Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Mia J. Smith"'
Autor:
Ryan M. Baxter, Christine S. Wang, Josselyn E. Garcia-Perez, Daniel S. Kong, Brianne M. Coleman, Valentyna Larchenko, Ronald P. Schuyler, Conner Jackson, Tusharkanti Ghosh, Pratyaydipta Rudra, Debdas Paul, Manfred Claassen, Rosemary Rochford, John C. Cambier, Debashis Ghosh, Jennifer C. Cooper, Mia J. Smith, Elena W. Y. Hsieh
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionMost childhood-onset SLE patients (cSLE) develop lupus nephritis (cLN), but only a small proportion achieve complete response to current therapies. The prognosis of children with LN and end-stage renal disease is particularly dire. Mortal
Externí odkaz:
https://doaj.org/article/a41397a204e54b1f9e4f77656d9bf4c0
Autor:
Catherine A. Nicholas, Mia J. Smith
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The COVID-19 pandemic coincided with several transformative advances in single-cell analysis. These new methods along with decades of research and trials with antibody therapeutics and RNA based technologies allowed for highly effective vaccines and
Externí odkaz:
https://doaj.org/article/cf5477aa73ee438789bcec08f3f852a3
Autor:
Moriah J. Castleman, Megan M. Stumpf, Nicholas R. Therrien, Mia J. Smith, Kelsey E. Lesteberg, Brent E. Palmer, James P. Maloney, William J. Janssen, Kara J. Mould, J. David Beckham, Roberta Pelanda, Raul M. Torres
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Double negative (DN) B cells (CD27-IgD-) comprise a heterogenous population of DN1, DN2, and the recently described DN3 and DN4 subsets. In autoimmune disease, DN2 cells are reported to be precursors to autoreactive antibody secreting cells and expan
Externí odkaz:
https://doaj.org/article/8100c6e2e03b46248febc8c0f54fdcb3
Autor:
Zachary C. Stensland, Brianne M. Coleman, Marynette Rihanek, Ryan M. Baxter, Peter A. Gottlieb, Elena W.Y. Hsieh, Virginia D. Sarapura, Kimber M. Simmons, John C. Cambier, Mia J. Smith
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103626- (2022)
Summary: Autoimmune thyroid disease (AITD) is caused by aberrant activation of the immune system allowing autoreactive B and T cells to target the thyroid gland leading to disease. Although AITD is more frequently diagnosed in adults, children are al
Externí odkaz:
https://doaj.org/article/30cb121fcd7e4390ab3193f5172a949c
Autor:
Zachary C. Stensland, Mia J. Smith
Publikováno v:
Magnetochemistry, Vol 7, Iss 7, p 92 (2021)
Over the years, various techniques have been utilized to study the function and phenotype of antigen-binding B cells in the primary repertoire following immunization, infection, and development of autoimmunity. Due to the low frequency of antigen-rea
Externí odkaz:
https://doaj.org/article/a42d1899ee6f48faba99e6c35eceeffe
Publikováno v:
Biomedicines, Vol 9, Iss 1, p 83 (2021)
B lymphocytes play critical roles in the development of autoimmunity, acting as autoantibody manufacturers, antigen-presenting cells, and producers of cytokines. Pan-B cell depletion has demonstrated efficacy in treatment of many autoimmune disorders
Externí odkaz:
https://doaj.org/article/5b6072cde55c49f4855d557cb46cd4e9
Autor:
Zachary C. Stensland, Christopher A. Magera, Hali Broncucia, Brittany D. Gomez, Nasha M. Rios-Guzman, Kristen L. Wells, Catherine A. Nicholas, Marynette Rihanek, Maya J. Hunter, Kevin P. Toole, Peter A. Gottlieb, Mia J. Smith
Publikováno v:
Journal of Experimental Medicine. 220
Recent evidence suggests a role for B cells in the pathogenesis of young-onset type 1 diabetes (T1D), wherein rapid progression occurs. However, little is known regarding the specificity, phenotype, and function of B cells in young-onset T1D. We perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3db6dce1c3d3ce1b7eefa7a639af6ff3
https://doi.org/10.1084/jem.20221604
https://doi.org/10.1084/jem.20221604
Autor:
Moriah J. Castleman, Megan M. Stumpf, Nicholas R. Therrien, Mia J. Smith, Kelsey E. Lesteberg, Brent E. Palmer, James P. Maloney, William J. Janssen, Kara J. Mould, J. David Beckham, Roberta Pelanda, Raul M. Torres
Publikováno v:
Journal of Experimental Medicine. 219
Severe SARS-CoV-2 infection is associated with strong inflammation and autoantibody production against diverse self-antigens, suggesting a system-wide defect in B cell tolerance. BND cells are a B cell subset in healthy individuals harboring autoreac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68475c2a6774f12718e7b390875b4ef6
https://doi.org/10.1084/jem.20212553
https://doi.org/10.1084/jem.20212553
Publikováno v:
Curr Opin Endocrinol Diabetes Obes
Purpose of review Although type 1 diabetes (T1D) is characterized by destruction of the pancreatic beta cells by self-reactive T cells, it has become increasingly evident that B cells also play a major role in disease development, likely functioning
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f043d0abdbe2a4e5a1e248dd892e8672
https://doi.org/10.1097/med.0000000000000547
https://doi.org/10.1097/med.0000000000000547
Autor:
Mia J. Smith, Zachary C. Stensland
Publikováno v:
Magnetochemistry (Basel, Switzerland)
Magnetochemistry, Vol 7, Iss 92, p 92 (2021)
Magnetochemistry, Vol 7, Iss 92, p 92 (2021)
Over the years, various techniques have been utilized to study the function and phenotype of antigen-binding B cells in the primary repertoire following immunization, infection, and development of autoimmunity. Due to the low frequency of antigen-rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7820969d23865381368f7056cb0bc2b
http://europepmc.org/articles/PMC8294334
http://europepmc.org/articles/PMC8294334