Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Mia Tazi"'
Autor:
Amr E. Ahmed, Madelyn M. Gerber, Hany Khalil, Duaa Dakhlallah, Ian C. Davis, Amal O. Amer, Mia Tazi, Kathrin Krause, Estelle Cormet-Boyaka, Sheng-Wei Chang, Larry S. Schlesinger, Benjamin T. Kopp, Amy E. Lovett-Racke, Clay B. Marsh, Kyle Caution
Publikováno v:
Autophagy. 12:2026-2037
Cystic fibrosis (CF) is a fatal, genetic disorder that critically affects the lungs and is directly caused by mutations in the CF transmembrane conductance regulator (CFTR) gene, resulting in defective CFTR function. Macroautophagy/autophagy is a hig
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology
As the eighth leading cause of annual mortality in the USA, influenza A viruses are a major public health concern. In 20% of patients, severe influenza progresses to acute lung injury (ALI). However, pathophysiological mechanisms underlying ALI devel
Autor:
Estelle Cormet-Boyaka, Kaitlin Hamilton, Kathrin Krause, Frank Robledo-Avila, Dmitry Tumin, Brett Klamer, Chandra L. Shrestha, Don Hayes, Stephen Kirkby, Amal O. Amer, Luanne Hall-Stoodley, Benjamin T. Kopp, Karen McCoy, Mia Tazi, Asmaa Badr, Kyle Caution, Xiaoli Zhang, Narasimham L. Parinandi, Santiago Partida-Sanchez, Duaa Dakhlallah
Publikováno v:
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 17(4)
INTRODUCTION: Cystic fibrosis (CF) is a multi-organ disorder characterized by chronic sino-pulmonary infections and inflammation. Many patients with CF suffer from repeated pulmonary exacerbations that are predictors of worsened long-term morbidity a
Autor:
Apurva Kanneganti, Mia Tazi, Kyle Caution, Kaivon Assani, Duaa Dakhlallah, Amr E. Ahmed, Amal O. Amer, Clay B. Marsh, Hany Khalil, Benjamin T. Kopp
Publikováno v:
Epigenetics. 11(5)
Autophagy is a biological process characterized by self-digestion and involves induction of autophagosome formation, leading to degradation of autophagic cargo. Aging is associated with the reduction of autophagy activity leading to neurodegenerative
Autor:
Howard A. Shuman, Mia Tazi, Evelyn Guirado, Anwari Akhter, Kyle Caution, Basant A. Abdulrahman, Larry S. Schlesinger, Andrew Doran, Arwa Abu Khweek, Amal O. Amer, Hoda Hassan, Neal Majumdar
Publikováno v:
European Journal of Immunology. 43:1333-1344
Legionella pneumophila (L. pneumophila) is an intracellular bacterium of human alveolar macrophages that causes Legionnaires' disease. In contrast to humans, most inbred mouse strains are restrictive to L. pneumophila replication. We demonstrate that
Autor:
Basant A. Abdulrahman, Kyle Caution, Ian C. Davis, Sankalp Malhotra, Mia Tazi, Hoda Hassan, Arwa Abu Khweek, Amal O. Amer, Miguel A. Valvano, Yucheng Zhang, Famke Aeffner, Anwari Akhter, Patrick D. Rowland
Publikováno v:
Abdulrahman, B A, Khweek, A A, Akhter, A, Caution, K, Tazi, M, Hassan, H, Zhang, Y, Rowland, P D, Malhotra, S, Aeffner, F, Davis, I C, Valvano, M A & Amer, A O 2013, ' Depletion of the ubiquitin-binding adaptor molecule SQSTM1/p62 from macrophages harboring cftr ΔF508 mutation improves the delivery of Burkholderia cenocepacia to the autophagic machinery ', Journal of Biological Chemistry, vol. 288, no. 3, pp. 2049-58 . https://doi.org/10.1074/jbc.M112.411728
Cystic fibrosis is the most common inherited lethal disease in Caucasians. It is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), of which the cftr ΔF508 mutation is the most common. ΔF508 macrophages are intri
Autor:
Mikhail A. Gavrilin, Mark D. Wewers, Hoda Hassan, Amal O. Amer, Basant A. Abdulrahman, Anwari Akhter, Oliver H. Voss, Mia Tazi, Larry S. Schlesinger, Kyle Caution, Abul K. Azad, Dalia H. A. Abdelaziz, Andrea I. Doseff, Arwa Abu Khweek
Publikováno v:
Immunity. 37(1):35-47
SummaryInflammasomes are multiprotein complexes that include members of the NLR (nucleotide-binding domain leucine-rich repeat containing) family and caspase-1. Once bacterial molecules are sensed within the macrophage, the inflammasome is assembled,
Autor:
Caroline M. Linke, Jason M. Stewart, Shireen A. Woodiga, Carolyn Marion, Amanda M. Burnaugh, Samantha J. King, Mia Tazi
Publikováno v:
Infection and Immunity. 80:1390-1398
The mechanisms by which Streptococcus pneumoniae obtains carbohydrates for growth during airway colonization remain to be elucidated. The low concentration of free carbohydrates in the normal human airway suggests that pneumococci must utilize comple
Autor:
Kyle Caution, Mikhail A. Gavrilin, Daniel Layman, Mia Tazi, Kathrin Krause, Amal O. Amer, Sheshadri Hoque, Apurva Kanneganti
Publikováno v:
Scientific Reports
Inflammasomes are multiprotein complexes that include members of the NOD-like receptor family and caspase-1. Caspase-1 is required for the fusion of the Legionella vacuole with lysosomes. Caspase-11, independently of the inflammasome, also promotes p
Autor:
Brian K. Rivera, Anna Bratasz, Karuppaiyah Selvendiran, M. Lakshmi Kuppusamy, Periannan Kuppusamy, Mia Tazi
Publikováno v:
International Journal of Cancer. 125:2198-2204
Signal transducer and activator of transcription 3 (STAT3) is activated in a variety of human cancers, including ovarian cancer. The molecular mechanism by which the STAT3 is activated in cancer cells is poorly understood. We observed that human ovar