.)., DePalma SR; Harvard Medical School, Boston, MA (Y.K., I.G.L., H.W., C.N.T., J.G., P.P., K.I., J.A.W., S.R.D., J.G.S., C.E.S.).; Howard Hughes Medical Institute, Chevy Chase, MD (S.R.D., C.E.S.)., Barton PJR; National Heart & Lung Institute, Imperial College London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., E.L.-P., A.R.L., S.A.C., P.J.R.B., J.S.W.).; Royal Brompton & Harefield NHS Foundation Trust, London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., A.R.L., P.J.R.B., J.S.W.)., Aplenc R; Perelman School of Medicine and University of Pennsylvania Health System, Philadelphia (A.M.S., K.G., Z.A., J. Li, A.T.O., B.F., R.A., B.K.)., Seidman JG; Harvard Medical School, Boston, MA (Y.K., I.G.L., H.W., C.N.T., J.G., P.P., K.I., J.A.W., S.R.D., J.G.S., C.E.S.)., Ky B; Perelman School of Medicine and University of Pennsylvania Health System, Philadelphia (A.M.S., K.G., Z.A., J. Li, A.T.O., B.F., R.A., B.K.)., Ware JS; National Heart & Lung Institute, Imperial College London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., E.L.-P., A.R.L., S.A.C., P.J.R.B., J.S.W.).; Royal Brompton & Harefield NHS Foundation Trust, London, UK (R.G., E.M., R.W., N.W., W.M., A.W., N.I., R.B., U.T., A.d.M., M.A., A.P., A.J.B., S.D.R., S.K.P., A.R.L., P.J.R.B., J.S.W.).; MRC London Institute of Medical Sciences, Imperial College UK (N.W., D.P.O., S.A.C., J.S.W., C.E.S., A.d.M.)., Seidman CE; Harvard Medical School, Boston, MA (Y.K., I.G.L., H.W., C.N.T., J.G., P.P., K.I., J.A.W., S.R.D., J.G.S., C.E.S.).; MRC London Institute of Medical Sciences, Imperial College UK (N.W., D.P.O., S.A.C., J.S.W., C.E.S., A.d.M.).; Howard Hughes Medical Institute, Chevy Chase, MD (S.R.D., C.E.S.).; Brigham and Women's Hospital, Boston MA (P.P., C.E.S.).

Publikováno v: Circulation [Circulation] 2019 Jul 02; Vol. 140 (1), pp. 31-41. Date of Electronic Publication: 2019 Apr 16.

CardioClassifier: disease- and gene-specific computational decision support for clinical genome interpretation.

Autor: Whiffin N; National Heart & Lung Institute, Imperial College London, London, UK. n.whiffin@imperial.ac.uk.; Cardiovascular Research Centre at Royal Brompton and Harefield NHS Foundation Trust, London, UK. n.whiffin@imperial.ac.uk.; MRC London Institute of Medical Sciences, Imperial College London, London, UK. n.whiffin@imperial.ac.uk., Walsh R; National Heart & Lung Institute, Imperial College London, London, UK.; Cardiovascular Research Centre at Royal Brompton and Harefield NHS Foundation Trust, London, UK., Govind R; National Heart & Lung Institute, Imperial College London, London, UK.; Cardiovascular Research Centre at Royal Brompton and Harefield NHS Foundation Trust, London, UK., Edwards M; Clinical Genetics and Genomics Laboratory, Royal Brompton and Harefield NHS Foundation Trust, London, UK., Ahmad M; National Heart & Lung Institute, Imperial College London, London, UK.; Cardiovascular Research Centre at Royal Brompton and Harefield NHS Foundation Trust, London, UK., Zhang X; National Heart & Lung Institute, Imperial College London, London, UK.; Cardiovascular Research Centre at Royal Brompton and Harefield NHS Foundation Trust, London, UK., Tayal U; National Heart & Lung Institute, Imperial College London, London, UK.; Cardiovascular Research Centre at Royal Brompton and Harefield NHS Foundation Trust, London, UK., Buchan R; National Heart & Lung Institute, Imperial College London, London, UK.; Cardiovascular Research Centre at Royal Brompton and Harefield NHS Foundation Trust, London, UK., Midwinter W; National Heart & Lung Institute, Imperial College London, London, UK.; Cardiovascular Research Centre at Royal Brompton and Harefield NHS Foundation Trust, London, UK., Wilk AE; National Heart & Lung Institute, Imperial College London, London, UK.; Cardiovascular Research Centre at Royal Brompton and Harefield NHS Foundation Trust, London, UK., Najgebauer H; National Heart & Lung Institute, Imperial College London, London, UK.; Cardiovascular Research Centre at Royal Brompton and Harefield NHS Foundation Trust, London, UK., Francis C; National Heart & Lung Institute, Imperial College London, London, UK.; Cardiovascular Research Centre at Royal Brompton and Harefield NHS Foundation Trust, London, UK., Wilkinson S; Clinical Genetics and Genomics Laboratory, Royal Brompton and Harefield NHS Foundation Trust, London, UK., Monk T; Clinical Genetics and Genomics Laboratory, Royal Brompton and Harefield NHS Foundation Trust, London, UK., Brett L; Clinical Genetics and Genomics Laboratory, Royal Brompton and Harefield NHS Foundation Trust, London, UK., O'Regan DP; MRC London Institute of Medical Sciences, Imperial College London, London, UK., Prasad SK; National Heart & Lung Institute, Imperial College London, London, UK.; Cardiovascular Research Centre at Royal Brompton and Harefield NHS Foundation Trust, London, UK., Morris-Rosendahl DJ; National Heart & Lung Institute, Imperial College London, London, UK.; Clinical Genetics and Genomics Laboratory, Royal Brompton and Harefield NHS Foundation Trust, London, UK., Barton PJR; National Heart & Lung Institute, Imperial College London, London, UK.; Cardiovascular Research Centre at Royal Brompton and Harefield NHS Foundation Trust, London, UK., Edwards E; National Heart & Lung Institute, Imperial College London, London, UK.; Cardiovascular Research Centre at Royal Brompton and Harefield NHS Foundation Trust, London, UK., Ware JS; National Heart & Lung Institute, Imperial College London, London, UK.; Cardiovascular Research Centre at Royal Brompton and Harefield NHS Foundation Trust, London, UK.; MRC London Institute of Medical Sciences, Imperial College London, London, UK., Cook SA; National Heart & Lung Institute, Imperial College London, London, UK.; Cardiovascular Research Centre at Royal Brompton and Harefield NHS Foundation Trust, London, UK.; National Heart Centre Singapore, Singapore, Singapore.; Duke-National University of Singapore, Singapore, Singapore.

Publikováno v: Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2018 Oct; Vol. 20 (10), pp. 1246-1254. Date of Electronic Publication: 2018 Jan 25.