Co-expression of TIMP-1 and its cell surface binding partner CD63 in glioblastomas

Autor: Charlotte Aaberg-Jessen, Mia D. Sørensen, Ana L. S. A. Matos, José M. Moreira, Nils Brünner, Arnon Knudsen, Bjarne W. Kristensen

Publikováno v: BMC Cancer, Vol 18, Iss 1, Pp 1-16 (2018)

Abstract Background We have previously identified tissue inhibitor of metalloproteinases-1 (TIMP-1) as a prognostic marker in glioblastomas. TIMP-1 has been associated with chemotherapy resistance, and CD63, a known TIMP-1-binding protein, has been s

Externí odkaz: https://doaj.org/article/cd2be74ab6b34f708de1601d26d6e461

The Epigenetic Regulator Jumonji Domain-Containing Protein 6 (JMJD6) Is Highly Expressed but Not Prognostic in IDH-Wildtype Glioblastoma Patients

Autor: Ann Mari Rosager, Rikke H Dahlrot, Mia D Sørensen, Julie A Bangsø, Steinbjørn Hansen, Bjarne W Kristensen

Publikováno v: Rosager, A M, Dahlrot, R H, Sørensen, M D, Bangsø, J A, Hansen, S & Kristensen, B W 2022, ' The Epigenetic Regulator Jumonji Domain-Containing Protein 6 (JMJD6) Is Highly Expressed but Not Prognostic in IDH-Wildtype Glioblastoma Patients ', Journal of Neuropathology and Experimental Neurology, vol. 81, no. 1, pp. 54-60 . https://doi.org/10.1093/jnen/nlab124

Patients with IDH-wildtype glioblastoma (GBM) generally have a poor prognosis. However, there is an increasing need of novel robust biomarkers in the daily clinico-pathological setting to identify and support treatment in patients who become long-tim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ec4869eb1457ef66374812102cd0ff
https://doi.org/10.1093/jnen/nlab124

Expression and prognostic impact of matrix metalloproteinase-2 (MMP-2) in astrocytomas.

Autor: Rahimsan K Ramachandran, Mia D Sørensen, Charlotte Aaberg-Jessen, Simon K Hermansen, Bjarne W Kristensen

Publikováno v: PLoS ONE, Vol 12, Iss 2, p e0172234 (2017)

Astrocytomas are the most frequent primary brain tumors in adults, and despite aggressive treatment patients often experience recurrence. Survival decreases with increasing tumor grade, and especially patients with grade IV glioblastoma have poor pro

Externí odkaz: https://doaj.org/article/eb85423c0e4e42b98b0d6c95ef0a37fd

Tumour-associated CD204+ microglia/macrophages accumulate in perivascular and perinecrotic niches and correlate with an interleukin-6-enriched inflammatory profile in glioblastoma

Autor: Bjarne Winther Kristensen, Mia D. Sørensen

Publikováno v: Sørensen, M D & Kristensen, B W 2022, ' Tumour-associated CD204+ microglia/macrophages accumulate in perivascular and perinecrotic niches and correlate with an interleukin-6-enriched inflammatory profile in glioblastoma ', Neuropathology and Applied Neurobiology, vol. 48, no. 2, e12772 . https://doi.org/10.1111/nan.12772
Sorensen, M D & Kristensen, B W 2022, ' Tumour-associated CD204 + microglia/macrophages accumulate in perivascular and perinecrotic niches and correlate with an interleukin-6-enriched inflammatory profile in glioblastoma ', Neuropathology and Applied Neurobiology, vol. 48, no. 2, 12772 . https://doi.org/10.1111/nan.12772

AIMS: Glioblastomas are heterogeneous tumours with a rich tumour microenvironment particularly comprised of tumour-associated microglia/macrophages (TAMs), but also containing a population of dedifferentiated/stem-like glioblastoma cells. Both cell p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58aa3b8282a03ed9b7ba7df5653f9315
https://findresearcher.sdu.dk:8443/ws/files/199075349/Neuropathology_Appl_Neurobio_2021_S_rensen_Tumour_associated_CD204_microglia_macrophages_accumulate_in_perivascular.pdf

The presence of TIM‐3 positive cells in WHO grade III and IV astrocytic gliomas correlates with isocitrate dehydrogenase mutation status

Autor: Bjarne Winther Kristensen, Mia D. Sørensen, Ole Haagen Nielsen, Guido Reifenberger

Publikováno v: D Sørensen, M, Nielsen, O, Reifenberger, G & W Kristensen, B 2021, ' The presence of TIM-3 positive cells in WHO grade III and IV astrocytic gliomas correlates with isocitrate dehydrogenase mutation status ', Brain Pathology, vol. 31, no. 3, e12921 . https://doi.org/10.1111/bpa.12921
D. Sørensen, M, Nielsen, O, Reifenberger, G & W. Kristensen, B 2021, ' The presence of TIM-3 positive cells in WHO grade III and IV astrocytic gliomas correlates with isocitrate dehydrogenase mutation status ', Brain Pathology, vol. 31, no. 3, e12921 . https://doi.org/10.1111/bpa.12921
Brain Pathology

Diffuse gliomas are aggressive brain tumors that respond poorly to immunotherapy including immune checkpoint inhibition. This resistance may arise from an immunocompromised microenvironment and deficient immune recognition of tumor cells because of l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222673e8cf79bf2bd0a671e0fe1115e5
https://doi.org/10.1111/bpa.12921