Výsledky vyhledávání - "Mia Thorsélius"

Somatic hypermutation and VHgene usage in mantle cell lymphoma

Autor: Christer Sundström, Sarah H. Walsh, Inger Eriksson, Göran Roos, A. Johnson, Carin Backlin, Mia Thorsélius, Gunilla Enblad, Ulf Thunberg, Richard Rosenquist

Publikováno v: European Journal of Haematology. 68:217-224

B cell lymphomas and leukemias are heterogeneous tumors with different cellular origins. Analysis of immunoglobulin (Ig) genes enables insight into the B cell progenitor, as Ig somatic hypermutation correlates with antigen-related B cell transit thro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f86c73cbdb99e5a0048bde774be127ba
https://doi.org/10.1034/j.1600-0609.2002.01662.x

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A follicular dendritic cell line promotes somatic hypermutations in Ramos cells in vitro

Autor: Mia Thorsélius, Christer Sundström, Anders Rosén, Ola Söderberg, Jan Sällström, P. Canedo, Ulf Thunberg

Publikováno v: Scandinavian journal of immunology. 69(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c0a8b8370cd61d2eeb24562966bb58
https://pubmed.ncbi.nlm.nih.gov/19140879

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U-2973, a novel B-cell line established from a patient with a mature B-cell leukemia displaying concurrent t(14;18) and MYC translocation to a non-IG gene partner

Autor: Richard Rosenquist, Ingrid Thörn, Christer Sundström, Ann Nordgren, Karl-Johan Leuchowius, Mia Thorsélius, Hans Bostrom, Helene Hallböök, Ola Söderberg

Publikováno v: European journal of haematology. 81(3)

B-cell lymphomas/leukemias with simultaneous t(14;18)(q32;q21) and MYC rearrangements have recently been shown to constitute a separate diagnostic entity, presenting with a rapid clinical course and a very poor prognosis. We describe the establishmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c5d2df5626db681897b161e37ee676
https://pubmed.ncbi.nlm.nih.gov/18510704

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Comprehensive characterization of IGHV3-21-expressing B-cell chronic lymphocytic leukemia: an Italian multicenter study

Blood First Edition Paper, prepublished online December 5, 2006; DOI 10.1182/blood-2006-10-051110. IGHV3-21-using chronic lymphocytic leukemia (CLL) is a distinct entity with restricted immunoglobulin gene features and poor prognosis, more frequently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e79ffb1660b4dd3921414bcb3a156946
http://hdl.handle.net/2108/40695

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Strikingly homologous immunoglobulin gene rearrangements and poor outcome inV(H)3-21-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status

We recently reported that Swedish VH3-21-using chronic lymphocytic leukemia (CLL) patients showed restricted immunoglobulin gene features and poor prognosis despite VH mutation status. To investigate this further, we analyzed the VH and VL gene rearr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b4f407f65a7fea420ac6322c8c4f3f
https://hdl.handle.net/11380/613269

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Mantle cell lymphomas with clonal immunoglobulin V(H)3-21 gene rearrangements exhibit fewer genomic imbalances than mantle cell lymphomas utilizing other immunoglobulin V(H) genes

Autor: Mia Thorsélius, Ola Landgren, Sarah H. Walsh, Richard Rosenquist, Catharina Larsson, Svetlana Lagercrantz, Emma Flordal Thelander, Anna Laurell

Publikováno v: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 18(3)

A preferential use of one particular immunoglobulin variable heavy chain gene, V(H)3-21, has recently been reported in mantle cell lymphoma, where almost all of these V(H)3-21+ mantle cell lymphomas showed usage of the same light chain Vlambda gene (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec2180c697ea44c526b6b0504e3adc9
https://pubmed.ncbi.nlm.nih.gov/15257315

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Heterogeneous somatic hypermutation status confounds the cell of origin in hairy cell leukemia

Autor: Mia Thorsélius, Richard Rosenquist, Ulf Thunberg, Sarah H. Walsh, Hans Hagberg, Christer Sundström

Publikováno v: Leukemia research. 29(2)

Hairy cell leukemia (HCL) is thought to arise from a post-germinal center (GC) B-cell, however the exact normal counterpart remains unclear. We performed VH gene analysis of 32 HCL cases, revealing somatically mutated VH genes (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b1933b6261206d03e378b0d366ea1c
https://pubmed.ncbi.nlm.nih.gov/15607363

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Mutated VH genes and preferential VH3-21 use define new subsets of mantle cell lymphoma

Publikováno v: Blood. 101(10)

Mantle cell lymphoma (MCL) is believed to originate from a naive B cell. However, we recently demonstrated that a subset of MCL displayed mutated V-H genes. We also reported restricted use of certain V-H genes. To assess the prognostic impact of thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ef9fd63ea06d81929f5ba1ec9d12f9
https://pubmed.ncbi.nlm.nih.gov/12637326

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Somatic hypermutation and V(H) gene usage in mantle cell lymphoma

Autor: Mia, Thorsélius, Sarah, Walsh, Inger, Eriksson, Ulf, Thunberg, Anna, Johnson, Carin, Backlin, Gunilla, Enblad, Christer, Sundström, Göran, Roos, Richard, Rosenquist

Publikováno v: European journal of haematology. 68(4)

Mantle cell lymphoma (MCL) is considered to derive from naïve, pregerminal center (GC) CD5+ B-cells. However, the cell of origin has been questioned in recent studies that showed somatic hypermutations in the immunoglobulin (Ig) variable heavy chain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::91c32054ab73c7ce4b72b879a5c2f227
https://pubmed.ncbi.nlm.nih.gov/12071937

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