Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Mia S, Geromella"'
Publikováno v:
Biomolecules, Vol 14, Iss 6, p 675 (2024)
Risk of cardiovascular disease mortality rises in women after menopause. While increased cardiovascular risk is largely attributed to postmenopausal declines in estrogens, the molecular changes in the heart that contribute to risk are poorly understo
Externí odkaz:
https://doaj.org/article/7a7e5f88eb664a5f8baf35f1a8a0b9f4
Autor:
Ryan W. Baranowski, Jessica L. Braun, Briana L. Hockey, Jenalyn L. Yumol, Mia S. Geromella, Colton J.F. Watson, Nigel Kurgan, Holt N. Messner, Kennedy C. Whitley, Adam J. MacNeil, Guillemette Gauquelin-Koch, Fabrice Bertile, William Gittings, Rene Vandenboom, Wendy E. Ward, Val A. Fajardo
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107047- (2023)
Summary: We examined the effects of ∼30 days of spaceflight on glycogen synthase kinase 3 (GSK3) content and inhibitory serine phosphorylation in murine muscle and bone samples from four separate missions (BION-M1, rodent research [RR]1, RR9, and R
Externí odkaz:
https://doaj.org/article/e4d4f424c12d421f9b505e655757ff9a
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 101987- (2023)
Summary: This protocol employs the indo-1 Ca2+ fluorophore to quantify Ca2+ uptake by the sarco(endo)plasmic reticulum Ca2+ ATPase pump in murine muscle homogenates and allows for real-time kinetic measurement of Ca2+ mobilization within the muscle h
Externí odkaz:
https://doaj.org/article/92f19cc60da347b08ebe330e852ef394
Autor:
Jessica L. Braun, Jisook Ryoo, Kyle Goodwin, Emily N. Copeland, Mia S. Geromella, Ryan W. Baranowski, Rebecca E. K. MacPherson, Val A. Fajardo
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/3d679120a1b246c2b5485b6acc67d0ff
Autor:
Riley E.G. Cleverdon, Jessica L. Braun, Mia S. Geromella, Kennedy C. Whitley, Daniel M. Marko, Sophie I. Hamstra, Brian D. Roy, Rebecca E.K. MacPherson, Val A. Fajardo
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104972- (2022)
Summary: The DBA/2J (D2) mdx mouse is a more severe model of Duchenne muscular dystrophy when compared to the traditional C57BL/10 (C57) mdx mouse. Here, we questioned whether sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) function would differ in
Externí odkaz:
https://doaj.org/article/50106664f0bf4e4cadafde9a1a5cf723
Autor:
Jessica L. Braun, Jisook Ryoo, Kyle Goodwin, Emily N. Copeland, Mia S. Geromella, Ryan W. Baranowski, Rebecca E. K. MacPherson, Val A. Fajardo
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
The sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) pump is responsible for the transport of Ca2+ from the cytosol into the sarcoplasmic reticulum at the expense of ATP, making it a regulator of both muscle relaxation and muscle-based energy expendi
Externí odkaz:
https://doaj.org/article/07c4ea9de3d74b558c00ba4a05fe44e9
Autor:
Jessica L. Braun, Holt N. Messner, Riley E. G. Cleverdon, Ryan W. Baranowski, Sophie I. Hamstra, Mia S. Geromella, Jeffrey A. Stuart, Val A. Fajardo
Publikováno v:
Physiological Reports, Vol 10, Iss 10, Pp n/a-n/a (2022)
Abstract The sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) restores intracellular Ca2+ ([Ca2+]i) to resting levels after muscle contraction, ultimately eliciting relaxation. SERCA pumps are highly susceptible to tyrosine (T)‐nitration, impairing
Externí odkaz:
https://doaj.org/article/031c24bbc2354d519fa7a191f0b7a432
Publikováno v:
FASEB BioAdvances, Vol 2, Iss 10, Pp 579-586 (2020)
Abstract Neuronatin (NNAT) was originally discovered in 1995 and labeled as a brain developmental gene due to its abundant expression in developing brains. Over the past 25 years, researchers have uncovered NNAT in other tissues; notably, the hypotha
Externí odkaz:
https://doaj.org/article/a4d84decad0746559eb60bab9f834107
Autor:
Bianca M. Marcella, Mia S. Geromella, Ahmad Mohammad, Jacob Sweezey-Munroe, Rebecca E. K. MacPherson, Val A. Fajardo
Publikováno v:
Muscles. 1:152-161
The sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) actively transports Ca2+ into the sarcoplasmic reticulum to facilitate cardiac muscle relaxation. Phospholamban (PLN) allosterically inhibits SERCA, and an imbalance of SERCA2a, dominant cardiac is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2837cedeca1f9a02390ea8168d7030ec
https://doi.org/10.3390/muscles1030016
https://doi.org/10.3390/muscles1030016
Publikováno v:
STAR protocols. 4(1)
This protocol employs the indo-1 Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957dc6b9ab6c4608e0b8502304cbaeef
https://pubmed.ncbi.nlm.nih.gov/36602905
https://pubmed.ncbi.nlm.nih.gov/36602905