Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Mia Danielsen"'
Publikováno v:
Danielsen, M, Hempel, C, Andresen, T L & Urquhart, A J 2022, ' Biopharmaceutical nanoclusters: Towards the self-delivery of protein and peptide therapeutics ', Journal of controlled release, vol. 347, pp. 282-307 . https://doi.org/10.1016/j.jconrel.2022.04.050
Protein and peptide biopharmaceuticals have had a major impact on the treatment of a number of diseases. There is a growing interest in overcoming some of the challenges associated with biopharmaceuticals, such as rapid degradation in physiological f
Publikováno v:
International Journal of Biological Macromolecules. 235:123658
Autor:
Kira Røpke Jørgensen, David E. Gloriam, Jesper Mosolff Mathiesen, Mikael Frykman, Daniel Sejer Pedersen, Emil Märcher-Rørsted, Henrik Johansson, Tomasz M. Wróbel, Mia Danielsen, Hans Bräuner-Osborne, Birgit I. Gaiser
Publikováno v:
Journal of Medicinal Chemistry. 62:7806-7839
Herein, we report the development of bitopic ligands aimed at targeting the orthosteric binding site (OBS) and a metastable binding site (MBS) within the same receptor unit. Previous molecular dynamics studies on ligand binding to the β2-adrenergic
Autor:
Birgit I, Gaiser, Mia, Danielsen, Emil, Marcher-Rørsted, Kira, Røpke Jørgensen, Tomasz M, Wróbel, Mikael, Frykman, Henrik, Johansson, Hans, Bräuner-Osborne, David E, Gloriam, Jesper Mosolff, Mathiesen, Daniel, Sejer Pedersen
Publikováno v:
Journal of medicinal chemistry. 62(17)
Herein, we report the development of bitopic ligands aimed at targeting the orthosteric binding site (OBS) and a metastable binding site (MBS) within the same receptor unit. Previous molecular dynamics studies on ligand binding to the β
Autor:
Xavier Kubiak, Kresten Lindorff-Larsen, Nina Smidt Bengtson, Tjerk Jacco Sminia, Jesper Mosolff Mathiesen, Micha B. A. Kunze, Jacob Hartvig Løper, Søren G. F. Rasmussen, Mia Danielsen, Daniel Sejer Pedersen, Lotte-Emilie Boyhus, Phuong Thu Tran
Publikováno v:
Boyhus, L E, Danielsen, M, Bengtson, N S, Kunze, M B A, Kubiak, X, Sminia, T J, Løper, J H, Tran, P T, Lindorff-Larsen, K, Rasmussen, S G F, Mathiesen, J M & Pedersen, D S 2018, ' G s protein peptidomimetics as allosteric modulators of the β 2-adrenergic receptor ', RSC Advances, vol. 8, no. 4, pp. 2219-2228 . https://doi.org/10.1039/c7ra11713b
A series of Gs protein peptidomimetics were designed and synthesised based on the published X-ray crystal structure of the active state β2-Adrenergic receptor (β2AR) in complex with the Gs protein (PDB 3SN6). We hypothesised that such peptidomimeti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4826422f0dde00a279383acc49c6ec
https://curis.ku.dk/portal/da/publications/gs-protein-peptidomimetics-as-allosteric-modulators-of-the-2adrenergic-receptor(779a451a-aab3-4268-9abd-4cded6482c94).html
https://curis.ku.dk/portal/da/publications/gs-protein-peptidomimetics-as-allosteric-modulators-of-the-2adrenergic-receptor(779a451a-aab3-4268-9abd-4cded6482c94).html
Autor:
Cecilia Betti, Els Pardon, Daniel Sejer Pedersen, May C. Morris, Samuel L. C. Moors, Krisztina Fehér, Jesper Mosolff Mathiesen, Jan Steyaert, Mia Danielsen, Frank De Proft, Cecilia Fabris, Nick Devoogdt, Marion Peyressatre, Vicky Caveliers, Charlotte Martin, Steven Ballet, José C. Martins
Publikováno v:
Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2017, 23 (40), pp.9632-9640. ⟨10.1002/chem.201701321⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2017, 23 (40), pp.9632-9640. ⟨10.1002/chem.201701321⟩
International audience; G protein-coupled receptors (GPCRs) play an important role in many cellular responses; as such, their mechanism of action is of utmost interest. To gain insight into the active conformation of GPCRs, the X-ray crystal structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2593a1d011133dcfea65c9bd575cd9
https://doi.org/10.1002/chem.201701321
https://doi.org/10.1002/chem.201701321