Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Mia Abels"'
Autor:
Andreas Lindqvist, Mia Abels, Liliya Shcherbina, Mtakai Ngara, Dmytro Kryvokhyzha, Sabrina Chriett, Matteo Riva, Abul Fajul, Mohammad Barghouth, Cheng Luan, Lena Eliasson, Olav Larsen, Mette M. Rosenkilde, Enming Zhang, Erik Renström, Nils Wierup
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108416- (2023)
Summary: Cocaine and amphetamine-regulated transcript (CART) is expressed in pancreatic islet cells and neuronal elements. We have previously established insulinotropic actions of CART in human and rodent islets. The receptor for CART in the pancreat
Externí odkaz:
https://doaj.org/article/5b28e5d6ce9a49798e8b5a806ad188f3
Autor:
Lisa M. Nicholas, Bérengère Valtat, Anya Medina, Lotta Andersson, Mia Abels, Inês G. Mollet, Deepak Jain, Lena Eliasson, Nils Wierup, Malin Fex, Hindrik Mulder
Publikováno v:
Molecular Metabolism, Vol 6, Iss 7, Pp 651-663 (2017)
Objective: Insulin release from pancreatic β-cells is controlled by plasma glucose levels via mitochondrial fuel metabolism. Therefore, insulin secretion is critically dependent on mitochondrial DNA (mtDNA) and the genes it encodes. Mitochondrial tr
Externí odkaz:
https://doaj.org/article/7c8420984bd24f1c94b700a9d5958e76
Autor:
Mia Abels, Matteo Riva, Liliya Shcherbina, Ann-Helen Thorén Fischer, Elin Banke, Eva Degerman, Andreas Lindqvist, Nils Wierup
Publikováno v:
Peptides. 151
Impaired beta cell function and beta cell death are key features of type 2 diabetes (T2D). Cocaine- and amphetamine-regulated transcript (CART) is necessary for normal islet function in mice. CART increases glucose-stimulated insulin secretion in viv
Publikováno v:
Peptides. 149
Cocaine- and amphetamine-regulated transcript (CART) is mostly known for its appetite regulating effects in the central nervous system. However, CART is also highly expressed in the peripheral nervous system as well as in certain endocrine cells. Our
Autor:
Ola Hansson, Emilia Ottosson-Laakso, Anders Lindqvist, S. Chriett, Nils Wierup, Lena Eliasson, J.A. Martínez López, Gad Hatem, Leif Groop, Rashmi B. Prasad, Mia Abels, Anna Edlund, Olof Asplund, Liliya Shcherbina
Publikováno v:
Molecular and cellular endocrinology. 521
Here we show that scratch family transcriptional repressor 1 (SCRT1), a zinc finger transcriptional regulator, is a novel regulator of beta cell function. SCRT1 was found to be expressed in beta cells in rodent and human islets. In human islets, expr
Autor:
Inês G. Mollet, Malin Fex, Lisa M. Nicholas, Bérengère Valtat, Nils Wierup, Lena Eliasson, Mia Abels, Deepak Jain, Hindrik Mulder, Lotta Andersson, Anya Medina
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 6, Iss 7, Pp 651-663 (2017)
Molecular Metabolism, Vol 6, Iss 7, Pp 651-663 (2017)
Objective Insulin release from pancreatic β-cells is controlled by plasma glucose levels via mitochondrial fuel metabolism. Therefore, insulin secretion is critically dependent on mitochondrial DNA (mtDNA) and the genes it encodes. Mitochondrial tra
Autor:
Inês G. Mollet, Bob J. Scholte, Nils Wierup, Michael Huhn, Lena Eliasson, Emma Svedin, Anna Wendt, Anna Edlund, Enming Zhang, Jonathan L.S. Esguerra, Erik Renström, Malin Flodström-Tullberg, Mia Abels, Mohammad Barghouth
Publikováno v:
Journal of Endocrinology, 241(1), 45-57. Bioscientifica Ltd
Cystic fibrosis-related diabetes (CFRD) is a common complication for patients with cystic fibrosis (CF), a disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). The cause of CFRD is unclear, but a commonly obs
Autor:
Michael G. Miskelly, Liliya Shcherbina, Nils Wierup, Ann Helen Thorén Fischer, Andreas Lindqvist, Mia Abels
Publikováno v:
Peptides. 136:170445
Roux-en-Y gastric bypass (RYGB) is the most effective treatment for morbid obesity and results in rapid remission of type 2 diabetes (T2D), before significant weight loss occurs. The underlying mechanisms for T2D remission are not fully understood. T
Autor:
Jens Hjerling-Leffler, Rikard G. Fred, Mia Abels, Anders Lindqvist, Rashmi B. Prasad, Liliya Shcherbina, Leif Groop, Jan Hedenbro, J A Martínez-Lopéz, M G Miskelly, Nils Wierup, B J Nergard
Publikováno v:
Molecular and Cellular Endocrinology. 511:110835
It is not known how ghrelin affects insulin secretion in human islets from patients with type 2 diabetes (T2D) or whether islet ghrelin expression or circulating ghrelin levels are altered in T2D. Here we sought out to identify the effect of ghrelin
Autor:
Anna Edlund, Yuedan Zhou, Claes B. Wollheim, Nils Wierup, Liliya Shcherbina, Emilia Ottosson-Laakso, Lena Eliasson, Ola Hansson, Mia Abels, Jonathan L.S. Esguerra
Publikováno v:
Molecular and Cellular Endocrinology, Vol. 447 (2017) pp. 52-60
Impaired beta-cell function is key to the development of type 2 diabetes. Cocaine- and amphetamine-regulated transcript (CART) is an islet peptide with insulinotropic and glucagonostatic properties. Here we studied the role of endogenous CART in beta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44993e1ccfc224da3c6e68dbb5d48f14
https://archive-ouverte.unige.ch/unige:94430
https://archive-ouverte.unige.ch/unige:94430