Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Mia Aaboe Jørgensen"'
2
Akademický článek
TGFβ-derived immune modulatory vaccine: targeting the immunosuppressive and fibrotic tumor microenvironment in a murine model of pancreatic cancer
Autor: Marco Donia, Mads Hald Andersen, Lars Grøntved, Daniel Hargbøl Madsen, Inés Lecoq, Evelina Martinenaite, Mia Aaboe Jørgensen, Stine Emilie Weis-Banke, Morten Orebo Holmström, Maria Perez-Penco, Aimilia Schina, Mie Linder Hübbe, Majken Siersbæk, Niels Ødum, Lucia Lara de la Torre, Simone Kloch Bendtsen
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 12 (2022)
Background Pancreatic ductal adenocarcinoma (PDAC) is associated with very poor survival, making it the third and fourth leading cause of all cancer-related deaths in the USA and European Union, respectively. The tumor microenvironment (TME) in PDAC
Externí odkaz: https://doaj.org/article/9b7ffc36e9674c6099fd906a29e40d4b
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3
Akademický článek
Peptide vaccination activating Galectin-3-specific T cells offers a novel means to target Galectin-3-expressing cells in the tumor microenvironment
Autor: Simone Kloch Bendtsen, Maria Perez-Penco, Mie Linder Hübbe, Evelina Martinenaite, Morten Orebo Holmström, Stine Emilie Weis-Banke, Nicolai Grønne Dahlager Jørgensen, Mia Aaboe Jørgensen, Shamaila Munir Ahmad, Kasper Mølgaard Jensen, Christina Friese, Mia Thorup Lundsager, Astrid Zedlitz Johansen, Marco Carretta, Niels Ødum, Özcan Met, Inge Marie Svane, Daniel Hargbøl Madsen, Mads Hald Andersen
Publikováno v: OncoImmunology, Vol 11, Iss 1 (2022)
Galectin-3 (Gal3) can be expressed by many cells in the tumor microenvironment (TME), including cancer cells, cancer-associated fibroblasts, tumor-associated macrophages, and regulatory T cells (Tregs). In addition to immunosuppression, Gal3 expressi
Externí odkaz: https://doaj.org/article/4a88182fd3824e069baeb2dcda39bf1d
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4
Akademický článek
Arginase-2-specific cytotoxic T cells specifically recognize functional regulatory T cells
Autor: Marco Donia, Mads Hald Andersen, Özcan Met, Lars Grøntved, Daniel Hargbøl Madsen, Inge Marie Svane, Mia Aaboe Jørgensen, Stine Emilie Weis-Banke, Morten Orebo Holmström, Thomas Landkildehus Lisle, Maria Perez-Penco, Aimilia Schina, Mie Linder Hübbe, Majken Siersbæk, Niels Ødum
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 10 (2022)
Background High expression of the metabolic enzyme arginase-2 (ARG2) by cancer cells, regulatory immune cells, or cells of the tumor stroma can reduce the availability of arginine (L-Arg) in the tumor microenvironment (TME). Depletion of L-Arg has de
Externí odkaz: https://doaj.org/article/fff8e87a81a74470aaa2d8cac2b4d443
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6
Akademický článek
The metabolic enzyme arginase-2 is a potential target for novel immune modulatory vaccines
Autor: Stine Emilie Weis-Banke, Mie Linder Hübbe, Morten Orebo Holmström, Mia Aaboe Jørgensen, Simone Kloch Bendtsen, Evelina Martinenaite, Marco Carretta, Inge Marie Svane, Niels Ødum, Ayako Wakatsuki Pedersen, Özcan Met, Daniel Hargbøl Madsen, Mads Hald Andersen
Publikováno v: OncoImmunology, Vol 9, Iss 1 (2020)
One way that tumors evade immune destruction is through tumor and stromal cell expression of arginine-degrading enzyme arginase-2 (ARG2). Here we describe the existence of pro-inflammatory effector T-cells that recognize ARG2 and can directly target
Externí odkaz: https://doaj.org/article/ea0ac61138cc45ada890530c9c9af0c1
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7
Akademický článek
Spontaneous T-cell responses against Arginase-1 in the chronic myeloproliferative neoplasms relative to disease stage and type of driver mutation
Autor: Mia Aaboe Jørgensen, Morten Orebo Holmström, Evelina Martinenaite, Caroline Hasselbalch Riley, Hans Carl Hasselbalch, Mads Hald Andersen
Publikováno v: OncoImmunology, Vol 7, Iss 9 (2018)
Compelling evidence supports the existence of a profound immune dysregulation in patients with chronic myeloproliferative neoplasms (MPN). Increased Arginase-1 expression has been described in MPN patients and in solid cancers. This increase contribu
Externí odkaz: https://doaj.org/article/a456711a1bdb48699fe7ea665010c115
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8
Akademický článek
The inhibitory checkpoint, PD-L2, is a target for effector T cells: Novel possibilities for immune therapy
Autor: Shamaila Munir Ahmad, Evelina Martinenaite, Morten Holmström, Mia Aaboe Jørgensen, Özcan Met, Claudia Nastasi, Uffe Klausen, Marco Donia, Lars Møller Pedersen, Lars Munksgaard, Niels Ødum, Anders Woetmann, Inge Marie Svane, Mads Hald Andersen
Publikováno v: OncoImmunology, Vol 7, Iss 2 (2018)
Cell surface molecules of the B7/CD28 family play an important role in T-cell activation and tolerance. The relevance of the PD-1/PD-L1 pathway in cancer has been extensively studied whereas PD-L2 has received less attention. However, recently the ex
Externí odkaz: https://doaj.org/article/44486a2d00ca4729b4fb08b58c877161
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