Biopharmaceutical nanoclusters: Towards the self-delivery of protein and peptide therapeutics

Autor: Andrew Urquhart, Thomas Lars Andresen, Casper Hempel, Mia Danielsen

Publikováno v: Danielsen, M, Hempel, C, Andresen, T L & Urquhart, A J 2022, ' Biopharmaceutical nanoclusters: Towards the self-delivery of protein and peptide therapeutics ', Journal of controlled release, vol. 347, pp. 282-307 . https://doi.org/10.1016/j.jconrel.2022.04.050

Protein and peptide biopharmaceuticals have had a major impact on the treatment of a number of diseases. There is a growing interest in overcoming some of the challenges associated with biopharmaceuticals, such as rapid degradation in physiological f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f0138058cd4a71d1b249ce36221b28
https://doi.org/10.1016/j.jconrel.2022.04.050

Probing the Existence of a Metastable Binding Site at the β2-Adrenergic Receptor with Homobivalent Bitopic Ligands

Autor: Kira Røpke Jørgensen, David E. Gloriam, Jesper Mosolff Mathiesen, Mikael Frykman, Daniel Sejer Pedersen, Emil Märcher-Rørsted, Henrik Johansson, Tomasz M. Wróbel, Mia Danielsen, Hans Bräuner-Osborne, Birgit I. Gaiser

Publikováno v: Journal of Medicinal Chemistry. 62:7806-7839

Herein, we report the development of bitopic ligands aimed at targeting the orthosteric binding site (OBS) and a metastable binding site (MBS) within the same receptor unit. Previous molecular dynamics studies on ligand binding to the β2-adrenergic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f266c9b44be06ae8c41471ac2e4cba3
https://doi.org/10.1021/acs.jmedchem.9b00595

Gs protein peptidomimetics as allosteric modulators of the β2-adrenergic receptor

Autor: Xavier Kubiak, Kresten Lindorff-Larsen, Nina Smidt Bengtson, Tjerk Jacco Sminia, Jesper Mosolff Mathiesen, Micha B. A. Kunze, Jacob Hartvig Løper, Søren G. F. Rasmussen, Mia Danielsen, Daniel Sejer Pedersen, Lotte-Emilie Boyhus, Phuong Thu Tran

Publikováno v: Boyhus, L E, Danielsen, M, Bengtson, N S, Kunze, M B A, Kubiak, X, Sminia, T J, Løper, J H, Tran, P T, Lindorff-Larsen, K, Rasmussen, S G F, Mathiesen, J M & Pedersen, D S 2018, ' G s protein peptidomimetics as allosteric modulators of the β 2-adrenergic receptor ', RSC Advances, vol. 8, no. 4, pp. 2219-2228 . https://doi.org/10.1039/c7ra11713b

A series of Gs protein peptidomimetics were designed and synthesised based on the published X-ray crystal structure of the active state β2-Adrenergic receptor (β2AR) in complex with the Gs protein (PDB 3SN6). We hypothesised that such peptidomimeti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4826422f0dde00a279383acc49c6ec
https://curis.ku.dk/portal/da/publications/gs-protein-peptidomimetics-as-allosteric-modulators-of-the-2adrenergic-receptor(779a451a-aab3-4268-9abd-4cded6482c94).html

Rational Design of Nanobody80 Loop Peptidomimetics: Towards Biased β

Autor: Charlotte, Martin, Samuel L C, Moors, Mia, Danielsen, Cecilia, Betti, Cecilia, Fabris, Daniel, Sejer Pedersen, Els, Pardon, Marion, Peyressatre, Krisztina, Fehér, José C, Martins, Jesper, Mosolff Mathiesen, May C, Morris, Nick, Devoogdt, Vicky, Caveliers, Frank, De Proft, Jan, Steyaert, Steven, Ballet

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 23(40)

G protein-coupled receptors (GPCRs) play an important role in many cellular responses; as such, their mechanism of action is of utmost interest. To gain insight into the active conformation of GPCRs, the X-ray crystal structures of nanobody (Nb)-stab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::66cac9dbb9f482963ad89fb9aea8221c
https://pubmed.ncbi.nlm.nih.gov/28449310