Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Mian Horvath"'
Autor:
Anthony R. Braun, Elly E. Liao, Mian Horvath, Prakriti Kalra, Karen Acosta, Malaney C. Young, Noah Nathan Kochen, Chih Hung Lo, Roland Brown, Michael D. Evans, William C. K. Pomerantz, Elizabeth Rhoades, Kelvin Luk, Razvan L. Cornea, David D. Thomas, Jonathan N. Sachs
Publikováno v:
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-17 (2021)
Abstract We have developed a high-throughput drug discovery platform, measuring fluorescence resonance energy transfer (FRET) with fluorescent alpha-synuclein (αSN) biosensors, to detect spontaneous pre-fibrillar oligomers in living cells. Our two
Externí odkaz:
https://doaj.org/article/ee6b8563f73c49f68804418a48d07270
Autor:
I. Deniz Derman, Miji Yeo, Diana Cadena Castaneda, Megan Callender, Mian Horvath, Zengshuo Mo, Ruoyun Xiong, Elizabeth Fleming, Phylip Chen, Mark E. Peeples, Karolina Palucka, Julia Oh, Ibrahim T. Ozbolat
Publikováno v:
bioRxiv
Human nasal epithelial cells (hNECs) are an essential cell source for the reconstruction of the respiratory pseudostratified columnar epithelium composed of multiple cell types in the context of infection studies and disease modeling. Hitherto, manua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329c0874664ec14bf104bec943c29e9d
https://doi.org/10.1101/2023.03.29.534723
https://doi.org/10.1101/2023.03.29.534723
Autor:
Aaron T. Balana, Anne-Laure Mahul-Mellier, Binh A Nguyen, Mian Horvath, Afraah Javed, Eldon R. Hard, Yllza Jasiqi, Preeti Singh, Shumaila Afrin, Rose Pedretti, Virender Singh, Virginia M.-Y. Lee, Kelvin C. Luk, Lorena Saelices, Hilal A. Lashuel, Matthew R. Pratt
Publikováno v:
bioRxiv
The process of amyloid fibril formation remains one of the primary targets for developing diagnostics and treatments for several neurodegenerative diseases (NDDs). Amyloid-forming proteins such α-Synuclein and Tau, which are implicated in the pathog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9a9ba932fcb45cc42feb6f11579b5d
https://doi.org/10.1101/2023.03.07.531573
https://doi.org/10.1101/2023.03.07.531573
Autor:
David D. Thomas, William C. K. Pomerantz, Prakriti Kalra, Michael D. Evans, Noah Nathan Kochen, Razvan L. Cornea, Mian Horvath, Jonathan N. Sachs, Chih Hung Lo, Roland Brown, Anthony R. Braun, Elly E. Liao, Kelvin C. Luk, Elizabeth Rhoades, Karen Acosta, Malaney C. Young
Publikováno v:
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-17 (2021)
NPJ Parkinson's Disease
NPJ Parkinson's Disease
We have developed a high-throughput drug discovery platform, measuring fluorescence resonance energy transfer (FRET) with fluorescent alpha-synuclein (αSN) biosensors, to detect spontaneous pre-fibrillar oligomers in living cells. Our two αSN FRET
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab1e793565ee58566feda2e9040c41c
https://doi.org/10.1038/s41531-021-00195-6
https://doi.org/10.1038/s41531-021-00195-6
Autor:
Mian Horvath, Bin Zhang, Angela Lo, Kelvin C. Luk, Tobias Raabe, Hannah J. Brown, Anna Stieber, Yuling Liang, Anna Caputo
Publikováno v:
eNeuro
Alpha-synuclein (aSyn) participates in synaptic vesicle trafficking and synaptic transmission, but its misfolding is also strongly implicated in Parkinson’s disease (PD) and other neurodegenerative disorders known as synucleinopathies where misfold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1fbdcb0e6f441d0fb58893c74d327cc
http://europepmc.org/articles/PMC7470929
http://europepmc.org/articles/PMC7470929
Autor:
Elly E. Liao, David D. Thomas, Chih Hung Lo, Mian Horvath, Michael D. Evans, Kelvin C. Luk, Jonathan N. Sachs, Roland Brown, Anthony R. Braun, Malaney C. Young
Preventing or reversing the pathological misfolding and self-association of alpha-synuclein (aSyn) can rescue a broad spectrum of pathological cellular insults that manifest in Parkinson’s Disease (PD), Dementia with Lewy bodies (DLB), and other al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab034dd024fb681ad79f7b98faaf228